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Thesis ; Online: Adult Hippocampal Neurogenesis in the Context of Taxonomy, Hippocampal Network, Domestication and Amyloid Precursor Protein

Huang, Shih-Hui

2019

Keywords	info:eu-repo/classification/ddc/590 ; info:eu-repo/classification/ddc/610 ; Zoological sciences ; Medical sciences ; medicine
Language	English
Publisher	ETH Zurich
Publishing country	ch
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Various facets of vertebrate cilia: motility, signaling, and role in adult neurogenesis.

Huang, Shihhui / Hirota, Yuki / Sawamoto, Kazunobu

Proceedings of the Japan Academy. Series B, Physical and biological sciences

2009 Volume 85, Issue 8, Page(s) 324–336

Abstract: Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, ...

Abstract	Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.
MeSH term(s)	Animals ; Cilia/metabolism ; Humans ; Movement ; Neurogenesis ; Signal Transduction ; Vertebrates/physiology
Language	English
Publishing date	2009-10-17
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	161781-3
ISSN	1349-2896 ; 0386-2208
ISSN (online)	1349-2896
ISSN	0386-2208
DOI	10.2183/pjab.85.324
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Article: Blumea chishangensis sp. nov. (Asteraceae: Inuleae) from Taiwan and new insights into the phylogeny of Blumea.

Chung, Shih-Wen / Huang, Wei-Jie / Chen, Zhi-Hao / Liu, Shih-Hui

Botanical studies

2022 Volume 63, Issue 1, Page(s) 21

Abstract: ... insubstantial. Here, a new species, Blumea chishangensis S. W. Chung, Z. H. Chen, S. H. Liu & W. J. Huang ...

Abstract	Background: Blumea plants are widely distributed in the tropical areas of Asia, Africa, and Australia, especially tropical Asia. Limited studies left the taxonomy and infrageneric phylogeny of Blumea insubstantial. Here, a new species, Blumea chishangensis S. W. Chung, Z. H. Chen, S. H. Liu & W. J. Huang, from Taiwan is described, and an extended phylogeny is reconstructed to provide new perceptions of Blumea evolution. Results: The new species is distinguished from B. hieraciifolia by the following features: leaf blade sparsely pilose or glabrescent (vs. silky villous), the leaves margins regularly remote mucronulate (vs. double serrate or dentate), capitula pedicelled (vs. capitula sessile or subsessile), and leaves basal rosette or sub-basal rosette and a few cauline (vs. mostly cauline). Phylogenetic analysis based on the ITS, trnL-trnF, and trnH-psbA regions places the new species in the subclade II in B. lacera clade and shows a close relationship with B. axillaris and B. oxyodonta. A key to Blumea species in Taiwan and the studied species in the subclade II is provided. Moreover, the evolutionary inferences of B. conspicua, B. linearis, and B. sinuata are first reported here. The paraphyly of B. formosana and B. sinuata are also revealed for the first time. Conclusions: Both morphological and molecular data support that B. chishangensis is a new species. Our phylogeny highlights the need for further taxonomic and evolutionary studies on Blumea.
Language	English
Publishing date	2022-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2432110-2
ISSN	1999-3110 ; 1817-406X
ISSN (online)	1999-3110
ISSN	1817-406X
DOI	10.1186/s40529-022-00350-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rediscovery of an ‘Extinct’ species Scleria sumatrensis Retz. in Taiwan using both morphological and molecular authentications

Shih-Hui Liu / Chau-Ching Huang / Chun-Kuei Liao

Taiwania, Vol 66, Iss 3, Pp 398-

2021 Volume 407

Abstract: Determining the correct conservation status of a species provides fundamental and critical information for species conservation policies. However, species traits and limited research efforts might decrease the accuracy of conservation assessments. ... ...

