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Article ; Online: We asked the experts: Normalize challenges, build community, and develop mentorship: A guide for proactive institutional support for child rearing during surgical training.

Colley, Alexis / Yap, Ava / Trang, Karen / Kornblith, Lucy Z / Varma, Madhulika G / Vu, Lan

2024 Volume 48, Issue 3, Page(s) 524–526

MeSH term(s)	Humans ; Child ; Mentors ; Child Rearing ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Editorial
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1002/wjs.12095
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Zs.A 1336: Show issues

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Article ; Online: The intersection of coagulation activation and inflammation after injury: What you need to know.

Costantini, Todd W / Kornblith, Lucy Z / Pritts, Timothy / Coimbra, Raul

The journal of trauma and acute care surgery

2023 Volume 96, Issue 3, Page(s) 347–356

MeSH term(s)	Humans ; Blood Coagulation ; Inflammation
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004190
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Zs.A 127: Show issues

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Article ; Online: "Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Reply.

Matthay, Zachary A / Fields, Alexander T / Kornblith, Lucy Z

Journal of thrombosis and haemostasis : JTH

2022 Volume 20, Issue 11, Page(s) 2717–2718

MeSH term(s)	Humans ; Catecholamines ; Blood Platelets ; Platelet Aggregation Inhibitors
Chemical Substances	Catecholamines ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15869
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to Letter to the Editor submitted by Dr. Gando and Dr. Otomo re: Trauma-induced coagulopathy: The past, present, and future.

Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

Journal of thrombosis and haemostasis : JTH

2019 Volume 17, Issue 9, Page(s) 1569–1571

MeSH term(s)	Blood Coagulation Disorders ; Humans ; Wounds and Injuries
Language	English
Publishing date	2019-08-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.14533
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma-induced coagulopathy: The past, present, and future.

Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

Journal of thrombosis and haemostasis : JTH

2019 Volume 17, Issue 9, Page(s) 1574–1576

MeSH term(s)	Blood Coagulation Disorders ; Humans ; Wounds and Injuries
Language	English
Publishing date	2019-09-05
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.14581
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Trauma-induced coagulopathy: The past, present, and future.

Kornblith, Lucy Z / Moore, Hunter B / Cohen, Mitchell J

Journal of thrombosis and haemostasis : JTH

2019 Volume 17, Issue 6, Page(s) 852–862

Abstract: Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result ... ...

Abstract	Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result in hemostatic failure, which has been identified as a multidimensional molecular, physiologic and clinical disorder termed trauma-induced coagulopathy (TIC). Understanding the biology of TIC is of utmost importance, as it is often responsible for uncontrolled bleeding, organ failure, thromboembolic complications, and death. Investigations have shown that TIC is characterized by multiple phenotypes of impaired hemostasis due to altered biology in clot formation and breakdown. These coagulopathies are attributable to tissue injury and shock, and encompass underlying endothelial, immune and inflammatory perturbations. Despite the recognition and identification of multiple mechanisms and mediators of TIC, and the development of targeted treatments, the mortality rates and associated morbidities due to hemorrhage after injury remain high. The purpose of this review is to examine the past and present understanding of the multiple distinct but highly integrated pathways implicated in TIC, in order to highlight the current knowledge gaps and future needs in this evolving field, with the aim of reducing morbidity and mortality after injury.
MeSH term(s)	Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/etiology ; Blood Coagulation Factors/metabolism ; Blood Platelets/physiology ; Endothelium/metabolism ; Exsanguination/blood ; Exsanguination/etiology ; Fibrinolysis ; Hemorrhage/blood ; Hemorrhage/etiology ; Hemostasis ; Humans ; Protein C/metabolism ; Shock, Hemorrhagic/blood ; Shock, Hemorrhagic/etiology ; Wounds and Injuries/blood ; Wounds and Injuries/complications
Chemical Substances	Blood Coagulation Factors ; Protein C
Language	English
Publishing date	2019-05-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.14450
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.

