Treffer 1 - 10 von insgesamt 2225
The Dental register
2021 Band 48, Heft 6, Seite(n) 309–310
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2021-03-10 |
| Erscheinungsland | United States |
| Dokumenttyp | Editorial |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2021
| Schlagwörter | bic Book Industry Communication ; oceanography, climate change, reefs, marine science, marine conservation, marine research |
|---|---|
| Umfang | 1 electronic resource (143 pages) |
| Verlag | Taylor and Francis |
| Dokumenttyp | Buch ; Online |
| Anmerkung | English[eng] ; Open Access |
| HBZ-ID | HT021291011 |
| ISBN | 9780367685225 ; 0367685221 |
| Datenquelle | ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar |
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Urology practice
2024 Band 11, Heft 2, Seite(n) 276–282
Abstract: Introduction: Mark Cuban Cost Plus Drug Company (MCCPDC) launched in 2022 with a goal to decrease prescription drug costs. Thus far, research has focused on possible savings if Medicare purchased its annual volume of drugs at MCCPDC prices. The aim of ... ...
| Abstract | Introduction: Mark Cuban Cost Plus Drug Company (MCCPDC) launched in 2022 with a goal to decrease prescription drug costs. Thus far, research has focused on possible savings if Medicare purchased its annual volume of drugs at MCCPDC prices. The aim of this study is to analyze if MCCPDC can offer savings directly to urologic patients compared with other mail-order pharmacies, local pharmacies, and with patients using health insurance. Methods: Twelve drugs used to treat urological diseases available on MCCPDC were analyzed. Pricing data of 30-tab and 90-tab prescriptions from MCCPDC, other mail-order pharmacies, and local in-person pharmacies near our zip code 40508 (Lexington, Kentucky) were compiled. To compare if MCCPDC could offer savings to patients using health insurance to fill their prescriptions, out-of-pocket drug costs for patients from the 2020 and 2021 Medical Expenditure Panel Survey and the 2021 Medicare Part D spending data were extracted. Results: Greater savings at MCCPDC were found at 90-tab prescriptions, but overall variability in prices existed. When comparing without health insurance, 9 of 12 drugs at MCCPDC were cheaper at 90 tabs with solifenacin and tadalafil saving $20 and $12 per prescription. When considering patients using insurance, abiraterone, sildenafil, and tadalafil offered savings on out-of-pocket costs at 30- and 90-tab prescriptions. Conclusions: MCCPDC may offer cheaper prices for patients filling urologic medications, especially at 90-tab prescriptions. This study is the first to show patients could save money using MCCPDC and has implications for physician counseling when prescribing common urologic drugs. |
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| Mesh-Begriff(e) | Aged ; Humans ; United States ; Prescription Drugs ; Drug Costs ; Tadalafil ; Medicare Part D ; Insurance, Health |
| Chemische Substanzen | Prescription Drugs ; Tadalafil (742SXX0ICT) |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-02-20 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ISSN | 2352-0787 |
| ISSN (online) | 2352-0787 |
| DOI | 10.1097/UPJ.0000000000000510 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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Pigment cell & melanoma research
2024
Abstract: Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells ... ...
| Abstract | Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, Cdh3+/-) and identified novel qMcSC subpopulations, including two that differentially regulate their immune privilege status. Within qMcSC subpopulations, we also predicted melanocyte differentiation potential, neural crest potential, and quiescence depth. Taken together, the results demonstrate that the qMcSC population is heterogeneous and future studies focused on investigating changes in qMcSCs should consider changes in subpopulation composition. |
|---|---|
| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-13 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2409570-9 |
| ISSN | 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471 |
| ISSN (online) | 1755-148X ; 1600-0749 |
| ISSN | 0893-5785 ; 1755-1471 |
| DOI | 10.1111/pcmr.13169 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2444: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 Band 13, Heft 5
Abstract: Connexins (Cxs) are a family of integral membrane proteins, which function as both hexameric hemichannels (HCs) and dodecameric gap junction channels (GJCs), behaving as conduits for the electrical and molecular communication between cells and between ... ...
