LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 254798

Search options

  1. Article ; Online: L

    Chen, Cheng-Neng / Wang, Mao-Hsien / Soung, Hung-Sheng / Chen, Shu-Mei / Fang, Chih-Hsiang / Lin, Yi-Wen / Tseng, Hsiang-Chien

    Neurotoxicity research

    2022  Volume 40, Issue 1, Page(s) 241–258

    Abstract: Rotenone (RO)-induced neurotoxicity exhibits pathophysiological features similar to those reported in patients with Parkinson's disease (PD), such as nitrosative and oxidative stress, mitochondrial dysfunction, and neural cytoarchitecture alterations in ... ...

    Abstract Rotenone (RO)-induced neurotoxicity exhibits pathophysiological features similar to those reported in patients with Parkinson's disease (PD), such as nitrosative and oxidative stress, mitochondrial dysfunction, and neural cytoarchitecture alterations in the substantia nigra pars compacta (SNpc)/striatum (ST), which has been used for decades as an animal model of PD in humans.
    MeSH term(s) Animals ; Disease Models, Animal ; Glutamates/therapeutic use ; Humans ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Parkinsonian Disorders/metabolism ; Rats ; Rotenone/toxicity
    Chemical Substances Glutamates ; Neuroprotective Agents ; Rotenone (03L9OT429T) ; theanine (8021PR16QO)
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-021-00451-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: l

    Zheng, Wenming / Lu, Cheng / Lin, Zhouchen / Zhang, Tong / Cui, Zhen / Yang, Wankou

    IEEE transactions on neural networks and learning systems

    2018  Volume 30, Issue 10, Page(s) 2898–2915

    Abstract: ... criterion is based on the l ...

    Abstract Fisher's criterion is one of the most popular discriminant criteria for feature extraction. It is defined as the generalized Rayleigh quotient of the between-class scatter distance to the within-class scatter distance. Consequently, Fisher's criterion does not take advantage of the discriminant information in the class covariance differences, and hence, its discriminant ability largely depends on the class mean differences. If the class mean distances are relatively large compared with the within-class scatter distance, Fisher's criterion-based discriminant analysis methods may achieve a good discriminant performance. Otherwise, it may not deliver good results. Moreover, we observe that the between-class distance of Fisher's criterion is based on the l
    Language English
    Publishing date 2018-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2018.2863264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: The L-lactate dehydrogenases of

    Florek, Lindsey C / Lin, Xi / Lin, Yu-Cheng / Lin, Min-Han / Chakraborty, Arijit / Price-Whelan, Alexa / Tong, Liang / Rahme, Laurence / Dietrich, Lars E P

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.21.586142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: An L

    Li, Xiong / Lin, Yangkai / Meng, Xu / Qiu, Yangping / Hu, Bo

    IEEE journal of biomedical and health informatics

    2021  Volume 25, Issue 9, Page(s) 3677–3684

    Abstract: Although the neuroimaging measures build a bridge between genetic variants and disease phenotypes, an assessment of single nucleotide variants changes in brain structure and their clinically influence on the progression of Alzheimer's disease remain ... ...

    Abstract Although the neuroimaging measures build a bridge between genetic variants and disease phenotypes, an assessment of single nucleotide variants changes in brain structure and their clinically influence on the progression of Alzheimer's disease remain largely preliminary. Note that each variant has very weak correlation signal to neuroimaging measures or Alzheimer's disease phenotypes. Therefore, traditional sparse regression-based image genetics approaches confront with unresolvable features, relative high regression error or inapplicability of high-dimensional data. Adopting an [Formula: see text] regularization method, we significantly elevate the regression accuracy of imaging genetics compared with group-sparse multitask regression method. With further analysis on the simulation results, we conclude that multiple regression tasks model may be unsuitable for image genetics. In addition, we carried out a whole genome association analysis between genetic variants (about 388 million loci) and phenotypes (cognition normal, mild cognitive impairment and Alzheimer's disease) with using the [Formula: see text] regularization method. After annotating the effect of all variants by Ensembl Variant Effect Predictor (VEP), our method locates 33 missense variants which can explain 40% phenotype variance. Then, we mapped each missense variant to the nearest gene and carried out pathway enrichment analysis. The Notch signaling pathway and Apoptosis pathway have been reported to be related to the formation of Alzheimer's disease.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Brain/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Genome-Wide Association Study ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2021.3093027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: L-AutoDA