Kornblith, Lucy Z / Sadhanandhan, Bindhya / Arun, Sreepriya / Long, Rebecca / Johnson, Alicia J / Noll, Jamie / Ramchand, C N / Olynyk, John K / Farrell, David H

Blood cells, molecules & diseases

2024 Volume 105, Page(s) 102825

MeSH term(s)	Humans ; Fibrinogen ; COVID-19/diagnosis ; Biomarkers ; Risk Factors ; Blood Coagulation Tests
Chemical Substances	Fibrinogen (9001-32-5) ; Biomarkers
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/j.bcmd.2024.102825
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Zs.A 1138: Show issues

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Article ; Online: A comparison of computational algorithms for the Bayesian analysis of clinical trials.

Chen, Ziming / Berger, Jeffrey S / Castellucci, Lana A / Farkouh, Michael / Goligher, Ewan C / Hade, Erinn M / Hunt, Beverley J / Kornblith, Lucy Z / Laweler, Patrick R / Leifer, Eric S / Lorenzi, Elizabeth / Neal, Matthew D / Zarychanski, Ryan / Heath, Anna

Clinical trials (London, England)

2024 , Page(s) 17407745241247334

Abstract: Background: Clinical trials are increasingly using Bayesian methods for their design and analysis. Inference in Bayesian trials typically uses simulation-based approaches such as Markov Chain Monte Carlo methods. Markov Chain Monte Carlo has high ... ...

Abstract	Background: Clinical trials are increasingly using Bayesian methods for their design and analysis. Inference in Bayesian trials typically uses simulation-based approaches such as Markov Chain Monte Carlo methods. Markov Chain Monte Carlo has high computational cost and can be complex to implement. The Integrated Nested Laplace Approximations algorithm provides approximate Bayesian inference without the need for computationally complex simulations, making it more efficient than Markov Chain Monte Carlo. The practical properties of Integrated Nested Laplace Approximations compared to Markov Chain Monte Carlo have not been considered for clinical trials. Using data from a published clinical trial, we aim to investigate whether Integrated Nested Laplace Approximations is a feasible and accurate alternative to Markov Chain Monte Carlo and provide practical guidance for trialists interested in Bayesian trial design. Methods: Data from an international Bayesian multi-platform adaptive trial that compared therapeutic-dose anticoagulation with heparin to usual care in non-critically ill patients hospitalized for COVID-19 were used to fit Bayesian hierarchical generalized mixed models. Integrated Nested Laplace Approximations was compared to two Markov Chain Monte Carlo algorithms, implemented in the software JAGS and stan, using packages available in the statistical software R. Seven outcomes were analysed: organ-support free days (an ordinal outcome), five binary outcomes related to survival and length of hospital stay, and a time-to-event outcome. The posterior distributions for the treatment and sex effects and the variances for the hierarchical effects of age, site and time period were obtained. We summarized these posteriors by calculating the mean, standard deviations and the 95% equitailed credible intervals and presenting the results graphically. The computation time for each algorithm was recorded. Results: The average overlap of the 95% credible interval for the treatment and sex effects estimated using Integrated Nested Laplace Approximations was 96% and 97.6% compared with stan, respectively. The graphical posterior densities for these effects overlapped for all three algorithms. The posterior mean for the variance of the hierarchical effects of age, site and time estimated using Integrated Nested Laplace Approximations are within the 95% credible interval estimated using Markov Chain Monte Carlo but the average overlap of the credible interval is lower, 77%, 85.6% and 91.3%, respectively, for Integrated Nested Laplace Approximations compared to stan. Integrated Nested Laplace Approximations and stan were easily implemented in clear, well-established packages in R, while JAGS required the direct specification of the model. Integrated Nested Laplace Approximations was between 85 and 269 times faster than stan and 26 and 1852 times faster than JAGS. Conclusion: Integrated Nested Laplace Approximations could reduce the computational complexity of Bayesian analysis in clinical trials as it is easy to implement in R, substantially faster than Markov Chain Monte Carlo methods implemented in JAGS and stan, and provides near identical approximations to the posterior distributions for the treatment effect. Integrated Nested Laplace Approximations was less accurate when estimating the posterior distribution for the variance of hierarchical effects, particularly for the proportional odds model, and future work should determine if the Integrated Nested Laplace Approximations algorithm can be adjusted to improve this estimation.
Language	English
Publishing date	2024-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2138796-5
ISSN	1740-7753 ; 1740-7745
ISSN (online)	1740-7753
ISSN	1740-7745
DOI	10.1177/17407745241247334
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Zs.A 5831: Show issues

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Article ; Online: Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial.