Abstract	Determining the correct conservation status of a species provides fundamental and critical information for species conservation policies. However, species traits and limited research efforts might decrease the accuracy of conservation assessments. Scleria sumatrensis has been considered a regionally extinct sedge plants in Taiwan, and the only, previous record of this species was from a collection provided by Urbain Faurie in 1914. More than one hundred years after Faurie’s record, we confirm the current occurrence of S. sumatrensis in Taiwan via morphological and molecular authentications in the present study. The morphological details of S. sumatrensis are provided based on the descriptions and illustrations. The conservation status for this species is reassigned to the Critically Endangered (CR) category. Further conservation efforts and research on S. sumatrensis are also discussed.
Keywords	conservation status ; cyperaceae ; red list ; rediscovery ; scleria sumatrensis ; species authentication ; Biology (General) ; QH301-705.5
Subject code	333
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	National Taiwan University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs.

Chiu, Shih-Hui / Ho, Wen-Lin / Sun, Yung-Chen / Kuo, Jean-Cheng / Huang, Jie-Rong

Communications biology

2022 Volume 5, Issue 1, Page(s) 400

Abstract: Paralogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively studied, but little is known about the roles that intrinsically disordered regions (IDRs) play in their ... ...

Abstract	Paralogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively studied, but little is known about the roles that intrinsically disordered regions (IDRs) play in their paralogs. Without a folded structure to restrain them, IDRs mutate more diversely along with evolution. However, how the diversity of IDRs in a paralog family affects their functions is unexplored. Using the RNA-binding protein Musashi family as an example, we applied multiple structural techniques and phylogenetic analysis to show how members in a paralog family have evolved their IDRs to different physicochemical properties but converge to the same function. In this example, the lower prion-like tendency of Musashi-1's IDRs, rather than Musashi-2's, is compensated by its higher α-helical propensity to assist their assembly. Our work suggests that, no matter how diverse they become, IDRs could evolve different traits to a converged function, such as liquid-liquid phase separation.
MeSH term(s)	Humans ; Phylogeny ; Proteins/metabolism
Chemical Substances	Proteins
Language	English
Publishing date	2022-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03354-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Blumea chishangensis sp. nov. (Asteraceae: Inuleae) from Taiwan and new insights into the phylogeny of Blumea

Chung, Shih-Wen / Huang, Wei-Jie / Chen, Zhi-Hao / Liu, Shih-Hui

Botanical studies. 2022 Dec., v. 63, no. 1

2022

Abstract: ... insubstantial. Here, a new species, Blumea chishangensis S. W. Chung, Z. H. Chen, S. H. Liu & W. J. Huang ...

Abstract	BACKGROUND: Blumea plants are widely distributed in the tropical areas of Asia, Africa, and Australia, especially tropical Asia. Limited studies left the taxonomy and infrageneric phylogeny of Blumea insubstantial. Here, a new species, Blumea chishangensis S. W. Chung, Z. H. Chen, S. H. Liu & W. J. Huang, from Taiwan is described, and an extended phylogeny is reconstructed to provide new perceptions of Blumea evolution. RESULTS: The new species is distinguished from B. hieraciifolia by the following features: leaf blade sparsely pilose or glabrescent (vs. silky villous), the leaves margins regularly remote mucronulate (vs. double serrate or dentate), capitula pedicelled (vs. capitula sessile or subsessile), and leaves basal rosette or sub-basal rosette and a few cauline (vs. mostly cauline). Phylogenetic analysis based on the ITS, trnL-trnF, and trnH-psbA regions places the new species in the subclade II in B. lacera clade and shows a close relationship with B. axillaris and B. oxyodonta. A key to Blumea species in Taiwan and the studied species in the subclade II is provided. Moreover, the evolutionary inferences of B. conspicua, B. linearis, and B. sinuata are first reported here. The paraphyly of B. formosana and B. sinuata are also revealed for the first time. CONCLUSIONS: Both morphological and molecular data support that B. chishangensis is a new species. Our phylogeny highlights the need for further taxonomic and evolutionary studies on Blumea.
Keywords	Blumea ; leaf blade ; new species ; paraphyly ; Africa ; Australia ; Taiwan
Language	English
Dates of publication	2022-12
Size	p. 21.
Publishing place	Springer Nature Singapore
Document type	Article
ZDB-ID	2432110-2
ISSN	1999-3110
ISSN	1999-3110
DOI	10.1186/s40529-022-00350-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Selection for tameness, a key behavioral trait of domestication, increases adult hippocampal neurogenesis in foxes.