    Guo, Ping / Liu, Fei / Lin, Xi / Zhao, Qingchuan / Zhang, Qingfu

    Leveraging Large Language Models for Automated Decision-based Adversarial Attacks

    2024  

    Abstract: ... against. This work introduces L-AutoDA (Large Language Model-based Automated Decision-based Adversarial ... to automate the design of these attacks. By iteratively interacting with LLMs in an evolutionary framework, L ... We demonstrate the efficacy of L-AutoDA on CIFAR-10 dataset, showing significant improvements over baseline ...

    Abstract In the rapidly evolving field of machine learning, adversarial attacks present a significant challenge to model robustness and security. Decision-based attacks, which only require feedback on the decision of a model rather than detailed probabilities or scores, are particularly insidious and difficult to defend against. This work introduces L-AutoDA (Large Language Model-based Automated Decision-based Adversarial Attacks), a novel approach leveraging the generative capabilities of Large Language Models (LLMs) to automate the design of these attacks. By iteratively interacting with LLMs in an evolutionary framework, L-AutoDA automatically designs competitive attack algorithms efficiently without much human effort. We demonstrate the efficacy of L-AutoDA on CIFAR-10 dataset, showing significant improvements over baseline methods in both success rate and computational efficiency. Our findings underscore the potential of language models as tools for adversarial attack generation and highlight new avenues for the development of robust AI systems.

    Comment: Under Review of IJCNN 2024
    Keywords Computer Science - Cryptography and Security ; Computer Science - Artificial Intelligence ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2024-01-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Use of ultrasound to increase the catalytic activity of α-L-rhamnosidase.

    Qi, Chen / Li, Le / Yu, Kunpeng / Lin, Yanling / Li, Lijun

    Preparative biochemistry & biotechnology

    2024  , Page(s) 1–5

    Abstract: α-L-rhamnosidase (Rha) is ubiquitous in nature and has high feasibility in the food and ...

    Abstract α-L-rhamnosidase (Rha) is ubiquitous in nature and has high feasibility in the food and biotechnology industries. A green and environmentally friendly method was used to improve the activity of Rha. Here, we show that the effects of ultrasound treatment on the Rha. Ultrasonic treatment at 80 W for 10 min yielded the highest enzyme activity. Treatment increased enzyme activity by 26.3% and half-life by 124 min. Further, treatment increased the catalytic efficiency of Rha and increased the substrate conversion rate by 33.88%. These results demonstrate that ultrasound increases the catalytic activity and stability of Rha. Thus, ultrasonic treatment of Rha is cost-effective on the industrial scale.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1322522-4
    ISSN 1532-2297 ; 1082-6068
    ISSN (online) 1532-2297
    ISSN 1082-6068
    DOI 10.1080/10826068.2024.2326877
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 821: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Microbial α-L-arabinofuranosidases: diversity, properties, and biotechnological applications.

    Long, Liangkun / Lin, Qunying / Wang, Jing / Ding, Shaojun

    World journal of microbiology & biotechnology

    2024  Volume 40, Issue 3, Page(s) 84

    Abstract: ... linked xylose residues branched by high content of α-L-arabinofuranosyl (Araf) residues along ... on the synergism of main-chain enzymes and de-branching enzymes. Exo-α-L-arabinofuranosidases (ABFs) catalyze ... the hydrolysis of terminal non-reducing α-1,2-, α-1,3- or α-1,5- linked α-L-Araf residues from arabinose ...