| Abstract | Connexins (Cxs) are a family of integral membrane proteins, which function as both hexameric hemichannels (HCs) and dodecameric gap junction channels (GJCs), behaving as conduits for the electrical and molecular communication between cells and between cells and the extracellular environment, respectively. Their proper functioning is crucial for many processes, including development, physiology, and response to disease and trauma. Abnormal GJC and HC communication can lead to numerous pathological states including inflammation, skin diseases, deafness, nervous system disorders, and cardiac arrhythmias. Over the last 15 years, high-resolution X-ray and electron cryomicroscopy (cryoEM) structures for seven Cx isoforms have revealed conservation in the four-helix transmembrane (TM) bundle of each subunit; an αβ fold in the disulfide-bonded extracellular loops and inter-subunit hydrogen bonding across the extracellular gap that mediates end-to-end docking to form a tight seal between hexamers in the GJC. Tissue injury is associated with cellular Ca |
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| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-26 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 2661517-4 |
| ISSN | 2079-7737 |
| ISSN | 2079-7737 |
| DOI | 10.3390/biology13050298 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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The Journal of general physiology
2018 Band 150, Heft 12, Seite(n) 1606–1639
Abstract: As the physiology of synapses began to be explored in the 1950s, it became clear that electrical communication between neurons could not always be explained by chemical transmission. Instead, careful studies pointed to a direct intercellular pathway of ... ...
| Abstract | As the physiology of synapses began to be explored in the 1950s, it became clear that electrical communication between neurons could not always be explained by chemical transmission. Instead, careful studies pointed to a direct intercellular pathway of current flow and to the anatomical structure that was (eventually) called the gap junction. The mechanism of intercellular current flow was simple compared with chemical transmission, but the consequences of electrical signaling in excitable tissues were not. With the recognition that channels were a means of passive ion movement across membranes, the character and behavior of gap junction channels came under scrutiny. It became evident that these gated channels mediated intercellular transfer of small molecules as well as atomic ions, thereby mediating chemical, as well as electrical, signaling. Members of the responsible protein family in vertebrates-connexins-were cloned and their channels studied by many of the increasingly biophysical techniques that were being applied to other channels. As described here, much of the evolution of the field, from electrical coupling to channel structure-function, has appeared in the pages of the |
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| Mesh-Begriff(e) | Action Potentials ; Animals ; Connexins/physiology ; Electrophysiology/history ; Gap Junctions/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Synapses/physiology |
| Chemische Substanzen | Connexins |
| Sprache | Englisch |
| Erscheinungsdatum | 2018-11-02 |
| Erscheinungsland | United States |
| Dokumenttyp | Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ZDB-ID | 3118-5 |
| ISSN | 1540-7748 ; 0022-1295 |
| ISSN (online) | 1540-7748 |
| ISSN | 0022-1295 |
| DOI | 10.1085/jgp.201812203 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.150: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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bioRxiv : the preprint server for biology
2023
Abstract: Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45-cells ... ...
| Abstract | Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45-cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Significance: Single cell transcriptomics has revolutionized our ability to interrogate the dynamic nature of tissues. Here we provide a high-resolution map of the melanocyte stem cell population during quiescence. This map provides one of few examples highlighting broad heterogeneity in stem cells during the quiescent cell state. The map also unifies previous observations using other cell, molecular and functional analyses to define the unique features of the quiescent melanocyte stem cell population. This data provides a valuable resource to individuals interested in further evaluating aspects of cellular quiescence in stem cells broadly or melanocyte stem cells specifically. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2023-12-20 |
| Erscheinungsland | United States |
| Dokumenttyp | Preprint |
| DOI | 10.1101/2023.12.19.571712 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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Quality management in health care
2023 Band 32, Heft 3, Seite(n) 213–215
| Mesh-Begriff(e) | Humans ; Pain ; Evidence-Based Practice ; Guideline Adherence |
|---|---|
| Sprache | Englisch |
| Erscheinungsdatum | 2023-06-21 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1162319-6 |
| ISSN | 1550-5154 ; 1063-8628 |
| ISSN (online) | 1550-5154 |
| ISSN | 1063-8628 |
| DOI | 10.1097/QMH.0000000000000430 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3806: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Molecular biology and evolution
2022
Abstract: Tree House Explorer (THEx) is a genome browser that integrates phylogenomic data and genomic annotations into a single interactive platform for combined analysis. THEx allows users to visualize genome-wide variation in evolutionary histories and genetic ... ...
