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Article: Monitoring and molecular characterization of bacterial species in heavy metals contaminated roadside soil of selected region along NH 8A, Gujarat.

Singh, Snigdha / Hiranmai, R Y

2021 Volume 7, Issue 11, Page(s) e08284

Abstract: Heavy metal contamination is a universal concern due to health risks associated with metal pollution. Soil contamination by heavy metals is known to affect microbial activities at elevated concentrations adversely. However, indigenous soil bacterial ... ...

Abstract	Heavy metal contamination is a universal concern due to health risks associated with metal pollution. Soil contamination by heavy metals is known to affect microbial activities at elevated concentrations adversely. However, indigenous soil bacterial populations' response to added heavy metal and metal combinations is poorly understood. Microbes prevailing in the soil are the driving factors. Their properties are recognized as sensitive indicators of soil quality and health. Moreover, these microscopic organisms are accountable for the fertility and aeration of the soil that forms fundamental aspects of soil function. The current study was performed to explore the diversity of bacterial species in heavy metal polluted roadside soil. The roadside soil samples were collected from diverse sites and processed for physicochemical properties, microbial characterization, and heavy metals distribution in the selected locations. Serial dilution and spread plate techniques were used for the isolation of bacterial species. The 16S-rRNA gene sequencing identified bacterial species in roadside soil as
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08284
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Article: Monitoring and molecular characterization of bacterial species in heavy metals contaminated roadside soil of selected region along NH 8A, Gujarat

Singh, Snigdha / Hiranmai, R.Y.

Heliyon. 2021 Nov., v. 7, no. 11

2021

Abstract	Heavy metal contamination is a universal concern due to health risks associated with metal pollution. Soil contamination by heavy metals is known to affect microbial activities at elevated concentrations adversely. However, indigenous soil bacterial populations' response to added heavy metal and metal combinations is poorly understood. Microbes prevailing in the soil are the driving factors. Their properties are recognized as sensitive indicators of soil quality and health. Moreover, these microscopic organisms are accountable for the fertility and aeration of the soil that forms fundamental aspects of soil function. The current study was performed to explore the diversity of bacterial species in heavy metal polluted roadside soil. The roadside soil samples were collected from diverse sites and processed for physicochemical properties, microbial characterization, and heavy metals distribution in the selected locations. Serial dilution and spread plate techniques were used for the isolation of bacterial species. The 16S-rRNA gene sequencing identified bacterial species in roadside soil as Bacillus drentensis (MK217088), Bacillus safensis (MK774729), Bacillus haynesii (MK192808), Bacillus subtilis (MK217089), and Bacillus cereus (MK801278). In addition, the 16S rRNA sequences of isolated bacterial strains were aligned to generate a phylogenetic tree. Thus, the current research study provides a platform for efficiently investigating roadside soils by microbial profiling that may discover novel microbes of scientific significance and improved potential.
Keywords	Bacillus cereus ; Bacillus safensis ; Bacillus subtilis ; aeration ; genes ; heavy metals ; phylogeny ; roadside soils ; roadsides ; soil bacteria ; soil function ; soil pollution ; soil quality ; India
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08284
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Article ; Online: Design and development of efficient and compact 20 kW 325 MHz solid-state amplifier for superconducting accelerator applications.

Mishra, Jitendra Kumar / Singh, Snigdha / Shrotriya, Sandip / Ramarao, B V / Pande, Manjiri / Joshi, Gopal

The Review of scientific instruments

2024 Volume 95, Issue 5

Abstract: An efficient and compact, 20 kW solid-state power amplifier (SSA) at 325 MHz has been designed and developed in-house, using single stage combining. It comprises of 24 nos. of 1 kW power amplifier (PA) modules, a 24-way Wilkinson power combiner and ... ...

