Article: Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death.
Frontiers in molecular neuroscience
2022 Volume 15, Page(s) 888420
Abstract: Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation. However, the mechanism underlying the nuclear import of tau is unclear, as is the contribution of ... ...
Abstract | Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation. However, the mechanism underlying the nuclear import of tau is unclear, as is the contribution of nuclear tau to the pathology of tauopathies. We have previously generated a pathological form of tau, PH-tau (pseudophosphorylation mutants S199E, T212E, T231E, and S262E) that mimics AD pathological behavior in cells, |
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Language | English |
Publishing date | 2022-05-03 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2452967-9 |
ISSN | 1662-5099 |
ISSN | 1662-5099 |
DOI | 10.3389/fnmol.2022.888420 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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