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  1. Artikel ; Online: Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study.

    Han, Deheng / Yu, Fangcong / Zheng, Liangrong

    Epidemiology and health

    2024  , Seite(n) e2024046

    Abstract: Objectives: Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to ... ...

    Abstract Objectives: Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to explore the causal relationship between serum MMP levels and VTE by using the Mendelian randomization (MR) method.
    Methods: In this study 2-sample MR study, the exposure data on serum MMP levels were derived from genome-wide association studies involving 21,758 individuals from 13 cohorts of European descent. The outcome data on VTE, including deep vein thrombosis and pulmonary embolism, were derived from the FinnGen research project. The primary method used was the inverse-variance weighting method. The MR-Egger intercept test and the Cochran Q test were used to evaluate pleiotropy and heterogeneity.
    Results: Using the inverse-variance weighting method, higher serum MMP-12 levels were found to be associated with an increased risk of VTE (odds ratio, 1.04; 95% confidence interval, 1.01-1.07; p=0.0015). Moreover, there was a weak association between the levels of certain MMPs and VTE. Sensitivity analyses revealed no significant heterogeneity and pleiotropy in our study, and the Steiger directionality test did not reveal a significant reverse causation association.
    Conclusion: : There is a causal association between MMP-12 levels and VTE, which may have substantial implications for the diagnostic and therapeutic strategies used for VTE.
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2590698-7
    ISSN 2092-7193 ; 2092-7193
    ISSN (online) 2092-7193
    ISSN 2092-7193
    DOI 10.4178/epih.e2024046
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  2. Buch ; Online: Accessible Robot Control in Mixed Reality

    Zhang, Ganlin / Zhang, Deheng / Duan, Longteng / Han, Guo

    2023  

    Abstract: A novel method to control the Spot robot of Boston Dynamics by Hololens 2 is proposed. This method is mainly designed for people with physical disabilities, users can control the robot's movement and robot arm without using their hands. The eye gaze ... ...

    Abstract A novel method to control the Spot robot of Boston Dynamics by Hololens 2 is proposed. This method is mainly designed for people with physical disabilities, users can control the robot's movement and robot arm without using their hands. The eye gaze tracking and head motion tracking technologies of Hololens 2 are utilized for sending control commands. The movement of the robot would follow the eye gaze and the robot arm would mimic the pose of the user's head. Through our experiment, our method is comparable with the traditional control method by joystick in both time efficiency and user experience. Demo can be found on our project webpage: https://zhangganlin.github.io/Holo-Spot-Page/index.html

    Comment: Course Project of Mixed Reality at ETH Zurich
    Schlagwörter Computer Science - Robotics ; Computer Science - Computer Vision and Pattern Recognition
    Erscheinungsdatum 2023-06-04
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    Dokumenttyp Buch ; Online
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  3. Buch ; Online: Lossy Computing with Side Information via Multi-Hypergraphs

    Yuan, Deheng / Guo, Tao / Bai, Bo / Han, Wei

    2022  

    Abstract: We consider a problem of coding for computing, where the decoder wishes to estimate a function of its local message and the source message at the encoder within a given distortion. We show that the rate-distortion function can be characterized through a ... ...

    Abstract We consider a problem of coding for computing, where the decoder wishes to estimate a function of its local message and the source message at the encoder within a given distortion. We show that the rate-distortion function can be characterized through a characteristic multi-hypergraph, which simplifies the evaluation of the rate-distortion function.
    Schlagwörter Computer Science - Information Theory
    Erscheinungsdatum 2022-05-17
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    Dokumenttyp Buch ; Online
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  4. Artikel ; Online: SARS-CoV-2 was found in the bile juice from a patient with severe COVID-19.

    Han, Deheng / Fang, Qiang / Wang, Xingxiang

    Journal of medical virology

    2020  Band 93, Heft 1, Seite(n) 102–104

    Mesh-Begriff(e) Bile/virology ; COVID-19/pathology ; COVID-19/virology ; Cholangiopancreatography, Endoscopic Retrograde ; Cholestasis/pathology ; Cholestasis/surgery ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-29
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26169
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  5. Artikel ; Online: Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway.

    Chen, Lu / Sun, Xingang / Wang, Zhen / Chen, Miao / He, Yuxian / Zhang, Han / Han, Deheng / Zheng, Liangrong

    Toxicology and applied pharmacology

    2023  Band 482, Seite(n) 116794

    Abstract: Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective ... ...

