LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 76

Search options

  1. Book ; Online ; Thesis: Vergleichende Neuropathologie der Bornavirus-Enzephalitis in Mensch und Tier und Korrelation mit dem klinischen Verlauf

    Vollmuth, Yannik Verfasser] / [Liesche-Starnecker, Friederike [Akademischer Betreuer] / Matiasek, Kaspar Gutachter] / [Liesche-Starnecker, Friederike [Gutachter]

    2024  

    Author's details Yannik Vollmuth ; Gutachter: Kaspar Matiasek, Friederike Liesche-Starnecker ; Betreuer: Friederike Liesche-Starnecker
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online ; Thesis: Multimodale Quantifizierung der Heterogenität in Glioblastomen und ihre klinische Relevanz

    Prokop, Georg [Verfasser] / Liesche-Starnecker, Friederike [Akademischer Betreuer] / Schmidt-Graf, Friederike [Gutachter] / Wiestler, Benedikt [Gutachter] / Liesche-Starnecker, Friederike [Gutachter]

    2024  

    Author's details Georg Prokop ; Gutachter: Friederike Schmidt-Graf, Benedikt Wiestler, Friederike Liesche-Starnecker ; Betreuer: Friederike Liesche-Starnecker
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.

    Wu, Yang / Franzmeier, Sophie / Liesche-Starnecker, Friederike / Schlegel, Jürgen

    Cells

    2023  Volume 12, Issue 21

    Abstract: Temozolomide (TMZ) is standard treatment for glioblastoma (GBM); nonetheless, resistance and tumor recurrence are still major problems. In addition to its association with recurrent GBM and TMZ resistance, ALDH1A3 has a role in autophagy-dependent ... ...

    Abstract Temozolomide (TMZ) is standard treatment for glioblastoma (GBM); nonetheless, resistance and tumor recurrence are still major problems. In addition to its association with recurrent GBM and TMZ resistance, ALDH1A3 has a role in autophagy-dependent ferroptosis activation. In this study, we treated TMZ-resistant LN229 human GBM cells with the ferroptosis inducer RSL3. Remarkably, TMZ-resistant LN229 clones were also resistant to ferroptosis induction, although lipid peroxidation was induced by RSL3. By using Western blotting, we were able to determine that ALDH1A3 was down-regulated in TMZ-resistant LN229 cells. Most intriguingly, the cell viability results showed that only those clones that up-regulated ALDH1A3 after TMZ withdrawal became re-sensitized to ferroptosis induction. The recovery of ALDH1A3 expression appeared to be regulated by EGFR-dependent PI3K pathway activation since Akt was activated only in ALDH1A3 high clones. Blocking the EGFR signaling pathway with the EGFR inhibitor AG1498 decreased the expression of ALDH1A3. These findings shed light on the potential application of RSL3 in the treatment of glioblastoma relapse.
    MeSH term(s) Humans ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; ErbB Receptors/metabolism ; Ferroptosis ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Neoplasm Recurrence, Local ; Phosphatidylinositol 3-Kinases ; Temozolomide/pharmacology
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Temozolomide (YF1K15M17Y) ; aldehyde dehydrogenase (NAD(P)+) (EC 1.2.1.5)
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12212522
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: 18

    Bayas, Antonios / Menacher, Martina / Lapa, Constantin / Tappe, Dennis / Maurer, Christoph / Liesche-Starnecker, Friederike / Schneider, Hauke / Naumann, Markus

    Lancet (London, England)

    2024  Volume 403, Issue 10427, Page(s) 665–666

    MeSH term(s) Animals ; Humans ; Positron Emission Tomography Computed Tomography ; Borna disease virus/genetics ; Encephalitis ; Fluorodeoxyglucose F18 ; Magnetic Resonance Imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(24)00049-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online ; Thesis: Intratumorale Heterogenität von Glioblastomen -

    Mayer, Karoline Elisabeth Verfasser] / [Liesche-Starnecker, Friederike [Akademischer Betreuer] / Schmidt-Graf, Friederike Gutachter] / Wostrack, Maria [Gutachter] / [Liesche-Starnecker, Friederike [Gutachter]

    Subtypenausprägung in Primärtumoren und korrespondierenden Rezidiven

    2022  

    Author's details Karoline Elisabeth Mayer ; Gutachter: Friederike Schmidt-Graf, Maria Wostrack, Friederike Liesche-Starnecker ; Betreuer: Friederike Liesche-Starnecker
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis.

    Aftahy, A Kaywan / Butenschoen, Vicki M / Hoenikl, Lisa / Liesche-Starnecker, Friederike / Wiestler, Benedikt / Schmidt-Graf, Friederike / Meyer, Bernhard / Gempt, Jens

    BMC neurology

    2023  Volume 23, Issue 1, Page(s) 87

    Abstract: Background: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.: Case presentation: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented ...