    Abstract Arabinoxylans (AXs) are hemicellulosic polysaccharides consisting of a linear backbone of β-1,4-linked xylose residues branched by high content of α-L-arabinofuranosyl (Araf) residues along with other side-chain substituents, and are abundantly found in various agricultural crops especially cereals. The efficient bioconversion of AXs into monosaccharides, oligosaccharides and/or other chemicals depends on the synergism of main-chain enzymes and de-branching enzymes. Exo-α-L-arabinofuranosidases (ABFs) catalyze the hydrolysis of terminal non-reducing α-1,2-, α-1,3- or α-1,5- linked α-L-Araf residues from arabinose-substituted polysaccharides or oligosaccharides. ABFs are critically de-branching enzymes in bioconversion of agricultural biomass, and have received special attention due to their application potentials in biotechnological industries. In recent years, the researches on microbial ABFs have developed quickly in the aspects of the gene mining, properties of novel members, catalytic mechanisms, methodologies, and application technologies. In this review, we systematically summarize the latest advances in microbial ABFs, and discuss the future perspectives of the enzyme research.
    MeSH term(s) Glycoside Hydrolases/genetics ; Biotechnology ; Polysaccharides ; Oligosaccharides
    Chemical Substances alpha-N-arabinofuranosidase (EC 3.2.1.55) ; Glycoside Hydrolases (EC 3.2.1.-) ; Polysaccharides ; Oligosaccharides
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03882-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The protective effect of L-theanine on the intestinal barrier in heat-stressed organisms.

    Wang, Bin / Liu, Sha / Lin, Ling / Xu, Wei / Gong, Zhihua / Xiao, Wenjun

    Food & function

    2024  Volume 15, Issue 6, Page(s) 3036–3049

    Abstract: ... barrier of organisms. L-Theanine (LTA) attenuates heat stress-induced oxidative stress, inflammatory ...

    Abstract Heat stress caused by heatwaves, extreme temperatures, and other weather can damage the intestinal barrier of organisms. L-Theanine (LTA) attenuates heat stress-induced oxidative stress, inflammatory responses, and impaired immune function, but its protective effect on the intestinal barrier of heat-stressed organisms is unclear. In this study, low (100 mg kg
    MeSH term(s) Male ; Animals ; Mice ; Mice, Inbred C57BL ; Occludin ; Intestines ; RNA, Messenger ; Glutamates
    Chemical Substances theanine (8021PR16QO) ; Occludin ; RNA, Messenger ; Glutamates
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04459a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: DsbA-L: A Promising Therapeutic Target for Metabolic Diseases.

    Yang, Ming / Luo, Shilu / Yang, Jinfei / Chen, Wei / He, Liyu / Liu, Di / Wang, Xi / Xiao, Li / Sun, Lin

    Current medicinal chemistry

    2023  

    Abstract: ... for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism ... Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting ... we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological ...

    Abstract The increasing incidence of metabolic diseases, including obesity and diabetes, is a serious social public problem. Therefore, there is an urgent need to find effective prevention and treatment measures for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism. Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting the synthesis and secretion of adiponectin and maintaining mitochondrial homeostasis, and the abnormalities of these functions are also closely related to the occurrence and development of metabolic diseases. Here, we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological functions and the current research progress of DsbA-L in metabolic diseases, and found that DsbA-L may be a promising target for metabolic diseases.
    Language English
    Publishing date 2023-10-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673252630231018044159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Anti-inflammatory steroids from the stems of Solanum nigrum L.

    Deng, Junru / Wang, Lin / Jin, Qingyu / Zeng, Jia / Xu, Jingwen / He, Xiangjiu / Wang, Yihai

    Phytochemistry

    2023  Volume 210, Page(s) 113667

    Abstract: ... from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and ...

    Abstract Sixteen previously undescribed steroidal sapogenins along with two known ones were isolated from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and 2D NMR, HR-ESI-MS spectroscopy, the Mosher method, and X-ray diffraction analysis. Compounds 1-8 have an unusual F ring and 9-12 have a derived A ring, both of which are rare skeletons found in natural products. The biological evaluation showed that the isolated steroids exhibited inhibition of nitric oxide in the LPS-induced RAW 264.7 macrophages with IC
    MeSH term(s) Animals ; Mice ; Solanum nigrum/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/metabolism ; Macrophages/metabolism ; NF-kappa B/metabolism ; Steroids/chemistry ; Lipopolysaccharides/pharmacology ; Nitric Oxide ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells
    Chemical Substances Anti-Inflammatory Agents ; NF-kappa B ; Steroids ; Lipopolysaccharides ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113667
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top