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  1. Article ; Online: Evaluation of SARS CoV-2 RT-PCR in a multiple sample pool

    Jaya Garg / Atul Garg

    Indian Journal of Medical Research, Vol 153, Iss 5, Pp 699-

    2021  Volume 700

    Keywords Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Evaluation of SARS CoV-2 RT-PCR in a multiple sample pool.

    Garg, Jaya / Garg, Atul

    The Indian journal of medical research

    2021  Volume 153, Issue 5&6, Page(s) 699–700

    MeSH term(s) COVID-19 ; Humans ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/genetics ; Specimen Handling
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-06-18
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_4282_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Elucidating the Structural Features of ABCA1 in its Heterogeneous Membrane Environment.

    Sunidhi, S / Sacher, Sukriti / Atul / Garg, Parth / Ray, Arjun

    Frontiers in molecular biosciences

    2022  Volume 8, Page(s) 803078

    Abstract: ATP Binding Cassette Transporter A1 (ABCA1) plays an integral part in Reverse Cholesterol Transport (RCT) and is critical for maintaining lipid homeostasis. One theory of lipid efflux by the transporter (alternating access) proposes that ABCA1 harbours ... ...

    Abstract ATP Binding Cassette Transporter A1 (ABCA1) plays an integral part in Reverse Cholesterol Transport (RCT) and is critical for maintaining lipid homeostasis. One theory of lipid efflux by the transporter (alternating access) proposes that ABCA1 harbours two different conformations that provide alternating access for lipid binding and release. This is followed by sequestration
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.803078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of Coronavirus Disease 2019 (COVID-19) RT-qPCR Tests in Multi-sample Pools.

    Garg, Atul / Garg, Jaya

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 9, Page(s) e434

    MeSH term(s) COVID-19 ; Humans ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1099
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  5. Article ; Online: Regulatory, safety and economic considerations of over-the-counter medicines in the Indian population.

    Narang, Prashant / Garg, Vandana / Sharma, Atul

    Discover health systems

    2023  Volume 2, Issue 1, Page(s) 17

    Abstract: Background and purpose of review: Over-the-counter (OTC) medication has been an integral component of an established health care system but their easy accessibility might pose significant risks. This review has attempted to highlight the present ... ...

    Abstract Background and purpose of review: Over-the-counter (OTC) medication has been an integral component of an established health care system but their easy accessibility might pose significant risks. This review has attempted to highlight the present scenario of OTC utilization in India, regarding standard practices followed globally. An attempt has also been made to highlight the lifecycle of a prescription and OTC medicine and the benefits and regulatory process involved in the prescription-to-OTC switch.
    Findings: A paradigm shift has been observed in self-medication practice with OTC medicines in recent times and has become a widespread practice worldwide. Numerous key drivers, such as increasing consumer awareness, broader consumer access to essential medication, and socio-economic benefits to the public health care system, have advocated this practice. On the other hand, self-medication using OTC is also inextricably linked with inevitable risks such as excessive drug dosage, polypharmacy, drug abuse, and drug interactions. Nevertheless, these issues could be further regulated by employing a defined OTC framework. The government of India has recognized the utmost need to develop a robust policy framework for the effective utilization of OTC drugs. Also, various initiatives toward modifying existing laws or developing new OTC drug policies has been taken.
    Conclusion: Prioritizing the utmost safety of the consumers and evident need of strong regulatory framework with respect to OTC drugs, the term "OTC" has been recommended as a distinct category of drugs by Government of India. This review has highlighted various factors that can play an essential role in OTC utilization and can be considered during policy reformation.
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2731-7501
    ISSN (online) 2731-7501
    DOI 10.1007/s44250-023-00032-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pyrexia in lupus: cryptococcal fungaemia - an unusual aetiology.

    Atul, Kakar / Garg, Gunjan / Gogia, Atul

    Tropical doctor

    2016  Volume 46, Issue 4, Page(s) 239–241

    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/0049475515621652
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  7. Article ; Online: Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephalitis infected BV2 and neuro 2A cell lines associated with worst outcome.

    Shukla, Mukti / Garg, Atul / Dhole, T N / Chaturvedi, Rachna

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 16

    Abstract: Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in ... ...

