Article ; Online: 2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease.
Chemico-biological interactions
2020 Volume 335, Page(s) 109348
Abstract: The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment. The SARS-CoV-2 main protease ( ... ...
| Abstract | The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment. The SARS-CoV-2 main protease (M |
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| MeSH term(s) | Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacokinetics ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacokinetics ; Caco-2 Cells ; Catalytic Domain ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/metabolism ; Cysteine Proteinase Inhibitors/pharmacokinetics ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Pyridones/chemistry ; Pyridones/metabolism ; Pyridones/pharmacokinetics ; SARS-CoV-2/enzymology | |||||
| Chemical Substances | Antiviral Agents ; Biological Products ; Cysteine Proteinase Inhibitors ; Pyridones ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) | |||||
| Language | English | |||||
| Publishing date | 2020-12-02 | |||||
| Publishing country | Ireland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 218799-1 | |||||
| ISSN | 1872-7786 ; 0009-2797 | |||||
| ISSN (online) | 1872-7786 | |||||
| ISSN | 0009-2797 | |||||
| DOI | 10.1016/j.cbi.2020.109348 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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