Article ; Online: [The significance of autoantibodies against nodal and paranodal proteins in autoimmune nodopathies].
Rinsho shinkeigaku = Clinical neurology
2023 Volume 63, Issue 11, Page(s) 715–724
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is recognized as a syndrome caused by multiple pathologies. Since the 2010s, it has been clarified that autoantibodies against membranous proteins localized in the nodes of Ranvier and ... ...
Abstract | Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is recognized as a syndrome caused by multiple pathologies. Since the 2010s, it has been clarified that autoantibodies against membranous proteins localized in the nodes of Ranvier and paranodes are positive in subsets of CIDP patients, leading to proposing a new disease concept called autoimmune nodopathies, which is independent of CIDP, in the revised international CIDP guidelines. This article reviews the significance of these autoantibodies, especially anti-neurofascin 155 and anti-contactin 1 antibodies, which have been the most prevalent and achieved a higher degree of consensus. |
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MeSH term(s) | Humans ; Cell Adhesion Molecules ; Ranvier's Nodes/metabolism ; Ranvier's Nodes/pathology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ; Autoantibodies/metabolism ; Nerve Growth Factors |
Chemical Substances | Cell Adhesion Molecules ; Autoantibodies ; Nerve Growth Factors |
Language | Japanese |
Publishing date | 2023-10-25 |
Publishing country | Japan |
Document type | Review ; English Abstract ; Journal Article |
ZDB-ID | 604200-4 |
ISSN | 1882-0654 ; 0009-918X |
ISSN (online) | 1882-0654 |
ISSN | 0009-918X |
DOI | 10.5692/clinicalneurol.cn-001878 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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