    Abstract Japanese encephalitis (JE) disease, a viral brain fever is caused by Japanese encephalitis virus (JEV). Despite the availability of effective vaccines against this deadly infection, JE is the leading cause of epidemic viral encephalitis in children in South-east Asia. There is no treatment available for the JE disease which might be due to incomplete understanding of the pathogenesis of JE virus. The JEV infections lead to permanent neurological deficits even in those who survive from the infection. Activated microglia may play a potentially detrimental role by eliciting the expression of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) influencing the surrounding brain tissue. Microglial activation, proinflammatory cytokine release and leukocytes trafficking are associated following JEV infection in central nervous system (CNS). How the pattern recognition receptors sense the viral nucleic acid and how the microglial and neuronal cells behaves following JEV infection is still unelucidated. There is scarcity of data on the expression levels of toll like receptors (TLRs), cytokines and chemokines in JEV infection in invitro model. To explore the molecular mechanisms of JEV infection of microglial cells and neuronal cells, we studied the expression profile of TLRs, cytokines and chemokines in JEV infected microglial cell line BV2 and Neuronal cell line Neuro 2A. For the present study, we developed the mouse model of encephalitis by intracerebral (IC) injection of JE virus for virus propagation, disease progression and damage study. Our results demonstrate the exaggerated release of some specific TLRs, cytokines and chemokines in invitro cell culture of microglial and Neuro 2A cell line, which are associated with bad outcome in invivo study.
    MeSH term(s) Mice ; Animals ; Encephalitis, Japanese ; Cytokines/metabolism ; Chemokines ; Encephalitis Virus, Japanese ; Cell Line ; Toll-Like Receptors
    Chemical Substances Cytokines ; Chemokines ; Toll-Like Receptors
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-01966-8
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  8. Article ; Online: Evaluation of Coronavirus Disease 2019 (COVID-19) RT-qPCR Tests in Multi-sample Pools

    Garg, Atul / Garg, Jaya

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1099
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Circulating MicroRNA-29a

    Jaya Garg / Atul Garg / Anand kumar

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 3, Pp DC19-DC

    An Evolving Biomarker for Diagnosis of Pulmonary Tuberculosis

    2021  Volume 23

    Abstract: Introduction: Tuberculosis (TB) is global health problem threatening millions every year. There is urgent need of effective biomarkers for its diagnostics and circulating microRNAs (miRNAs) have recently emerged as novel and non-invasive molecular ... ...

    Abstract Introduction: Tuberculosis (TB) is global health problem threatening millions every year. There is urgent need of effective biomarkers for its diagnostics and circulating microRNAs (miRNAs) have recently emerged as novel and non-invasive molecular markers in blood. Aim: To evaluate serum miRNAs as a potential biomarker for the diagnosis of pulmonary mycobacterium tuberculosis infection. Materials and Methods: In this prospective cross-sectional study, acute pulmonary TB patients were recruited based on positive Mycobacterium tuberculosis Polymerase Chain Reaction (PCR) in sputum samples and Microarray expression profiling was performed on blood of these patients to study differentially expressed miRNAs. The results were validated by Real-Time Polymerase Chain Reaction (RT-PCR) on pulmonary TB cases and healthy controls. Student’s t-tests and Analysis of Variance (ANOVA) tests were used for statistical analysis. The p-value <0.05 was considered statistically significant. Results: Results of microarray expression profiling showed 75 differentially expressed miRNAs in cases of pulmonary TB; among these 5 upregulated and 2 downregulated miRNAs were evaluated by RT-PCR. miRNA 29a exhibited good distinguishing efficiency; followed by miRNA 384. Receiver Operating Characteristic (ROC) curve of expression data for miRNA in cases and control groups showed that Area Under the Curve (AUC) of miRNA-29a was 0.8268 (sensitivity=80%, specificity=82%). Conclusion: This study suggests that altered levels of serum miRNAs have great potential to serve as non-invasive biomarkers for detection of Mycobacterium tuberculosis infection. MicroRNA29a can be used as an effective biomarker for diagnosis of pulmonary TB.
    Keywords mycobacterium tuberculosis ; real-time polymerase chain reaction ; taqman microarray ; Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer.

    Macadangdang, Romulo R / Agrawal, Rutvi / Bhushan, Bharat / Garg, Akash / Singh, Kuldeep / Kumar, Shivendra / Kumar, Atul

    Current pharmaceutical biotechnology

    2024  

    Abstract: Cancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising ... ...

    Abstract Cancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising avenue in cancer treatment, offering novel strategies for targeted drug delivery. Nanoparticles, liposomes, and polymer-based systems have played pivotal roles in revolutionizing cancer therapy. Nanotechnology possesses unique physicochemical properties, enabling efficient encapsulation of therapeutic agents and controlled and prolonged release at tumour sites. Advancement in formulations using nanotechnology has made it possible to make multifunctional systems that respond to the microenvironment of a tumour by releasing payloads in response to changes in pH, temperature, or enzymes. Stimuli-responsive polymers can release drugs in response to external cues, enabling site-specific drug release and minimizing systemic exposure. This review explores recent studies and preclinical trials that show how nanoparticles, liposomes, and polymerbased systems could be used to treat cancer, discussing challenges such as scalability, regulatory approval, and potential toxicity concerns along with patents published recently.
    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010279483240417050548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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