Abstract	An efficient and compact, 20 kW solid-state power amplifier (SSA) at 325 MHz has been designed and developed in-house, using single stage combining. It comprises of 24 nos. of 1 kW power amplifier (PA) modules, a 24-way Wilkinson power combiner and divider, and other peripheral systems. The typical gain and conversion efficiency of the PA modules at 1.0 kW output is 21.7 dB and 66.6%, respectively. It is demonstrated that overall power gain and AC to RF efficiency of this SSA at 20 kW is 88.5 dB and 54.8%, respectively, which matches closely with the design estimates. The harmonic content in the RF output is < -40 dBc for all the harmonics. The results of the Monte Carlo simulation are also presented, showing lower bound on combining efficiency with a degree of confidence if magnitude and phase data for 24 inputs are randomly chosen from a normal distribution's pre-defined interval. The salient features of this SSA include power density of 12.7 kW/m3, AC to RF efficiency of 54.8% at 20 kW, and guaranteed output of 20 kW with one failed PA module and 18.1 kW under two failed PA modules condition.
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0193482
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Article: Primary Laryngeal Aspergillosis - Case Series, Reported in a Tertiary Care Hospital, Bhubaneswar, Odisha, India.

Panda, Nishant / Singh, Snigdha / Pradhan, Nishikanta

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2022 Volume 75, Issue 2, Page(s) 917–920

Abstract: We report 2 vocal fold aspergillosis cases from Otolaryngology department of a tertiary hospital, Bhubaneswar. A 26 years old female visited the OPD with chief complaint of progressive hoarseness and pain while talking since 6 months. While another 29 ... ...

Abstract	We report 2 vocal fold aspergillosis cases from Otolaryngology department of a tertiary hospital, Bhubaneswar. A 26 years old female visited the OPD with chief complaint of progressive hoarseness and pain while talking since 6 months. While another 29 years old female complained of having progressive hoarseness since 4 months preceded by an episode of sore throat. Both cases had microlaryngeal surgery/ endo laryngeal surgery followed by excisional biopsy.
Language	English
Publishing date	2022-10-03
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-022-03207-w
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Article ; Online: Visible Light-Prompted Regioselective Synthesis of Novel 5-Aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazoles as DNA- and BSA-Targeting Agents.

Aggarwal, Ranjana / Jain, Naman / Dubey, Gyan Prakash / Singh, Snigdha / Chandra, Ramesh

Biomacromolecules

2023 Volume 24, Issue 11, Page(s) 4798–4818

Abstract: Organic transformations mediated by visible light have gained popularity in recent years as they are green, renewable, inexpensive, and clean and yield excellent products. The present study describes cyclo-condensation of 2-methylthiazole-4- ... ...

Abstract	Organic transformations mediated by visible light have gained popularity in recent years as they are green, renewable, inexpensive, and clean and yield excellent products. The present study describes cyclo-condensation of 2-methylthiazole-4-carbothioamide with differently substituted α-bromo-1,3-diketones achieved by utilizing a white light-emitting diode (LED) (9W) to accomplish the regioselective synthesis of novel 5-aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazole derivatives as DNA/bovine serum albumin (BSA)-targeting agents. The structure characterization of the exact regioisomer was achieved unequivocally by heteronuclear two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy [
MeSH term(s)	Binding Sites ; Serum Albumin, Bovine/chemistry ; Molecular Docking Simulation ; Spectrometry, Fluorescence ; Protein Binding ; DNA/chemistry ; Circular Dichroism ; Thermodynamics ; Spectrophotometry, Ultraviolet
Chemical Substances	Serum Albumin, Bovine (27432CM55Q) ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c00554
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Article ; Online: Recent advancements on

Singh, Snigdha / Agrawal, Mukta / Vashist, Rajat / Patel, Rohit K / Sangave, Sanchita Dhanchandra / Alexander, Amit

Expert opinion on drug delivery

2023 Volume 20, Issue 12, Page(s) 1839–1857

Abstract: Introduction: The efficiency of brain therapeutics is greatly hindered by the blood-brain barrier (BBB). BBB's protective function, selective permeability, and dynamic functionality maintain the harmony between the brain and peripheral region. Thus, the ...

Abstract	Introduction: The efficiency of brain therapeutics is greatly hindered by the blood-brain barrier (BBB). BBB's protective function, selective permeability, and dynamic functionality maintain the harmony between the brain and peripheral region. Thus, the design of any novel drug carrier system requires the complete study and investigation of BBB permeability, efflux transport, and the effect of associated cellular and non-vascular unit trafficking on BBB penetrability. The in vitro BBB models offer a most promising, and reliable mode of initial investigation of BBB permeability and associated factors as strong evidence for further preclinical and clinical investigation. Area covered: This review work covers the structure and functions of BBB components and different types of in vitro BBB models along with factors affecting BBB model development and model selection criteria. Expert opinion: In vivo models assume to reciprocate the physiological environment to the maximum extent. However, the interspecies variability, NVUs trafficking, dynamic behavior of BBB, etc., lead to non-reproducible results. The in vitro models are comparatively less complex, and flexible, as per the study design, could generate substantial evidence and help identify suitable in vivo animal model selection.
MeSH term(s)	Animals ; Blood-Brain Barrier ; Brain ; Biological Transport ; Endothelial Cells ; Permeability
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2023.2295940
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Article ; Online: An expeditious on-water regioselective synthesis of novel arylidene-hydrazinyl-thiazoles as DNA targeting agents.