    Abstract Background: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.
    Case presentation: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating.
    Conclusions: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.
    MeSH term(s) Child ; Male ; Young Adult ; Humans ; Adult ; Spinal Neoplasms/complications ; Spinal Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Bone and Bones ; Antineoplastic Combined Chemotherapy Protocols ; Glioma
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-023-03135-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online ; Thesis: Implementation der Konfokalen Laserendomikroskopie für digitale Biopsien von Hirntumoren

    Idzikowski, Maria Katharina [Verfasser] / Schlegel, Jürgen [Akademischer Betreuer] / Schlegel, Jürgen [Gutachter] / Liesche-Starnecker, Friederike [Gutachter]

    2023  

    Author's details Maria Katharina Idzikowski ; Gutachter: Jürgen Schlegel, Friederike Liesche-Starnecker ; Betreuer: Jürgen Schlegel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Comparative Study of Virus and Lymphocyte Distribution with clinical Data suggests early high dose Immunosuppression as potential Key Factor for the Therapy of Patients with BoDV-1 Infection.

    Vollmuth, Yannik / Jungbäck, Nicola / Mögele, Tatiana / Schmidt-Graf, Friederike / Wunderlich, Silke / Schimmel, Mareike / Rothe, Camilla / Stark, Leonhard / Schlegel, Jürgen / Rieder, Georg / Richter, Thomas / Schaller, Tina / Tappe, Dennis / Märkl, Bruno / Matiasek, Kaspar / Liesche-Starnecker, Friederike

    Emerging microbes & infections

    2024  , Page(s) 2350168

    Abstract: Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and ... ...

    Abstract Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and understanding its pathomechanism is of utmost relevance.Aim of this study was to compare the extent and distribution pattern of cerebral inflammation with the clinical course of disease, and individual therapeutic procedures.For this, autoptic brain material from seven patients with fatal BVE was included in this study. Tissue was stained immunohistochemically for pan-lymphocytic marker CD45, the nucleoprotein of BoDV-1, as well as glial marker GFAP and microglial marker Iba1. Sections were digitalized and counted for CD45-positive and BoDV-1-positive cells. For GFAP and Iba1, a semiquantitative score was determined. Furthermore, detailed information about the individual clinical course and therapy were retrieved and summarized in a standardized way.Analysis of the distribution of lymphocytes shows interindividual patterns. In contrast, when looking at the BoDV-1-positive glial cells and neurons, a massive viral involvement in the brain stem was noticeable. Three of the seven patients received early high-dose steroids, which led to a significantly lower lymphocytic infiltration of the central nervous tissue and a longer survival compared to the patients who were treated with steroids later in the course of disease.This study highlights the potential importance of early high-dose immunosuppressive therapy in BVE. Our findings hint at a promising treatment option which should be corroborated in future observational or prospective therapy studies.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2024.2350168
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Online ; Thesis: The role of aldehyde dehydrogenase 1 in the combined treatment of C6 glioblastoma cells with cold atmospheric plasma and standard radiotherapy

    Gantzkow, Alicia [Verfasser] / Schlegel, Jürgen [Akademischer Betreuer] / Schlegel, Jürgen [Gutachter] / Liesche-Starnecker, Friederike [Gutachter]

    2023  

    Author's details Alicia Gantzkow ; Gutachter: Jürgen Schlegel, Friederike Liesche-Starnecker ; Betreuer: Jürgen Schlegel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Primary Bone Tumors of the Spine-Proposal for Treatment Based on a Single Centre Experience.

    Lange, Nicole / Jörger, Ann-Kathrin / Ryang, Yu-Mi / Liesche-Starnecker, Friederike / Gempt, Jens / Meyer, Bernhard

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: This study reports a large single-center series of primary bone tumors of the spine (PBTs). We aimed to review the concepts for management, as this kind of tumor represents a very rare entity, and also propose a new treatment algorithm. Retrospective ... ...

    Abstract This study reports a large single-center series of primary bone tumors of the spine (PBTs). We aimed to review the concepts for management, as this kind of tumor represents a very rare entity, and also propose a new treatment algorithm. Retrospective analysis revealed 92 patients receiving surgery for PBTs from 2007 to 2019 at our center. They were analyzed based on surgical management and the course of the disease. A total of 145 surgical procedures were performed (50 cervical, 46 thoracic, 28 lumbar, and 21 sacral). Complete tumor resection was achieved in 65%, of which 22% showed tumor recurrence during follow-up (mean time to recurrence 334 days). The five-year mortality rate was significantly lower after complete resection (3% versus 25% after subtotal resection). Most of the patients improved in their symptoms through surgery. Regarding the tumor entity, the most common PBTs were vertebral hemangiomas (20%), osteoid osteomas (15%), and chordomas (16%). The Enneking graduation system showed a good correlation with the risk of recurrence and mortality. Complete resection in PBTs increased survival rates and remains the method of choice. Thus, quality of life-especially with a higher extent of resection-should be considered.
    Language English
    Publishing date 2022-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12092264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top