Article ; Online: p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Mutation research. Genetic toxicology and environmental mutagenesis
2018 Volume 829-830, Page(s) 70–74
Abstract: Lung cancer mortality in Xuan Wei County (XWC) is among the highest in China. Lung cancer in XWC is ...
Abstract | Lung cancer mortality in Xuan Wei County (XWC) is among the highest in China. Lung cancer in XWC is associated with exposure, in poorly vented homes, to coal smoke containing high levels of polycyclic aromatic hydrocarbons (PAHs). We have previously investigated mutations in the p53 tumor suppressor gene and the K-ras oncogene in lung carcinomas and in sputum samples from individuals exposed to smoky coal emissions in XWC. This paper summarizes the results concerning p53 and K-ras mutations from these studies, in relation to mutations found in lung cancer patients not exposed to smoky coal emissions. |
---|---|
MeSH term(s) | Coal/toxicity ; Female ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/genetics ; Male ; Point Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Sex Factors ; Smoking/adverse effects ; Sputum/chemistry ; Sputum/drug effects ; Tumor Suppressor Protein p53/genetics |
Chemical Substances | Coal ; KRAS protein, human ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) |
Language | English |
Publishing date | 2018-03-30 |
Publishing country | Netherlands |
Document type | Journal Article |
ISSN | 1879-3592 |
ISSN (online) | 1879-3592 |
DOI | 10.1016/j.mrgentox.2018.03.010 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.