Huang, Shihhui / Slomianka, Lutz / Farmer, Andrew J / Kharlamova, Anastasiya V / Gulevich, Rimma G / Herbeck, Yury E / Trut, Lyudmila N / Wolfer, David P / Amrein, Irmgard

Hippocampus

2015 Volume 25, Issue 8, Page(s) 963–975

Abstract: Work on laboratory and wild rodents suggests that domestication may impact on the extent of adult hippocampal neurogenesis and its responsiveness to regulatory factors. There is, however, no model of laboratory rodents and their nondomesticated ... ...

Abstract	Work on laboratory and wild rodents suggests that domestication may impact on the extent of adult hippocampal neurogenesis and its responsiveness to regulatory factors. There is, however, no model of laboratory rodents and their nondomesticated conspecifics that would allow a controlled comparison of the effect of domestication. Here, we present a controlled within-species comparison of adult hippocampal neurogenesis in farm-bred foxes (Vulpes vulpes) that differ in their genetically determined degree of tameness. Quantitative comparisons of cell proliferation (Ki67) and differentiating cells of neuronal lineage (doublecortin, DCX) in the hippocampus of foxes were performed as a proxy for neurogenesis. Higher neurogenesis was observed in tameness-selected foxes, notably in an extended subgranular zone of the middle and temporal compartments of the hippocampus. Increased neurogenesis is negatively associated with aggressive behavior. Across all animals, strong septotemporal gradients were found, with higher numbers of proliferating cells and young neurons relative to resident granule cells in the temporal than in the septal hippocampus. The opposite gradient was found for the ratio of DCX/Ki67- positive cells. When tameness-selected and unselected foxes are compared with rodents and primates, proliferation is similar, while the number of young neurons is higher. The difference may be mediated by an extended period of differentiation or higher rate of survival. On the background of this species-specific neurogenic pattern, selection of foxes for a single behavioral trait key to domestication, i.e., genetic tameness, is accompanied by global and region-specific increases in neurogenesis.
MeSH term(s)	Aggression/physiology ; Analysis of Variance ; Animals ; Animals, Domestic/physiology ; Cell Count ; Cell Differentiation ; Cell Proliferation/physiology ; Entorhinal Cortex/cytology ; Foxes/anatomy & histology ; Hippocampus/cytology ; Ki-67 Antigen/metabolism ; Male ; Microtubule-Associated Proteins/metabolism ; Neurogenesis/physiology ; Neurons/physiology ; Neuropeptides/metabolism
Chemical Substances	Ki-67 Antigen ; Microtubule-Associated Proteins ; Neuropeptides ; doublecortin protein
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074352-2
ISSN	1098-1063 ; 1050-9631
ISSN (online)	1098-1063
ISSN	1050-9631
DOI	10.1002/hipo.22420
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Article ; Online: Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs

Shih-Hui Chiu / Wen-Lin Ho / Yung-Chen Sun / Jean-Cheng Kuo / Jie-rong Huang

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 12

Abstract: A comparison of structure-function relationship for intrinsically disordered regions (IDRs) among paralogs shows that differences in physicochemical properties of the IDR between paralogs are compensated for to converge on the same biophysical function. ...

Abstract	A comparison of structure-function relationship for intrinsically disordered regions (IDRs) among paralogs shows that differences in physicochemical properties of the IDR between paralogs are compensated for to converge on the same biophysical function.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Reappraisal of VEGF in the Pathogenesis of Kawasaki Disease.

