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Article ; Online: Oncogene-induced senescence in meningiomas-an immunohistochemical study.

Mijajlović, Vladimir / Miler, Marko / Ilić, Rosanda / Rašić, Dejan / Dunđerović, Duško / Raičević, Savo / Soldatović, Ivan / De Luka, Silvio / Manojlović-Gačić, Emilija

Journal of neuro-oncology

2023 Volume 166, Issue 1, Page(s) 143–153

Abstract: Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to ... ...

Abstract	Purpose: Meningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization classification of the tumours of the Central Nervous System. Factors contributing to the progression to the higher grades (grades 2 and 3) have not been elucidated yet. Senescence has been proposed as a potential mechanism constraining the malignant transformation of tumours. Senescence-associated beta-galactosidase (SA-β-GAL) and inhibitors of cyclin-dependent kinases p16 and p21 have been suggested as senescence markers. Methods: We analysed 318 meningiomas of total 343 (178 grade 1, 133 grade 2 and 7 grade 3). Tissue microarrays were constructed and stained immunohistochemically, using antibodies for SA-β-GAL, p16 and p21. Results: The positive correlation of the tumour grade with the expression of p16 (p = 0.016) and SA-β-GAL (p = 0.002) was observed. The expression of p16 and SA-β-GAL was significantly higher in meningiomas grade 2 compared to meningiomas grade 1 (p = 0.006 and p = 0.004, respectively). SA-β-GAL positivity positively correlated with p16 and p21 in the whole cohort. In grade 2 meningiomas, a positive correlation was only between SA-β-GAL and p16. Correlations of senescence markers in meningiomas grade 2 were not present. Conclusion: Our findings suggest the senescence activation in meningiomas grade 2 as a potential mechanism for the restraining of tumour growth and give hope for applying of promising senolytic therapy.
MeSH term(s)	Humans ; Meningioma ; Cellular Senescence/physiology ; Oncogenes ; beta-Galactosidase/metabolism ; Central Nervous System/chemistry ; Central Nervous System/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Meningeal Neoplasms
Chemical Substances	beta-Galactosidase (EC 3.2.1.23) ; Cyclin-Dependent Kinase Inhibitor p16
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-023-04532-y
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Article ; Online: Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature.

Ivaniš, S / Jovanović, M / Dunđerović, D / Zorić, G / Odalović, B / Slijepčević, N / Taušanović, K / Rovčanin, B / Buzejić, M / Vučen, D / Stepanović, B / Ilić, J / Parezanović, M / Marinković, M / Stojanović, M / Tošković, A / Mojsić, I / Živaljević, V

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 280, Issue 12, Page(s) 5637–5647

Abstract: Introduction: Non functional parathyroid carcinoma (PC) is one of the rarest malignant neoplasms. Due to the lack of symptoms and laboratory findings, it is mostly diagnosed in late AQ2 stages, when local invasion and dissemination are already present. ... ...

Abstract	Introduction: Non functional parathyroid carcinoma (PC) is one of the rarest malignant neoplasms. Due to the lack of symptoms and laboratory findings, it is mostly diagnosed in late AQ2 stages, when local invasion and dissemination are already present. However, our case is an exception, because it was detected in early stage, with no local invasion present. We present a case of the smallest non-functional PC yet reported and review of the literature. Case presentation: A 47-year-old woman was admitted to outpatient Clinic where fine-needle aspiration biopsy (FNAB) of bilateral thyroid nodules (slide 1) and central neck mass (slide 2), which was suspected to be an enlarged lymphatic nodule or parathyroid gland was performed. Results came back as Bethesda I-colloid (slide 1), and Bethesda IV (slide 2), stating that it is hard to distinguish thyroid gland oxyphil lesions from parathyroid cells. Total thyroidectomy was performed as well as excision of the left central neck mass, without any involvement of surrounding structures. Pathological examination revealed bilateral thyroid follicular nodular disease, papillary microcarcinoma, and parathyroid carcinoma with vascular and capsular invasion, measuring 10 × 8 × 7 mm. The immunohistochemical profile included positive PTH, Chromogranin A, and negative TTF1. Conclusion: Non-functional PC is usually diagnosed in advanced stages, already involving adjacent structures; however, this case presents a rare example. It is important not to exclude PC as a differential diagnosis in the absence of elevated Ca and PTH serum levels. Follow-up will be difficult, since there are no prognostic parameters to rely on.
MeSH term(s)	Female ; Humans ; Middle Aged ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/surgery ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Thyroid Nodule/pathology ; Thyroidectomy/methods
Language	English
Publishing date	2023-07-26
Publishing country	Germany
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-08137-z
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Article: Dual Role of

Jelača, Sanja / Jovanovic, Ivan / Bovan, Dijana / Jovanovic, Marina Z / Jurisevic, Milena M / Dunđerović, Duško / Dajic-Stevanovic, Zora / Arsenijevic, Nebojsa / Mijatović, Sanja / Maksimović-Ivanić, Danijela

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: Ethnomedicinal records have long mentioned the historical usage ... ...

