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  1. Book ; Online: Addressing New Therapeutic Strategies Using Models

    Faustino, Ana / Oliveira, Paula A

    2023  

    Keywords Research & information: general ; Biology, life sciences ; spontaneous models ; induced models ; genetically engineered models ; acute kidney injury ; biomarkers ; coagulation ; ischemia-reperfusion injury ; shock ; newborn lamb ; multiple intestinal loop model ; 3R ; Cryptosporidium parvum ; yeast cell wall fractions ; fatty liver disease ; glucose ; imipramine ; insulin ; obesity ; renal impairment ; retinal injury ; xenograft ; ectopic ; orthotopic ; hIBC ; cIMC ; whole-body ischemia ; cardiopulmonary resuscitation ; drug-induced hypothermia ; spinal motor neuron ; inflammation ; paraplegia ; virucidal drugs ; IBV ; chickens ; Coronaviridae ; silver nanoparticles ; artificial ribonuclease ; monoglyceride lauryl acid ; spinal cord hemisection ; Macaca radiata ; predegenerated nerve transplantation ; locomotor recovery ; Cornu Ammonis 1 ; glutaminergic synapse ; memory function ; oligodendrocyte ; pyramidal cells ; animal model ; trichotillomania ; hair-pulling ; body-focused repetitive disorder ; transitional cell carcinoma ; urothelial carcinoma ; histology ; therapeutic marker ; prognosis ; mandibular growth ; mandibular posterior displacement ; mandibular length ; condylar growth ; rat ; class III malocclusion ; orthodontic treatment ; antebrachial growth deformity ; dog ; osteotomy ; patient-specific instrumentation ; 3-D ; n/a
    Language English
    Size 1 electronic resource (246 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030375483
    ISBN 9783036570822 ; 3036570829
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Prostate Cancer

    Faustino, Ana / Oliveira, Paula A

    2023  

    Keywords Research & information: general ; Biology, life sciences ; neurotoxicity ; testosterone ; androgen-deprivation therapy ; cognitive function ; sleep ; depression ; prostate cancer ; long noncoding RNA ; NEAT1 ; laser capture microdissection ; diagnostic algorithm ; prostate health index ; biopsy ; Gleason score ; magnetic resonance ; positron emission tomography ; diagnosis ; imaging ; prostate-specific membrane antigen ; radical prostatectomy ; pelvic lymph node dissection ; lymph node invasion ; preoperative nomogram ; bone metastasis ; lymph node metastasis ; liver metastasis ; gene expression ; meta-analysis ; focal adhesion ; protein filament ; androgen receptor signaling ; biomarker ; circulating tumor cells ; Wnt ; β-catenin ; Wnt5A ; breast cancer ; DKK1 ; radiomic features ; classification ; risk stratification ; computed tomography ; prostate ; cancer ; urine ; PUR ; PUR-4 ; Gleason pattern 4 ; STEAP1 ; DNA methylation ; histone deacetylation ; bioinformatics ; Circulating Tumor Cell (CTC) ; prostate cancer (PCa) ; liquid biopsy ; cancer recurrence
    Language English
    Size 1 electronic resource (150 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722289
    ISBN 9783036570846 ; 3036570845
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Osteoarthritis in the 21st century - a new paradigm: Osteoarthritis and Osteoarthrosis.

    Faustino, Augusto

    Acta reumatologica portuguesa

    2021  Volume 46, Issue 3, Page(s) 205–207

    Title translation Osteoarthritis in the 21st century – a new paradigm: Osteoarthritis and Osteoarthrosis.
    MeSH term(s) Humans ; Osteoarthritis
    Language English
    Publishing date 2021-10-28
    Publishing country Portugal
    Document type Editorial
    ZDB-ID 442031-7
    ISSN 0303-464X
    ISSN 0303-464X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Reuma.pt - the start and the purpose.

    Faustino, Augusto

    Acta reumatologica portuguesa

    2018  Volume 43, Issue 1, Page(s) 6–7

    Title translation Reuma.pt – the start and the purpose.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Humans ; Portugal ; Registries ; Rheumatic Diseases/drug therapy
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2018-03-27
    Publishing country Portugal
    Document type Editorial
    ZDB-ID 442031-7
    ISSN 0303-464X
    ISSN 0303-464X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pectus excavatum with right ventricular compression-induced ventricular arrhythmias.

    Ferraz, Lisa / Carvalho, Diana / Carvalho, Simāo / Pacheco, Adriana / Faustino, Ana / Neves, Ana

    The British journal of cardiology

    2023  Volume 30, Issue 1, Page(s) 4

    Abstract: A 33-year-old woman, with palpitations since the age of 15, was referred to a cardiology consultation due to very frequent ventricular extrasystoles with morphology of left bundle branch block, inferior frontal axis, late precordial transition, rS in V1, ...

    Abstract A 33-year-old woman, with palpitations since the age of 15, was referred to a cardiology consultation due to very frequent ventricular extrasystoles with morphology of left bundle branch block, inferior frontal axis, late precordial transition, rS in V1, R in V6 and rS in DI. She had pectus excavatum. The cardiac magnetic resonance showed severe pectus excavatum associated with exaggerated cardiac levoposition, compression and deformation of the right cardiac chambers. However, the patient became pregnant, and follow-up was delayed.
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 1354589-9
    ISSN 1753-4313 ; 0969-6113
    ISSN (online) 1753-4313
    ISSN 0969-6113
    DOI 10.5837/bjc.2023.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Suggestion for a new bacteriophage genus for the Klebsiella pneumoniae phage vB_KpnS-Carvaje.