    Abstract Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) is a natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective effect of Res on Dox-induced cardiotoxicity (DIC) and explore whether it was related to attenuating ferroptosis. We established DIC models in C57BL/6 J mice, H9C2 cardiomyoblasts, and neonatal rat cardiomyocytes (NRCMs). We further treated H9C2 cells with RSL3, a ferroptosis agonist, to investigate whether Res exerted protective effects through inhibiting ferroptosis. Ferrostatin-1 (Fer-1) was applied to suppress ferroptosis. Dox treatment caused cardiac dysfunction and resulted in apparent ferroptotic damage in cardiac tissue, involving increased iron accumulation, glutathione depletion, increased expression of ferroptosis-related proteins, and decreased expression of glutathione peroxidase 4, which were alleviated by Fer-1 and Res administration. These findings were also confirmed in Dox-treated H9C2 cells and NRCMs, with Fer-1 and Res effectively attenuating Dox-induced cytotoxicity and ferroptosis. Furthermore, Res protected H9C2 cells from RSL3-induced ferroptotic cell death, and the protective effect was similar to that of Fer-1. Both Dox and RSL3 treatment increased the phosphorylation levels of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinases; however, these changes were hindered by Res. This study demonstrates that Res effectively alleviates DIC by suppressing ferroptosis possibly through modulating the MAPK signaling pathway. Our results highlight that targeting ferroptosis can be a potential cardioprotective strategy for DIC.
    Mesh-Begriff(e) Mice ; Rats ; Animals ; Resveratrol/pharmacology ; Cardiotoxicity/pathology ; Ferroptosis ; Apoptosis ; Cell Line ; Mice, Inbred C57BL ; Signal Transduction ; Doxorubicin/pharmacology ; Myocytes, Cardiac ; Oxidative Stress
    Chemische Substanzen Resveratrol (Q369O8926L) ; Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2023-12-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116794
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  6. Artikel ; Online: Determinants of left atrial thrombus or spontaneous echo contrast in nonvalvular atrial fibrillation.

    Han, Deheng / Chu, Yanan / Wu, Yakui / Wang, Xingxiang

    Thrombosis research

    2020  Band 195, Seite(n) 233–237

    Abstract: Background: The CHADS: Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The ... ...

    Abstract Background: The CHADS
    Methods: We identified 1102 consecutive AF patients who underwent transesophageal echocardiography (TEE) for the purpose of the exclusion of LAT before catheter ablation, cardioversion or left atrial appendage occlusion. The clinical, echocardiographic and laboratory characteristics of patients were collected from the electronic medical record system.
    Results: In the study, the prevalence of LAT/SEC was only 4.36%. In the multivariate logistic analysis, hypertension, left atrial enlargement, prior stroke/TIA, left ventricular dysfunction, and renal dysfunction were predictors of LAT/SEC. Receiver operating characteristic curve analysis showed that c-statistics of the CHADS
    Conclusion: In our cohort, we found two variables not included in the CHA
    Mesh-Begriff(e) Atrial Fibrillation/complications ; Humans ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Thrombosis
    Sprache Englisch
    Erscheinungsdatum 2020-08-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.07.055
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  7. Artikel ; Online: Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study.

    Chen, Lu / Sun, Xingang / Han, Deheng / Zhong, Jiawei / Zhang, Han / Zheng, Liangrong

    Frontiers in public health

    2022  Band 10, Seite(n) 1023935

    Abstract: Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is ... ...

    Abstract Background: Coronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospitalization, or severity of COVID-19 remains unconfirmed. We aimed to investigate the causal associations between VAT and susceptibility, hospitalization, and severity of COVID-19.
    Methods: We applied a two-sample Mendelian randomization (MR) study to infer causal associations between VAT and COVID-19 outcomes. Single-nucleotide polymorphisms significantly associated with VAT were derived from a large-scale genome-wide association study. The random-effects inverse-variance weighted method was used as the main MR approach, complemented by three other MR methods. Additional sensitivity analyses were also performed.
    Results: Genetically predicted higher VAT mass was causally associated with higher risks of COVID-19 susceptibility [odds ratios (ORs) = 1.13; 95% confidence interval (CI), 1.09-1.17;
    Conclusion: This study provided genetic evidence that higher VAT mass was causally associated with higher risks of susceptibility, hospitalization, and severity of COVID-19. VAT can be a useful tool for risk assessment in the general population and COVID-19 patients, as well as an important prevention target.
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; Intra-Abdominal Fat ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Hospitalization
    Sprache Englisch
    Erscheinungsdatum 2022-10-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1023935
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  8. Buch ; Online: RLTF