Abstract	Ethnomedicinal records have long mentioned the historical usage of
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17030286
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Article ; Online: Novel triphenyltin(IV) compounds with carboxylato

Kasalović, Marijana P / Jelača, Sanja / Milanović, Žiko / Maksimović-Ivanić, Danijela / Mijatović, Sanja / Lađarević, Jelena / Božić, Bojan / Marković, Zoran / Dunđerović, Duško / Rüffer, Tobias / Kretschmer, Robert / Kaluđerović, Goran N / Pantelić, Nebojša Đ

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 19, Page(s) 8298–8314

Abstract: Three newly synthesized triphenyltin(IV) compounds, Ph3SnL1 (L1- = 3-(4-methyl-2-oxoquinolin-1( ... ...

Abstract	Three newly synthesized triphenyltin(IV) compounds, Ph3SnL1 (L1- = 3-(4-methyl-2-oxoquinolin-1(2
MeSH term(s)	Organotin Compounds/chemistry ; Organotin Compounds/pharmacology ; Organotin Compounds/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Humans ; Animals ; Mice ; Drug Screening Assays, Antitumor ; Quinolones/chemistry ; Quinolones/pharmacology ; Quinolones/chemical synthesis ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Density Functional Theory ; Molecular Structure ; Structure-Activity Relationship ; Cell Survival/drug effects
Language	English
Publishing date	2024-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d4dt00182f
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Article ; Online: FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo.

Mihajlović, Ekatarina / Biancalana, Lorenzo / Jelača, Sanja / Chiaverini, Lorenzo / Dojčinović, Biljana / Dunđerović, Duško / Zacchini, Stefano / Mijatović, Sanja / Maksimović-Ivanić, Danijela / Marchetti, Fabio

Journal of medicinal chemistry

2024 Volume 67, Issue 9, Page(s) 7553–7568

Abstract: ... ...

Abstract	FETPY
MeSH term(s)	Animals ; Humans ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Coordination Complexes/chemical synthesis ; Coordination Complexes/therapeutic use ; Drug Screening Assays, Antitumor ; Iron/chemistry ; Iron/metabolism ; Lipid Peroxidation/drug effects ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology ; Mice, Inbred C57BL
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00377
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Article ; Online: Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies.

Drača, Dijana / Edeler, David / Saoud, Mohamad / Dojčinović, Biljana / Dunđerović, Duško / Đmura, Goran / Maksimović-Ivanić, Danijela / Mijatović, Sanja / Kaluđerović, Goran N

Journal of inorganic biochemistry

2021 Volume 217, Page(s) 111383

Abstract: CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP ...

Abstract	CP (cisplatin) and mesoporous silica SBA-15 (Santa Barbara amorphous 15) loaded with CP (→SBA-15\|CP) were tested in vitro and in vivo against low metastatic mouse melanoma B16F1 cell line. SBA-15 only, as drug carrier, is found to be not active, while CP and SBA-15\|CP revealed high cytotoxicity in lower μM range. The activity of SBA-15\|CP was found similar to the activity of CP alone. Both CP and SBA-15\|CP induced inhibition of cell proliferation (carboxyfluorescein succinimidyl ester - CFSE assay) along with G2/M arrest (4',6-diamidino-2-phenylindole - DAPI assay). Apoptosis (Annexin V/ propidium iodide - PI assay), through caspase activation (apostat assay) and nitric oxide (NO) production (diacetate(4-amino-5-methylamino-2',7'-difluorofluorescein-diacetat) - DAF FM assay), was identified as main mode of cell death. However, slight elevated autophagy (acridine orange - AO assay) was detected in treated B16F1 cells. CP and SBA-15\|CP did not affect production of ROS (reactive oxygen species) in B16F1 cells. Both SBA-15\|CP and CP induced in B16F1 G2 arrest and subsequent senescence. SBA-15\|CP, but not CP, blocked the growth of melanoma in C57BL/6 mice. Moreover, hepato- and nephrotoxicity in SBA-15\|CP treated animals were diminished in comparison to CP confirming multiply improved antitumor potential of immobilized CP. Outstandingly, SBA-15 boosted in vivo activity and diminished side effects of CP.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Carriers/chemistry ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology ; Mice, Inbred C57BL ; Nanoparticles/chemistry ; Nitric Oxide/metabolism ; Porosity ; Silicon Dioxide/chemistry ; Mice
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; SBA-15 ; Nitric Oxide (31C4KY9ESH) ; Silicon Dioxide (7631-86-9) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111383
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Article: Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy: A case report and review of literature.

