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  1. AU="Pierce, Aimee"
  2. AU="Luque-Ballesteros, Laura"
  3. AU="Dondi, Francesco"
  4. AU="McLachlan, Alex"
  5. AU="Krizova, Ludmila"
  6. AU="Balog, Attila"
  7. AU="Faerber, Karin"
  8. AU="Prettner, Klaus"
  9. AU="Ambrožová, I."
  10. AU="William, Doreen"
  11. AU="Gutiérrez-Sánchez, A M"
  12. AU="Bohan, Dana"
  13. AU="Spracklen, D."
  14. AU="Lobo, Brian C"
  15. AU=Zhuang Jianjian AU=Zhuang Jianjian
  16. AU=Pathanki Adithya M
  17. AU="Armando Vilchis-Ordoñez"
  18. AU="Zhongfu Lu"
  19. AU="Lo, Hong-Yip"
  20. AU="Ziman Xiong"
  21. AU="Oakes, Allison H"
  22. AU="Ma, Shaotong"
  23. AU="Zang, Lili"
  24. AU="Adams Brian D"
  25. AU="Maria Papaioannou"
  26. AU="Kollia, Georgia"
  27. AU="Auxiette, Catherine"
  28. AU="Guzmán, Luis"
  29. AU="Alipour, Elnaz"
  30. AU="Queiroz, Dayanna Joyce Marques"
  31. AU="Ramamurthy, Santosh"
  32. AU="Xueying Huang"
  33. AU="Cromwell, Howard C"
  34. AU="Spence, John C H"
  35. AU="Chapinal, Libertad"
  36. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  37. AU=Hempel Cornelius

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Treffer 1 - 10 von insgesamt 20

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  1. Artikel ; Online: Patient management problem.

    Pierce, Aimee

    Continuum (Minneapolis, Minn.)

    2013  Band 19, Heft 2 Dementia, Seite(n) 519–537

    Mesh-Begriff(e) Alzheimer Disease/diagnosis ; Alzheimer Disease/therapy ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/therapy ; Disease Management ; Disease Progression ; Humans ; Male ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2013-05-15
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/01.CON.0000429166.97320.81
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study.

    Lindauer, Allison / Croff, Raina / Duff, Kevin / Mattek, Nora / Fuller, Patrice / Pierce, Aimee / Johnson, Kalisha Bonds / Kaye, Jeffrey

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Objectives: The vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe the study design ... ...

    Abstract Objectives: The vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe the study design and baseline characteristics of the African American Dementia and Aging Project (AADAPt) study, which is exploring aging and cognition in African American older adults in Oregon.
    Methods: African American older adults (n=177) participated in AADAPt, a longitudinal study that collected data on cognitive, physical, and social functioning in annual visits since 2000.
    Results: AADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement.
    Conclusions: The AADAPt project offers new insights into aging in older African Americans that includes data on cognition, social engagement, and physical health, which are crucial for understanding the experience of under-represented groups and making future studies more inclusive.
    Clinical implications: These findings reflect a window of time for a geographically-focused cohort, and the lessons learned from this study likely have broader implications for shaping the health of these older African American adults.
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.05.06.24306831
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Dementia in the oldest old: Beyond Alzheimer disease.

    Pierce, Aimee L / Kawas, Claudia H

    PLoS medicine

    2017  Band 14, Heft 3, Seite(n) e1002263

    Abstract: In a Perspective, Aimee Pierce and Claudia Kawas discuss risk factors and pathologies of dementia in the oldest-old. ...

    Abstract In a Perspective, Aimee Pierce and Claudia Kawas discuss risk factors and pathologies of dementia in the oldest-old.
    Mesh-Begriff(e) Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/etiology ; Dementia/epidemiology ; Dementia/etiology ; Humans ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2017-03-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1002263
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Patient Portal Use Among Diabetic Patients With Different Races and Ethnicities.

    Wang, Hao / Kirby, Ryan / Pierce, Aimee / Barbaro, Michael / Ho, Amy F / Blalock, Jake / Schrader, Chet D

    Journal of clinical medicine research

    2022  Band 14, Heft 10, Seite(n) 400–408

    Abstract: Background: Patient portal (PP) use varies among different patient populations, specifically among those with diabetes mellitus (DM). In addition, it is still uncertain whether PP use could be linked to improved clinical outcomes. Therefore, the aim of ... ...