| Abstract | Tree House Explorer (THEx) is a genome browser that integrates phylogenomic data and genomic annotations into a single interactive platform for combined analysis. THEx allows users to visualize genome-wide variation in evolutionary histories and genetic divergence on a chromosome-by-chromosome basis, with continuous sliding window comparisons to gene annotations (GFF/GTF), recombination rates, and other user-specified, highly customizable feature annotations. THEx provides a new platform for interactive phylogenomic data visualization to analyze and interpret the diverse evolutionary histories woven throughout genomes. Hosted on Conda, THEx integrates seamlessly into new or pre-existing workflows. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-06-14 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 998579-7 |
| ISSN | 1537-1719 ; 0737-4038 |
| ISSN (online) | 1537-1719 |
| ISSN | 0737-4038 |
| DOI | 10.1093/molbev/msac130 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2137: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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JAMA network open
2024 Band 7, Heft 3, Seite(n) e243821
Abstract: Importance: Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity.: Objective: To use activity, ... ...
| Abstract | Importance: Despite consistent public health recommendations, obesity rates in the US continue to increase. Physical activity recommendations do not account for individual genetic variability, increasing risk of obesity. Objective: To use activity, clinical, and genetic data from the All of Us Research Program (AoURP) to explore the association of genetic risk of higher body mass index (BMI) with the level of physical activity needed to reduce incident obesity. Design, setting, and participants: In this US population-based retrospective cohort study, participants were enrolled in the AoURP between May 1, 2018, and July 1, 2022. Enrollees in the AoURP who were of European ancestry, owned a personal activity tracking device, and did not have obesity up to 6 months into activity tracking were included in the analysis. Exposure: Physical activity expressed as daily step counts and a polygenic risk score (PRS) for BMI, calculated as weight in kilograms divided by height in meters squared. Main outcome and measures: Incident obesity (BMI ≥30). Results: A total of 3124 participants met inclusion criteria. Among 3051 participants with available data, 2216 (73%) were women, and the median age was 52.7 (IQR, 36.4-62.8) years. The total cohort of 3124 participants walked a median of 8326 (IQR, 6499-10 389) steps/d over a median of 5.4 (IQR, 3.4-7.0) years of personal activity tracking. The incidence of obesity over the study period increased from 13% (101 of 781) to 43% (335 of 781) in the lowest and highest PRS quartiles, respectively (P = 1.0 × 10-20). The BMI PRS demonstrated an 81% increase in obesity risk (P = 3.57 × 10-20) while mean step count demonstrated a 43% reduction (P = 5.30 × 10-12) when comparing the 75th and 25th percentiles, respectively. Individuals with a PRS in the 75th percentile would need to walk a mean of 2280 (95% CI, 1680-3310) more steps per day (11 020 total) than those at the 50th percentile to have a comparable risk of obesity. To have a comparable risk of obesity to individuals at the 25th percentile of PRS, those at the 75th percentile with a baseline BMI of 22 would need to walk an additional 3460 steps/d; with a baseline BMI of 24, an additional 4430 steps/d; with a baseline BMI of 26, an additional 5380 steps/d; and with a baseline BMI of 28, an additional 6350 steps/d. Conclusions and relevance: In this cohort study, the association between daily step count and obesity risk across genetic background and baseline BMI were quantified. Population-based recommendations may underestimate physical activity needed to prevent obesity among those at high genetic risk. |
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| Mesh-Begriff(e) | Female ; Humans ; Middle Aged ; Male ; Cohort Studies ; Retrospective Studies ; Population Health ; Obesity ; Exercise ; Genetic Risk Score |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-03-04 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ISSN | 2574-3805 |
| ISSN (online) | 2574-3805 |
| DOI | 10.1001/jamanetworkopen.2024.3821 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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