Vujosevic, Snezana / Krnjevic, Djordjije / Bogojevic, Milan / Vuckovic, Ljiljana / Filipovic, Aleksandar / Dunđerović, Duško / Sopta, Jelena

World journal of clinical cases

2019 Volume 7, Issue 4, Page(s) 473–481

Abstract: Background: Leiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature (limited to English).: Case ... ...

Abstract	Background: Leiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature (limited to English). Case summary: Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed, followed by radiotherapy. Since metastases were also discovered in the lungs, sternum, and femur, chemotherapy was administered as well. Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus. Conclusion: Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.
Language	English
Publishing date	2019-01-26
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v7.i4.473
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Article: Mesoporous Silica Nanoparticles Enhance the Anticancer Efficacy of Platinum(IV)-Phenolate Conjugates in Breast Cancer Cell Lines.

Predarska, Ivana / Saoud, Mohamad / Drača, Dijana / Morgan, Ibrahim / Komazec, Teodora / Eichhorn, Thomas / Mihajlović, Ekatarina / Dunđerović, Duško / Mijatović, Sanja / Maksimović-Ivanić, Danijela / Hey-Hawkins, Evamarie / Kaluđerović, Goran N

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 21

Abstract: The main reasons for the limited clinical efficacy of the platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well as the possibility to introduce biologically active ligands in their ...

Abstract	The main reasons for the limited clinical efficacy of the platinum(II)-based agent cisplatin include drug resistance and significant side effects. Due to their better stability, as well as the possibility to introduce biologically active ligands in their axial positions constructing multifunctional prodrugs, creating platinum(IV) complexes is a tempting strategy for addressing these limitations. Another strategy for developing chemotherapeutics with lower toxicity relies on the ability of nanoparticles to accumulate in greater quantities in tumor tissues through passive targeting. To combine the two approaches, three platinum(IV) conjugates based on a cisplatin scaffold containing in the axial positions derivatives of caffeic and ferulic acid were prepared and loaded into SBA-15 to produce the corresponding mesoporous silica nanoparticles (MSNs). The free platinum(IV) conjugates demonstrated higher or comparable activity with respect to cisplatin against different human breast cancer cell lines, while upon immobilization, superior antiproliferative activity with markedly increased cytotoxicity (more than 1000-fold lower IC
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12213767
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Article ; Online: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.

Filipović, Jelena / Bosić, Martina / Ćirović, Sanja / Životić, Maja / Dunđerović, Duško / Đorđević, Dejan / Živković-Perišić, Snežana / Lipkovski, Aleksandar / Marković-Lipkovski, Jasmina

Diagnostic pathology

2019 Volume 14, Issue 1, Page(s) 120

Abstract: Background: Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal cell tumors (RCT) is unknown.: ... ...