    Abstract Background: Patient portal (PP) use varies among different patient populations, specifically among those with diabetes mellitus (DM). In addition, it is still uncertain whether PP use could be linked to improved clinical outcomes. Therefore, the aim of this paper was to determine PP use status for patients, recognize factors promoting PP use, and further identify the association between PP use and clinical outcome among diabetic patients of different races and ethnicities.
    Methods: This was a single-center cross-section study. Patients were divided into non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic/Latino groups. PP use was compared among these three groups. Multivariate logistic regressions were used to determine factors associated with PP use, serum glycemic control, and emergency department (ED) hospitalizations.
    Results: A total of 77,977 patients were analyzed. The rate of PP use among patients of NHW (24%) was higher than those of NHB (19%) and Hispanic/Latinos (18%, P < 0.0001). The adjusted odds ratio (AOR) of insurance coverage associated with PP use was 2.12 (2.02 - 2.23, P < 0.0001), and having a primary care physician (PCP) associated with PP use was 3.89 (3.71 - 4.07, P < 0.0001). In terms of clinical outcomes, the AOR of PP use associated with serum glycemic control was 0.98 (0.90 - 1.05, P = 0.547) and ED hospitalization was 0.79 (0.73 - 0.86, P < 0.0001).
    Conclusion: PP use disparity occurred among NHB and Hispanic/Latino patients in the ED. Having insurance coverage and PCPs seem to correlate with PP use. PP use did not seem to associate with serum glycemic control among DM patients present in the ED but could possibly reduce patient hospitalizations.
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr4822
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Late-Onset Alzheimer Disease.

    Pierce, Aimee L / Bullain, Szofia S / Kawas, Claudia H

    Neurologic clinics

    2017  Band 35, Heft 2, Seite(n) 283–293

    Abstract: The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease ( ... ...

    Abstract The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.
    Mesh-Begriff(e) Age of Onset ; Aging ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Dementia/pathology ; Dementia/physiopathology ; Humans
    Sprache Englisch
    Erscheinungsdatum 2017-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2017.01.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia.

    Sheikh-Bahaei, Nasim / Sajjadi, Seyed Ahmad / Pierce, Aimee L

    Current treatment options in neurology

    2017  Band 19, Heft 12, Seite(n) 46

    Abstract: Purpose of review Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI. However, there are certain circumstances ... ...

    Abstract Purpose of review Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI. However, there are certain circumstances wherein detection of specific biomarkers of neurodegeneration or underlying AD pathology will impact the clinical diagnosis or treatment plan. We will review the currently available biomarkers for AD and frontotemporal dementia (FTD) and discuss their clinical importance. Recent findings With the advent of
    Sprache Englisch
    Erscheinungsdatum 2017-11-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-017-0484-z
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  7. Artikel ; Online: Attitudes toward Potential Participant Registries.

    Grill, Joshua D / Holbrook, Andrew / Pierce, Aimee / Hoang, Dan / Gillen, Daniel L

    Journal of Alzheimer's disease : JAD

    2017  Band 56, Heft 3, Seite(n) 939–946

    Abstract: Difficult participant recruitment is a consistent barrier to successful medical research. Potential participant registries represent an increasingly common intervention to overcome this barrier. A variety of models for registries exist, but few data are ... ...

    Abstract Difficult participant recruitment is a consistent barrier to successful medical research. Potential participant registries represent an increasingly common intervention to overcome this barrier. A variety of models for registries exist, but few data are available to instruct their design and implementation. To provide such data, we surveyed 110 cognitively normal research participants enrolled in a longitudinal study of aging and dementia. Seventy-four (67%) individuals participated in the study. Most (78%, CI: 0.67, 0.87) participants were likely to enroll in a registry. Willingness to participate was reduced for registries that required enrollment through the Internet using a password (26%, CI: 0.16, 0.36) or through email (38%, CI: 0.27, 0.49). Respondents acknowledged their expectations that researchers share information about their health and risk for disease and their concerns that their data could be shared with for-profit companies. We found no difference in respondent preferences for registries that shared contact information with researchers, compared to honest broker models that take extra precautions to protect registrant confidentiality (28% versus 30%; p = 0.46). Compared to those preferring a shared information model, respondents who preferred the honest broker model or who lacked model preference voiced increased concerns about sharing registrant data, especially with for-profit organizations. These results suggest that the design of potential participant registries may impact the population enrolled, and hence the population that will eventually be enrolled in clinical studies. Investigators operating registries may need to offer particular assurances about data security to maximize registry enrollment but also must carefully manage participant expectations.
    Mesh-Begriff(e) Aged ; Aging ; Attitude ; Biomedical Research ; Confidentiality ; Dementia/epidemiology ; Female ; Follow-Up Studies ; Humans ; Internet ; Longitudinal Studies ; Male ; Registries ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2017-01-05
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-160873
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Participant Satisfaction With Learning Alzheimer Disease Clinical Trial Results.

