LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16706

Search options

  1. Article ; Online: Intermolecular radical cation Diels-Alder (RCDA) reaction of bicyclooctadienes: biomimetic formal total synthesis of kingianin A and total syntheses of kingianins D, F, H, and J.

    Lim, Hee Nam / Parker, Kathlyn A

    The Journal of organic chemistry

    2014  Volume 79, Issue 3, Page(s) 919–926

    Abstract: Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were ... without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates ... prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand's one ...

    Abstract Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were obtained by the intermolecular radical cation Diels-Alder (RCDA) reaction. Each isomer was cleanly isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates from commercially available materials in 10, 13, 9, and 17 steps, respectively. Kingianin A has already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand's one-step, three-carbon homologation.
    MeSH term(s) Bridged Bicyclo Compounds/chemistry ; Cations/chemistry ; Chromatography, High Pressure Liquid ; Cycloaddition Reaction ; Molecular Structure ; Polycyclic Aromatic Hydrocarbons/chemical synthesis ; Polycyclic Aromatic Hydrocarbons/chemistry ; Stereoisomerism
    Chemical Substances Bridged Bicyclo Compounds ; Cations ; Polycyclic Aromatic Hydrocarbons ; kingianin A
    Language English
    Publishing date 2014-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo402082y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Intermolecular Radical Cation Diels–Alder (RCDA) Reaction of Bicyclooctadienes: Biomimetic Formal Total Synthesis of Kingianin A and Total Syntheses of Kingianins D, F, H, and J

    Lim, Hee Nam / Parker Kathlyn A

    Journal of organic chemistry. 2014 Feb. 07, v. 79, no. 3

    2014  

    Abstract: Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were ... isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way ... already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied ...

    Abstract Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were obtained by the intermolecular radical cation Diels–Alder (RCDA) reaction. Each isomer was cleanly isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates from commercially available materials in 10, 13, 9, and 17 steps, respectively. Kingianin A has already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand’s one-step, three-carbon homologation.
    Keywords biomimetics ; cations ; cycloaddition reactions ; high performance liquid chromatography ; isomers ; organic chemistry ; organic compounds
    Language English
    Dates of publication 2014-0207
    Size p. 919-926.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Fjo402082y
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 49/42: Show issues
    Z 7.1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Consumer Experience of Mistreatment and Fraud in Financial Services: Implications from an Integrative Consumer Vulnerability Framework.

    Lim, H / Letkiewicz, J C

    Journal of consumer policy

    2023  Volume 46, Issue 2, Page(s) 109–135

    Abstract: This study utilizes the National Financial Well-Being Survey (NFWS) from the Consumer Financial Protection Bureau (CFPB) to investigate the profiles of American consumers who experience mistreatment or a type of fraud in financial services (compromised ... ...

    Abstract This study utilizes the National Financial Well-Being Survey (NFWS) from the Consumer Financial Protection Bureau (CFPB) to investigate the profiles of American consumers who experience mistreatment or a type of fraud in financial services (compromised accounts). An integrative consumer vulnerability framework was used as the theoretical framework to examine how disadvantaged consumer characteristics and vulnerable consumer characteristics are associated with mistreatment and compromised accounts. Consumers in vulnerable states, due to low financial capability, cognitive decline, material hardships, financial shocks, and more exposure to various financial services, were more likely to report experiencing mistreatment and having their financial accounts compromised. Consumers from higher socio-economic status were more likely to have been victims of mistreatment and compromised accounts in financial services. These findings offer implications for consumer financial education and protection.
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1477235-8
    ISSN 1573-0700 ; 0342-5843 ; 0168-7034
    ISSN (online) 1573-0700
    ISSN 0342-5843 ; 0168-7034
    DOI 10.1007/s10603-023-09535-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model.

    Lim, Jeonghyun / Myung, Heejoon / Lim, Daejin / Song, Miryoung

    Journal of biomedical science

    2024  Volume 31, Issue 1, Page(s) 36

    Abstract: Background: This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these ...

    Abstract Background: This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these challenges.
    Methods: Tha-PA90 incorporates an antimicrobial peptide (AMP) called thanatin at its N-terminus, enhancing bacterial outer membrane permeability and reducing host immune responses. PA90 was selected as the endolysin component. The antibacterial activity of the purified Tha-PA90 was evaluated using an in vitro colony-forming unit (CFU) reduction assay and a membrane permeability test. A549 cells were utilized to measure the penetration into the cytosol and the cytotoxicity of Tha-PA90. Finally, infection control was monitored in A. baumannii infected mice following the intraperitoneal administration of Tha-PA90.
    Results: Tha-PA90 demonstrated remarkable in vitro efficacy, completely eradicating A. baumannii strains, even drug-resistant variants, at a low concentration of 0.5 μM. Notably, it outperformed thanatin, achieving only a < 3-log reduction at 4 μM. Tha-PA90 exhibited 2-3 times higher membrane permeability than a PA90 and thanatin mixture or PA90 alone. Tha-PA90 was found within A549 cells' cytosol with no discernible cytotoxic effects. Furthermore, Tha-PA90 administration extended the lifespan of A. baumannii-infected mice, reducing bacterial loads in major organs by up to 3 logs. Additionally, it decreased proinflammatory cytokine levels (TNF-α and IL-6), reducing the risk of sepsis from rapid bacterial lysis. Our findings indicate that Tha-PA90 is a promising solution for combating drug-resistant A. baumannii. Its enhanced efficacy, low cytotoxicity, and reduction of proinflammatory responses render it a potential candidate for infection control.
    Conclusions: This study underscores the significance of engineered endolysins in addressing the pressing challenge of drug-resistant pathogens and offers insights into improved infection management strategies.
    MeSH term(s) Animals ; Mice ; Acinetobacter baumannii ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides ; Anti-Bacterial Agents/pharmacology ; Acinetobacter Infections/drug therapy ; Microbial Sensitivity Tests ; Endopeptidases
    Chemical Substances thanatin ; endolysin (EC 3.4.99.-) ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides ; Anti-Bacterial Agents ; Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193378-1
    ISSN 1423-0127 ; 1021-7770
    ISSN (online) 1423-0127
    ISSN 1021-7770
    DOI 10.1186/s12929-024-01027-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4037: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Conference proceedings: Safety and efficacy of biliary endoscopic balloon-based laser treatment vs. endobiliary radiofrequency ablation in swine models