Abstract	Background: Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal cell tumors (RCT) is unknown. Methods: We evaluated PRMT1 immunohistochemical (IHC) expression on tissue microarray (TMA) of 208 specimens of RCT, including clear cell renal cell carcinomas (ccRCC), papillary RCC type I and II (pRCC I and II), chromophobe RCC (chRCC), renal oncocytomas (RO), collecting duct carcinomas - Bellini (CDC) and multilocular cystic renal cell neoplasms of low malignant potential (MLCRN-LMP). Moreover, a subset of ccRCC, pRCC, chRCC, RO were also studied using conventional sections. PRMT1 expression in tumor tissue was compared to the IHC expression of EMT-related transcription factors (ZEB1, RUNX1, and TWIST1) and cell surface markers (ß-catenin, N- and E-cadherin). Additionally, qRT-PCR expression of PRMT1 in ccRCC, pRCC, and chRCC was evaluated and the results were compared to the mRNA PRMT1 transcript profiling data in The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) cohort. Results: PRMT1 immunoreactivity was observed in the majority of ccRCC, RO, all MLCRN-LMP, but in a minority of chRCC (p = 0.044), and it was associated with low grade and low stage ccRCC (p = 0.014; p = 0.044, respectively). ZEB1 immunoreactivity was noted in all RO, in minority of chRCC and neither of MLCRN-LMP (p < 0.001). The majority of PRMT1-negative ccRCC was negative to ZEB1 and showed cytoplasmic expression of TWIST1 (p = 0.028; p < 0.001, respectively). PRMT1 positive ccRCC mostly expressed RUNX1 (p = 0.019). PRMT1 and ZEB1 expression were associated with better cancer-specific survival in patients with ccRCC (p = 0.029; p = 0.009, respectively). In multivariate analysis, ZEB1 expression was an independent prognostic factor for cancer-specific survival (hazard ratio [HR], 0.367; p = 0.026). Significant IHC heterogeneity was observed in PRMT1, ZEB1 and TWIST1 expression (p < 0.001). Homogenous loss of PRMT1 was associated with high grade and high stage ccRCC, while the homogenous loss of PRMT1 and ZEB1 was more frequent in patients who died of ccRCC (p = 0.017; p = 0.040; p = 0.044; p = 0.009, respectively). Relative mRNA-PRMT1 expression in both cohorts was down-regulated in tumor tissue compared to non-tumor parenchyma (p = 0.009). Unlike in our samples, mRNA-PRMT1 expression in the TCGA cohort was not correlated to ccRCC tumor stage or grade. PRMT1, ZEB1, and TWIST1 expression were not associated with EMT related aberrant ß-catenin expression, a gain of N-cadherin or loss of E-cadherin expression. Only RUNX1 was associated with a gain of N-cadherin (p = 0.003). Conclusions: IHC expression of PRMT1 may be characteristic for low grade and low stage ccRCC, while the homogenous loss of PRMT1 may be significant for high grade and high stage ccRCC. Both, PRMT1 and/or ZEB1 expression, could be associated with better survival of the patients with ccRCC.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Diagnosis, Differential ; Epithelial-Mesenchymal Transition/genetics ; Female ; Humans ; Kidney/pathology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Prognosis ; Protein-Arginine N-Methyltransferases/genetics ; Repressor Proteins/genetics
Chemical Substances	Biomarkers, Tumor ; Repressor Proteins ; PRMT1 protein, human (EC 2.1.1.319) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319)
Language	English
Publishing date	2019-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2210518-9
ISSN	1746-1596 ; 1746-1596
ISSN (online)	1746-1596
ISSN	1746-1596
DOI	10.1186/s13000-019-0901-6
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Article ; Online: The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model.

Krajnović, Tamara / Drača, Dijana / Kaluđerović, Goran N / Dunđerović, Duško / Mirkov, Ivana / Wessjohann, Ludger A / Maksimović-Ivanić, Danijela / Mijatović, Sanja

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2019 Volume 129, Page(s) 257–268

Abstract: Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo ... ...

Abstract	Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, gained increasing attention as a potential chemopreventive agent. In the present study, IXN antimetastatic potential in vitro against the highly invasive melanoma cell line B16-F10 and in vivo in a murine metastatic model was investigated. Melanoma cell viability was diminished in a dose-dependent manner following the treatment with IXN. This decrease was a consequence of autophagy and caspase-dependent apoptosis. Additionally, the dividing potential of highly proliferative melanoma cells was dramatically affected by this isoflavanone, which was in correlation with an abrogated cell colony forming potential, indicating changes in their metastatic features. Concordantly, IXN promoted strong suppression of the processes that define metastasis- cell adhesion, invasion, and migration. Further investigation at the molecular level revealed that the abolished metastatic potential of a melanoma subclone was due to disrupted integrin signaling. Importantly, these results were reaffirmed in vivo where IXN inhibited the development of lung metastatic foci in tumor-challenged animals. The results of the present study may highlight the beneficial effects of IXN on melanoma as the most aggressive type of skin cancer and will hopefully shed a light on the possible use of this prenylflavonoid in the treatment of metastatic malignancies.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Adhesion/drug effects ; Cell Line, Tumor ; Humulus/chemistry ; Lung Neoplasms/prevention & control ; Lung Neoplasms/secondary ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Xanthones/pharmacology
Chemical Substances	Xanthones ; isoxanthohumol
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2019.04.046
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