    Pierce, Aimee L / Cox, Chelsea G / Nguyen, Huong T / Hoang, Dan / Witbracht, Megan / Gillen, Daniel L / Grill, Joshua D

    Alzheimer disease and associated disorders

    2018  Band 32, Heft 4, Seite(n) 366–368

    Mesh-Begriff(e) Aged ; Alzheimer Disease/drug therapy ; Antibodies, Monoclonal, Humanized/administration & dosage ; Clinical Trials as Topic ; Female ; Humans ; Interviews as Topic ; Patient Satisfaction ; Treatment Outcome
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; solanezumab (5D6PWO0333)
    Sprache Englisch
    Erscheinungsdatum 2018-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000258
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  9. Artikel ; Online: Retention of Alzheimer Disease Research Participants.

    Grill, Joshua D / Kwon, Jimmy / Teylan, Merilee A / Pierce, Aimee / Vidoni, Eric D / Burns, Jeffrey M / Lindauer, Allison / Quinn, Joseph / Kaye, Jeff / Gillen, Daniel L / Nan, Bin

    Alzheimer disease and associated disorders

    2019  Band 33, Heft 4, Seite(n) 299–306

    Abstract: Introduction: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.: Methods: We surveyed representative investigators from NIH- ... ...

    Abstract Introduction: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.
    Methods: We surveyed representative investigators from NIH-funded Alzheimer's Disease Research Centers (ADRC), querying their use of retention tactics across 12 strategies. We compared survey results to data from the National Alzheimer's Coordinating Center for each center. We used a generalized estimating equation with independent working covariance model and empirical standard errors to assess relationships between survey results and rates of retention, controlling for participant characteristics.
    Results: Twenty-five (83%) responding ADRCs employed an average 42 (SD=7) retention tactics. In a multivariable model that accounted for participant characteristics, the number of retention tactics used by a center was associated with participant retention (odds ratio=1.68, 95% confidence interval: 1.42, 1.98; P<0.001 for the middle compared with the lowest tertile survey scores; odds ratio=1.59, 95% confidence interval: 1.30, 1.94; P<0.001 for the highest compared with the lowest tertile survey scores) at the first follow-up visit. Participant characteristics such as normal cognition diagnosis, older age, higher education, and Caucasian race were also associated with higher retention.
    Conclusions: Retention in clinical research is more likely to be achieved by employing a variety of tactics.
    Mesh-Begriff(e) Aged ; Alzheimer Disease/psychology ; Biomedical Research ; Clinical Trials as Topic ; Female ; Humans ; Male ; Motivation ; Patient Selection ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2019-09-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000353
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Combining brain imaging with microarray: isolating molecules underlying the physiologic disorders of the brain.

    Pierce, Aimee / Small, Scott A

    Neurochemical research

    2004  Band 29, Heft 6, Seite(n) 1145–1152

    Abstract: Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy--including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The ... ...

    Abstract Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy--including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The absence of clear anatomical markers makes it difficult to identify targeted cells, which in turn impedes attempts to isolate the pathogenic molecules that cause physiologic disruption. Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Aging ; Brain/anatomy & histology ; Brain/growth & development ; Brain/pathology ; Brain Diseases/genetics ; Brain Diseases/physiopathology ; Humans ; Middle Aged ; Oligonucleotide Array Sequence Analysis/methods ; Transcription, Genetic
    Sprache Englisch
    Erscheinungsdatum 2004-05-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1023/b:nere.0000023601.50101.7f
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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