    Sousa, Jéssica C / Sillankorva, Sanna / Faustino, Alberta / Carvalho, Carla M

    Current genetics

    2022  Volume 68, Issue 3-4, Page(s) 393–406

    Abstract: This work describes the newly isolated Klebsiella pneumoniae phage vB_KpnS-Carvaje that presents unique features in relation to other phages reported to date. These findings provide new insights into the diversity and evolutionary pathways of Klebsiella ... ...

    Abstract This work describes the newly isolated Klebsiella pneumoniae phage vB_KpnS-Carvaje that presents unique features in relation to other phages reported to date. These findings provide new insights into the diversity and evolutionary pathways of Klebsiella phages. The genome characterization of the Carvaje phage revealed that its genome length is approximately 57 kb with 99 open reading frames (ORFs), 33 of which have assigned functions while 66 are unknown. This phage differs from other sequenced Klebsiella phages, showing the closest resemblance (up to 65.32%) with Salmonella phages belonging to the Nonanavirus and Sashavirus genera. Comparisons at the amino acid level and phylogeny analysis among homologous genomes indicate that the Klebsiella Carvaje phage forms a novel sister taxon within the node of the Nonanaviruses and Sashaviruses cluster. Due to the unique features of the Carvaje phage, we propose the constitution of a new genus within the Caudoviricetes class. Further studies include the exploitation of this phage and its identified proteins for the control of Klebsiella infections and as recognition molecules in diagnostic methods.
    MeSH term(s) Bacteriophages/genetics ; Klebsiella pneumoniae/genetics ; Open Reading Frames/genetics ; Phylogeny
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-022-01242-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Characterization of MSlys, the endolysin of

    Silva, Maria Daniela / Oliveira, Hugo / Faustino, Alberta / Sillankorva, Sanna

    Biotechnology reports (Amsterdam, Netherlands)

    2020  Volume 28, Page(s) e00547

    Abstract: Despite the use of pneumococcal conjugate vaccines, the number of infections related ... ...

    Abstract Despite the use of pneumococcal conjugate vaccines, the number of infections related to
    Language English
    Publishing date 2020-10-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2801018-8
    ISSN 2215-017X
    ISSN 2215-017X
    DOI 10.1016/j.btre.2020.e00547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Intra- and Extra-Hospital Dissemination of IMP-22-Producing

    Gonçalves, Daniela / Cecílio, Pedro / Faustino, Alberta / Iglesias, Carmen / Branca, Fernando / Estrada, Alexandra / Ferreira, Helena

    Frontiers in microbiology

    2021  Volume 12, Page(s) 777054

    Abstract: The emergence of infections (and colonization) ... ...

    Abstract The emergence of infections (and colonization) with
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.777054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pseudomonas aeruginosa

    Pinto, Ana Mafalda / Faustino, Alberta / Pastrana, Lorenzo M / Bañobre-López, Manuel / Sillankorva, Sanna

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 7

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10070877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Confirmatory assays for transient changes of omics in soil invertebrates – Copper materials in a multigenerational exposure

    Bicho, Rita C / Faustino, A.M.R / Rêma, A / Scott-Fordsmand, Janeck J / Amorim, Mónica J.B

    Journal of hazardous materials. 2021 Jan. 15, v. 402

    2021  

    Abstract: Environmental risk assessment (ERA) based on effects caused by chronic and longer term exposure is highly relevant. Further, if mechanistic based approaches (e.g. omics) can be included, beyond apical endpoints (e.g. reproduction), the prediction of ... ...

    Abstract Environmental risk assessment (ERA) based on effects caused by chronic and longer term exposure is highly relevant. Further, if mechanistic based approaches (e.g. omics) can be included, beyond apical endpoints (e.g. reproduction), the prediction of effects increases. For Cu NMs (and CuCl₂) this has been studied in detail, covering multi-omics and apical effects using the soil standard species Enchytraeus crypticus. The intermediate level effects like cell/tissue and organ alterations represent a missing link. In the present study we aimed to: 1) perform long term exposure to Cu materials (full life cycle and multigeneration, 46 and 224 days) to collect samples; 2) perform histology and immunohistochemistry on collected samples at 12 time points and 17 treatments; 3) integrate all levels of biological organization onto an adverse outcome pathway (AOP) framework. CuO NMs and CuCl₂ caused both similar and different stress response, either at molecular initiating events (MIE) or key events (KEs) of higher level of biological organization. Cell/Tissue and organ level, post-transcriptional and transcriptional mechanisms, through histone modifications and microRNA related protein, were similarly affected. While both Cu forms affected the Notch signalling pathway, CuCl₂ also caused oxidative stress. Different mechanisms of DNA methylation (epigenetics) were activated by CuO NMs and CuCl₂ at the MIE.
    Keywords DNA methylation ; Enchytraeus ; adverse outcome pathways ; chronic exposure ; environmental assessment ; epigenetics ; histones ; immunohistochemistry ; microRNA ; multiomics ; oxidative stress ; prediction ; reproduction ; soil ; stress response ; transcription (genetics)
    Language English
    Dates of publication 2021-0115
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2020.123500
    Database NAL-Catalogue (AGRICOLA)

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