Walborn, Amanda T / Heath, Anna / Neal, Matthew D / Zarychanski, Ryan / Kornblith, Lucy Z / Hunt, Beverley J / Castellucci, Lana A / Hochman, Judith S / Lawler, Patrick R / Paul, Jonathan D

Research and practice in thrombosis and haemostasis

2023 Volume 7, Issue 7, Page(s) 102203

Abstract: Background: Patients hospitalized for COVID-19 are at high risk of thrombotic complications and organ failure, and often exhibit severe inflammation, which may contribute to hypercoagulability.: Objectives: To determine whether patients hospitalized ... ...

Abstract	Background: Patients hospitalized for COVID-19 are at high risk of thrombotic complications and organ failure, and often exhibit severe inflammation, which may contribute to hypercoagulability. Objectives: To determine whether patients hospitalized for COVID-19 experience differing frequencies of thrombotic and organ failure complications and derive variable benefits from therapeutic-dose heparin dependent on the extent of systemic inflammation and whether observed benefit from therapeutic-dose anticoagulation varies depending on the degree of systemic inflammation. Methods: We analyzed data from 1346 patients hospitalized for COVID-19 enrolled in the ATTACC and ACTIV-4a platforms who were randomized to therapeutic-dose heparin or usual care for whom levels of C-reactive protein (CRP) were reported at baseline. Results: Increased CRP was associated with worse patient outcomes, including a >98% posterior probability of increased organ support requirement, hospital length of stay, risk of 28-day mortality, and incidence of major thrombotic events or death (patients with CRP 40-100 mg/L or ≥100 mg/L compared to patients with CRP <40 mg/L). Patients with CRP 40 to 100 mg/L experienced the greatest degree of benefit from treatment with therapeutic doses of unfractionated or low molecular weight heparin compared with usual-care prophylactic doses. This was most significant for an increase in organ support-free days (odds ratio: 1.63; 95% confidence interval, 1.09-2.40; 97.9% posterior probability of beneficial effect), with trends toward benefit for other evaluated outcomes. Conclusion: Moderately ill patients hospitalized for COVID-19 with CRP between 40 mg/L and 100 mg/L derived the greatest benefit from treatment with therapeutic-dose heparin.
Language	English
Publishing date	2023-09-16
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2023.102203
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Article ; Online: Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.

Matthay, Zachary A / Fields, Alexander T / Wick, Katherine D / Jones, Chayse / Lane, H Clifford / Herrera, Kimberly / Nuñez-Garcia, Brenda / Gennatas, Efstathios / Hendrickson, Carolyn M / Kornblith, Aaron E / Matthay, Michael A / Kornblith, Lucy Z

Frontiers in immunology

2023 Volume 14, Page(s) 1130821

Abstract: Introduction: There remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association ... ...

Abstract	Introduction: There remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association of receptor for advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and a panel of thromboinflammatory biomarkers with development of severe disease in patients presenting to the emergency department with symptomatic COVID-19. Methods: Blood samples were collected on arrival from 77 patients with symptomatic COVID-19, and plasma levels of thromboinflammatory biomarkers were measured. Results: Differences in biomarkers between those who did and did not develop severe disease or death 7 days after presentation were analyzed. After adjustment for multiple comparisons, RAGE, SARS-CoV-2 nucleocapsid viral antigen, interleukin (IL)-6, IL-10 and tumor necrosis factor receptor (TNFR)-1 were significantly elevated in the group who developed severe disease (all Discussion: Elevated RAGE and SARS-CoV-2 nucleocapsid viral antigen on emergency department presentation are strongly associated with development of severe disease at 7 days. These findings are of clinical relevance for patient prognostication and triage as hospital systems continue to be overwhelmed. Further studies are warranted to determine the feasibility and utility of point-of care measurements of these biomarkers in the emergency department setting to improve patient prognostication and triage.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Receptor for Advanced Glycation End Products ; Nucleocapsid ; Antigens ; Biomarkers ; Antigens, Viral
Chemical Substances	Receptor for Advanced Glycation End Products ; Antigens ; Biomarkers ; Antigens, Viral
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1130821
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