Chen, Chun-Yu / Huang, Shih-Hui / Chien, Kuang-Jen / Lai, Tsung-Jen / Chang, Wei-Hsiang / Hsieh, Kai-Sheng / Weng, Ken-Pen

Children (Basel, Switzerland)

2022 Volume 9, Issue 9

Abstract: Vascular endothelial growth factor (VEGF) is an important factor in mediating the inflammation of Kawasaki disease (KD). The literature regarding the relationship between VEGF and KD is sparse. The purpose of this study was to investigate the correlation ...

Abstract	Vascular endothelial growth factor (VEGF) is an important factor in mediating the inflammation of Kawasaki disease (KD). The literature regarding the relationship between VEGF and KD is sparse. The purpose of this study was to investigate the correlation of VEGF and KD. In a prospective study of 42 Taiwanese KD patients (18.9 ± 12.2 months, M/F 22/20) treated with intravenous immunoglobulin (IVIG), a series of VEGF levels was measured from the acute to convalescent phases. KD patients were classified into two subgroups with (n =20) and without (n = 22) acute coronary artery lesions (CALs). Control samples were obtained from 30 febrile controls (19.1 ± 13.7 months, M/F 13/17). In KD patients, VEGF levels in the pre-IVIG acute phase were significantly higher than those in the subacute and convalescent phases (both p < 0.001). In KD patients with CALs, VEGF levels significantly increased immediately in the post-IVIG phase (p = 0.039), and then significantly decreased in the subacute phase (p = 0.002). KD patients with acute CALs had higher median VEGF levels than those without acute CALs from acute to convalescent phases. In the subacute phase, KD patients with acute CALs had significantly higher VEGF levels (p = 0.022) than those without acute CALs. Our data show that VEGF did not decrease after IVIG treatment, and increased significantly after IVIG treatment in KD patients with acute CALs in acute phase. VEGF might be related to the complications of CALs in KD patients.
Language	English
Publishing date	2022-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9091343
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Article ; Online: Identifying Circulating MicroRNA in Kawasaki Disease by Next-Generation Sequencing Approach

Ken-Pen Weng / Ching-Feng Cheng / Kuang-Jen Chien / Luo-Ping Ger / Shih-Hui Huang / Kuo-Wang Tsai

Current Issues in Molecular Biology, Vol 43, Iss 37, Pp 485-

2021 Volume 500

Abstract: Kawasaki disease (KD) typically occurs in children aged under 5 years and can cause coronary artery lesions (CALs). Early diagnosis and treatment with intravenous immunoglobulin can reduce the occurrence of CALs; therefore, identifying a good biomarker ... ...

Abstract	Kawasaki disease (KD) typically occurs in children aged under 5 years and can cause coronary artery lesions (CALs). Early diagnosis and treatment with intravenous immunoglobulin can reduce the occurrence of CALs; therefore, identifying a good biomarker for diagnosing KD is essential. Here, using next-generation sequencing in patients with recurrent KD, those with viral infection, and healthy controls, we identified dysregulated circulating microRNAs as diagnostic biomarkers for KD. Pathway enrichment analysis illustrated the putative role of these miRNAs in KD progression. Their expression levels were validated using real-time polymerase chain reaction (qPCR). Fifteen dysregulated circulating miRNAs (fold changes >2 and <0.5) were differentially expressed in the recurrent KD group compared with the viral infection and control groups. These miRNAs were significantly involved in the transforming growth factor-β, epithelial–mesenchymal transition, and cell apoptosis signaling pathways. Notably, their expression levels were frequently restored after intravenous immunoglobulin treatment. Among the candidates, miR-24-3p expression level was significantly higher in patients with recurrent KD compared with healthy controls or viral infection controls ( p < 0.001). Receiver operating characteristic analysis revealed that high miR-24-3p expression levels may be a potential biomarker for KD diagnosis. In conclusion, we identified miR-24-3p significantly higher in KD patients, which may be a potential diagnostic biomarker for KD.
Keywords	microRNA ; Kawasaki disease ; circulating biomarker ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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