Aggarwal, Ranjana / Hooda, Mona / Kumar, Prince / Kumar, Suresh / Singh, Snigdha / Chandra, Ramesh

Bioorganic chemistry

2023 Volume 136, Page(s) 106524

Abstract: A series of twenty novel (E)-arylidene-hydrazinyl-thiazole derivatives has been synthesized employing α-bromo-β-diketones, thiosemicarbazide, and aromatic/heteroaromatic aldehydes with a simple and facile one-pot multicomponent reaction passageway. This ... ...

Abstract	A series of twenty novel (E)-arylidene-hydrazinyl-thiazole derivatives has been synthesized employing α-bromo-β-diketones, thiosemicarbazide, and aromatic/heteroaromatic aldehydes with a simple and facile one-pot multicomponent reaction passageway. This organic transformation proceeds efficiently in aqueous media and demonstrated a large functional group tolerance. The structures and stereochemistry of the regioisomeric product were rigorously characterized using heteronuclear 2D NMR experiments. The binding potential of the synthesized analogs with B-DNA dodecamer d(CGCGAATTCGCG)
MeSH term(s)	Thermodynamics ; Nucleic Acid Conformation ; DNA/chemistry ; Models, Molecular ; Circular Dichroism ; Spectrometry, Fluorescence ; Molecular Docking Simulation
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106524
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Article: Osteonecrosis of the Jaws: An Update and Review of Literature.

Kalita, Flora / Gupta, Durga Shanker / Gehlot, Neelima / Mitra, Subhajit / Singh, Snigdha / Pillai, Sooraj S

Journal of maxillofacial and oral surgery

2023 Volume 22, Issue 2, Page(s) 344–351

Abstract: Aim: To provide a concise review on risk factors, stages, pathophysiology, prevention and possible treatment options for both MRONJ and ORN individually.: Methods: The review was conducted according to the 'Preferred Reporting Items for Systematic ... ...

Abstract	Aim: To provide a concise review on risk factors, stages, pathophysiology, prevention and possible treatment options for both MRONJ and ORN individually. Methods: The review was conducted according to the 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' (PRISMA) guidelines. A comprehensive search of the PUBMED, Ebsco, SCOPUS, WEB OF SCIENCE and NDH for articles published up until 2021 was performed. After screening and full text analyses, 44 studies were included in this review. Definition, risk factors, etiology, symptoms, stages, pathophysiology, prevention and possible management options were explored and highlighted in this article. Results: Three studies described osteonecrosis of jaw (ONJ) in general, 15 studies described ONJ associated with radiotherapy and 26 studies described ONJ associated with medications. Both the two conditions (ORN) and (MRONJ) have relatively similar clinical presentations clearing the fact that a resemblance in clinical presentations does not necessarily denote a similar pathophysiology. Conclusion: However, various advancements have been made in the control and management of ONJ, but until and unless need for high tumoricidal doses exists, ONJ will certainly continue to remain as a clinical challenge demanding satisfactory treatment to improve the quality of life of the patient.
Language	English
Publishing date	2023-03-05
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-023-01876-w
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Article ; Online: In vitro

Singh, Anurag Kumar / Singh, Snigdha / Minocha, Tarun / Yadav, Sanjeev Kumar / Narayan, Reema / Nayak, Usha Yogendra / Singh, Santosh Kumar / Awasthi, Rajendra

Nanoscale advances

2024 Volume 6, Issue 9, Page(s) 2469–2486

Abstract: Neuronal loss in Alzheimer's disease has been reported to display features of apoptosis, pyroptosis (programmed necrosis), or necroptosis. This study thoroughly examines the production and characterization of MCM-41 based berberine (BBR)-loaded porous ... ...