    Jeong, S. / Lim, J. H. / Lee, J. / Lee, D. H.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783253
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A Bilayer Method for Measuring Toughness and Strength of Dental Ceramics.

    Chai, H / Russ, J / Vardhaman, S / Lim, C H / Zhang, Y

    Journal of dental research

    2024  Volume 103, Issue 4, Page(s) 419–426

    Abstract: The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength ... ...

    Abstract The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength σ
    MeSH term(s) Materials Testing ; Ceramics/chemistry ; Tooth ; Dentistry ; Dental Porcelain ; Surface Properties
    Chemical Substances Dental Porcelain (12001-21-7)
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345231225445
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.75: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 262: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Loneliness as a risk factor for dementia and other adverse health outcomes.

    Na, Peter J / Lim, Yen Ying / Pietrzak, Robert H

    International psychogeriatrics

    2023  Volume 35, Issue 6, Page(s) 271–274

    MeSH term(s) Humans ; Loneliness ; Risk Factors ; Dementia ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S104161022300011X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2621: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 513: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Positive rate for carbapenem-resistant Enterobacterales in hospital water environment: a single-centre study in South Korea.

    Jo, J L / Lee, J Y / Kim, J Y / Lim, Y-J / Kim, E O / Jung, J / Kim, S-H

    The Journal of hospital infection

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Letter
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2024.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Investigating the Relevance of Cyclic Adenosine Monophosphate Response Element-Binding Protein to the Wound Healing Process: An In Vivo Study Using Photobiomodulation Treatment.

    Kim, Sungyeon / Park, Jion / Choi, Younghoon / Jeon, Hongbae / Lim, Namkyu

    International journal of molecular sciences

    2024  Volume 25, Issue 9

    Abstract: ... with a 6 mm diameter round shape were treated five times with an 808 nm laser every other day (total 60 J ... analysis assessed the epidermal regeneration and collagen expression of skin and oral tissue with H&E and ...

    Abstract Monitoring inflammatory cytokines is crucial for assessing healing process and photobiomodulation (PBM) enhances wound healing. Meanwhile, cAMP response element-binding protein (CREB) is a regulator of cellular metabolism and proliferation. This study explored potential links between inflammatory cytokines and the activity of CREB in PBM-treated wounds. A total of 48 seven-week-old male SD rats were divided into four groups (wound location, skin or oral; treatment method, natural healing or PBM treatment). Wounds with a 6 mm diameter round shape were treated five times with an 808 nm laser every other day (total 60 J). The wound area was measured with a caliper and calculated using the elliptical formula. Histological analysis assessed the epidermal regeneration and collagen expression of skin and oral tissue with H&E and Masson's trichrome staining. Pro-inflammatory (TNF-α) and anti-inflammatory (TGF-β) cytokines were quantified by RT-PCR. The ratio of phosphorylated CREB (p-CREB) to unphosphorylated CREB was identified through Western blot. PBM treatment significantly reduced the size of the wounds on day 3 and day 7, particularly in the skin wound group (
    MeSH term(s) Animals ; Wound Healing/radiation effects ; Low-Level Light Therapy/methods ; Male ; Rats ; Cyclic AMP Response Element-Binding Protein/metabolism ; Rats, Sprague-Dawley ; Skin/metabolism ; Skin/radiation effects ; Skin/pathology ; Skin/injuries ; Cytokines/metabolism ; Phosphorylation/radiation effects ; Tumor Necrosis Factor-alpha/metabolism ; Collagen/metabolism ; Transforming Growth Factor beta/metabolism
    Chemical Substances Cyclic AMP Response Element-Binding Protein ; Cytokines ; Tumor Necrosis Factor-alpha ; Collagen (9007-34-5) ; Transforming Growth Factor beta
    Language English
    Publishing date 2024-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094838
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Scapular Elevation Sign - A New Sign in Evaluation of Thoracic Outlet Syndrome.

    Nordback, Panu H / Sebastin, Sandeep J / Yong, Zachary Z / Lee, Ellen Y / Lim, Aymeric Y T

    The journal of hand surgery Asian-Pacific volume

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-05-10
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2848651-1
    ISSN 2424-8363 ; 2424-8355
    ISSN (online) 2424-8363
    ISSN 2424-8355
    DOI 10.1142/S2424835524500255
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5911: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top