    Liu, Jiate / Zhu, Yiqin / Xiao, Kaiwen / Fu, Qiang / Han, Xiao / Yang, Wei / Ye, Deheng

    Reinforcement Learning from Unit Test Feedback

    2023  

    Abstract: The goal of program synthesis, or code generation, is to generate executable code based on given descriptions. Recently, there has been an increasing number of studies employing reinforcement learning (RL) to improve the performance of large language ... ...

    Abstract The goal of program synthesis, or code generation, is to generate executable code based on given descriptions. Recently, there has been an increasing number of studies employing reinforcement learning (RL) to improve the performance of large language models (LLMs) for code. However, current representative works either rely solely on offline frameworks, limiting the exploration of new sample spaces, or fall short in the utilization of unit test signals, not accounting for specific error locations within the code. To address these issues, we propose RLTF, i.e., Reinforcement Learning from Unit Test Feedback, a novel online RL framework with unit test feedback of multi-granularity for refining code LLMs. Our approach generates data in real-time during training and simultaneously utilizes fine-grained feedback signals to guide the model towards producing higher-quality code. Extensive experiments show that RLTF achieves state-of-the-art performance on the APPS and the MBPP benchmarks. Our code is available at: https://github.com/Zyq-scut/RLTF.

    Comment: Accepted by TMLR
    Schlagwörter Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Machine Learning
    Thema/Rubrik (Code) 004
    Erscheinungsdatum 2023-07-10
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  9. Artikel ; Online: SARS‐CoV‐2 was found in the bile juice from a patient with severe COVID‐19

    Han, Deheng / Fang, Qiang / Wang, Xingxiang

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Schlagwörter Virology ; Infectious Diseases ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1002/jmv.26169
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  10. Artikel ; Online: A randomized clinical trial for meal bolus decision using learning-based control in adults with type 2 diabetes.

    Liu, Wei / Cai, Deheng / Zhang, Rui / Zhang, Xiuying / Cai, Xiaoling / Tao, Liyuan / Han, Xueyao / Luo, Yingying / Li, Meng / Wu, Wenjing / Ma, Yumin / Shi, Dawei / Ji, Linong

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Background: We proposed an artificial-pancreas-like algorithm (AP-A) which could automatically determine the pre-prandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple dose injection ( ... ...

    Abstract Background: We proposed an artificial-pancreas-like algorithm (AP-A) which could automatically determine the pre-prandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple dose injection (MDI) therapy. We aim to determine whether pre-prandial insulin dose adjustments guided by the AP-A is as effective and safe as physician decisions.
    Methods: We performed a randomized, single-blind, clinical trial at a tertiary, referral hospital in Beijing, China. Type 2 diabetes participants were eligible if they were aged  18 years, with a glycated hemoglobin of 8.0% or higher. Eligible participants were randomly assigned (1:1) to the AP-A arm supervised by physician and the conventional physician treatment arm. The primary objective was to compare percentage time spent with sensor glucose level in 3.9-10.0 mmol/L (TIR) between the two study arms. Safety was assessed by the percentage time spent with sensor glucose level below 3.0 mmol/L (TBR).
    Results: 140 participants were screened, of whom 119 were randomly assigned to AP-A arm (n = 59) or physician arm (n = 60). The TIR achieved by the AP-A arm was statistically non-inferior compared with the control arm (72.4% (63.3-82.1) vs. 71.2% (54.9-81.4)), with a median difference of 1.33% (95% CI, -6.00 to 10.94, non-inferiority margin -7.5%). TBR was also statistically non-inferior between the AP-A and control arms (0.0% (0.0-0.0) vs. 0.0% (0.0-0.0), respectively; median difference (95% CI, 0.00% (0.00 to 0.00), non-inferiority margin 2.0%).
    Conclusions: The AP-A supported physician titration of pre-prandial insulin dosage offers non-inferior glycemic control compared with optimal physician care in type 2 diabetes.
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae143
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