Abstract	Neuronal loss in Alzheimer's disease has been reported to display features of apoptosis, pyroptosis (programmed necrosis), or necroptosis. This study thoroughly examines the production and characterization of MCM-41 based berberine (BBR)-loaded porous silica nanoparticles (MSNs) by a modified Stöber method, focusing on their possible role in inhibiting the apoptotic process. Particle size, polydispersity index, morphology, drug loading, zeta potential, entrapment efficiency, and drug release were examined. The formulation was analyzed using various spectroscopic techniques. The surface area was computed by the Brunauer-Emmett-Teller plot. Computational models were developed for molecular dynamics simulation studies. A small PDI value indicated an even distribution of particles at nanoscale sizes (80-100 nm). Results from XRD and SEAD experiments confirmed the amorphous nature of BBR in nanoparticles. Nanoparticles had high entrapment (75.21 ± 1.55%) and drug loading (28.16 ± 2.5%) efficiencies. A negative zeta potential value (-36.861.1 mV) indicates the presence of silanol groups on the surface of silica. AFM findings reveal bumps due to the surface drug that contributed to the improved roughness of the MSNs-BBR surface. Thermal gravimetric analysis confirmed the presence of BBR in MSNs. Drug release was controlled by simple diffusion or quasi-diffusion. Molecular dynamics simulations confirmed the existence of diffused drug molecules. Cellular studies using SH-SY-5Y cells revealed dose-dependent growth inhibition. Fragmented cell nuclei and nuclear apoptotic bodies in DAPI-stained cells exposed to nanoparticles showed an increase in apoptotic cells. Flow cytometry analysis demonstrated a lower red-to-green ratio in SH-SY-5Y cells treated with nanoparticles. This suggests improved mitochondrial health, cellular viability restoration, and prevention of the apoptotic process. This study provides essential data on the synthesis and potential of MSNs loaded with BBR, which may serve as a viable therapeutic intervention for conditions associated with apoptosis.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d3na01142a
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Article ; Online: Quality of Life Assessment in Diabetic Patients Using a Validated Tool in a Patient Population Visiting a Tertiary Care Center in Bhubaneswar, Odisha, India.

Meher, Dayanidhi / Kar, Sonali / Pathak, Mona / Singh, Snigdha

TheScientificWorldJournal

2020 Volume 2020, Page(s) 7571838

Abstract: Odisha has 4.2 million diabetic patients against the country's 70 million with an urban prevalence of nearly 15.4%. Diabetes is affecting younger age groups, thus having a crucial impact on quality of life of the affected. A qualitative endeavour was ... ...

Abstract	Odisha has 4.2 million diabetic patients against the country's 70 million with an urban prevalence of nearly 15.4%. Diabetes is affecting younger age groups, thus having a crucial impact on quality of life of the affected. A qualitative endeavour was attempted at the diabetic clinic of a tertiary care set up in the capital city of Bhubaneswar to create a diabetic surveillance data assembly, wherein subjects above 18 years of age and newly diagnosed or on follow-up, after obtaining informed consent, were made to respond to a quality of life (QOLID) validated tool. The pretested tool has 8-domain role limitation due to physical health, physical endurance, general health, treatment satisfaction, symptom botherness, financial worries, emotional/mental health, and diet advice tolerance. The validated tool had 34 items (questions) that were selected to represent these domains on the basis of extraction communality, factor loading, and interitem and item-total correlations. The final questionnaire had an overall Cronbach's alpha value of 0.894 (subscale: 0.55 to 0.85), showing high internal consistency in the current study population. A score for each domain was calculated by simple addition of items scores. Each individual domain score was then standardized by dividing by maximum possible domain score and multiplying by 100. All individual standardized domain scores were then added and divided by 8 (number of domain) to obtain an overall score. The data collection was done for 400 patients as an interim analysis. Univariate and subsequently multivariate analysis was performed to decide the predictors that affected quality of life. Age over 50 years (OR = 1.81, CI 1.12-2.93;
MeSH term(s)	Adult ; Aged ; Ambulatory Care ; Diabetes Mellitus/epidemiology ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Odds Ratio ; Public Health Surveillance ; Quality of Life ; Tertiary Care Centers
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075968-X
ISSN	1537-744X ; 1537-744X
ISSN (online)	1537-744X
ISSN	1537-744X
DOI	10.1155/2020/7571838
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