Artikel ; Online: Influence of fludarabine on the pharmacokinetics of oral busulfan during pretransplant conditioning for hematopoietic stem cell transplantation.
Journal of clinical pharmacology
2013 Band 53, Heft 11, Seite(n) 1205–1211
Abstract: This study evaluated the influence of fludarabine on the pharmacokinetics of busulfan administered orally to patients receiving a conditioning regimen for hematopoietic allogeneic stem cell transplantation (HSCT). Twenty-six patients treated with oral ... ...
Abstract | This study evaluated the influence of fludarabine on the pharmacokinetics of busulfan administered orally to patients receiving a conditioning regimen for hematopoietic allogeneic stem cell transplantation (HSCT). Twenty-six patients treated with oral busulfan (1 mg/kg/6 h for 4 days) were divided into two groups according to the concomitant administration of fludarabine (n = 11; 30 mg/m(2) for 5 days) or subsequent administration of cyclophosphamide (n = 15; 60 mg/kg for 2 days). Serial blood samples were collected on Day 4 of busulfan administration. Plasma busulfan concentrations were determined by HPLC-UV and the pharmacokinetic parameters were calculated using the WinNonlin program. Patients concomitantly treated with fludarabine showed reduced apparent clearance of busulfan (110.5 mL/h/kg vs. 157.4 mL/h/kg) and higher AUC0-6 (area under the plasma concentrations vs. time curve) than patients subsequently treated with cyclophosphamide (7.9 µg h/mL vs. 5.7 µg h/mL). No association was observed between busulfan AUC0-6 and clinical evolution of the patients. Although plasma busulfan concentrations were higher in patients receiving concomitant fludarabine, myelosuppression-related toxicity was less frequent than in patients treated with busulfan and cyclophosphamide. The results suggest that patients treated with fludarabine should receive 30% lower busulfan doses during conditioning protocols for HSCT. |
---|---|
Mesh-Begriff(e) | Adolescent ; Adult ; Alkylating Agents/administration & dosage ; Alkylating Agents/blood ; Alkylating Agents/pharmacokinetics ; Busulfan/administration & dosage ; Busulfan/blood ; Busulfan/pharmacokinetics ; Cyclophosphamide/administration & dosage ; Drug Interactions ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Middle Aged ; Myeloablative Agonists/administration & dosage ; Transplantation Conditioning ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives ; Young Adult |
Chemische Substanzen | Alkylating Agents ; Myeloablative Agonists ; Cyclophosphamide (8N3DW7272P) ; Vidarabine (FA2DM6879K) ; Busulfan (G1LN9045DK) ; fludarabine (P2K93U8740) |
Sprache | Englisch |
Erscheinungsdatum | 2013-11 |
Erscheinungsland | England |
Dokumenttyp | Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 188980-1 |
ISSN | 1552-4604 ; 0091-2700 ; 0021-9754 |
ISSN (online) | 1552-4604 |
ISSN | 0091-2700 ; 0021-9754 |
DOI | 10.1002/jcph.130 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Uf I Zs.176: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.