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Article ; Online: Reply to Martin

Nichols, David P / Rowe, Steven M

American journal of respiratory and critical care medicine

2022 Volume 205, Issue 11, Page(s) 1366–1367

MeSH term(s)	Aminophenols/therapeutic use ; Benzodioxoles/therapeutic use ; Humans ; Indoles ; Lung ; Pyrazoles/adverse effects ; Pyridines ; Pyrrolidines ; Quinolones
Chemical Substances	Aminophenols ; Benzodioxoles ; Indoles ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones ; tezacaftor ; ivacaftor (1Y740ILL1Z) ; elexacaftor (RRN67GMB0V)
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202201-0042LE
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Article ; Online: Molecular imaging in oncology: Current impact and future directions.

Rowe, Steven P / Pomper, Martin G

CA: a cancer journal for clinicians

2021 Volume 72, Issue 4, Page(s) 333–352

Abstract: The authors define molecular imaging, according to the Society of Nuclear Medicine and Molecular Imaging, as the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living ... ...

Abstract	The authors define molecular imaging, according to the Society of Nuclear Medicine and Molecular Imaging, as the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems. Although practiced for many years clinically in nuclear medicine, expansion to other imaging modalities began roughly 25 years ago and has accelerated since. That acceleration derives from the continual appearance of new and highly relevant animal models of human disease, increasingly sensitive imaging devices, high-throughput methods to discover and optimize affinity agents to key cellular targets, new ways to manipulate genetic material, and expanded use of cloud computing. Greater interest by scientists in allied fields, such as chemistry, biomedical engineering, and immunology, as well as increased attention by the pharmaceutical industry, have likewise contributed to the boom in activity in recent years. Whereas researchers and clinicians have applied molecular imaging to a variety of physiologic processes and disease states, here, the authors focus on oncology, arguably where it has made its greatest impact. The main purpose of imaging in oncology is early detection to enable interception if not prevention of full-blown disease, such as the appearance of metastases. Because biochemical changes occur before changes in anatomy, molecular imaging-particularly when combined with liquid biopsy for screening purposes-promises especially early localization of disease for optimum management. Here, the authors introduce the ways and indications in which molecular imaging can be undertaken, the tools used and under development, and near-term challenges and opportunities in oncology.
MeSH term(s)	Animals ; Humans ; Magnetic Resonance Imaging ; Medical Oncology ; Molecular Imaging/methods ; Positron-Emission Tomography
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603553-x
ISSN	1542-4863 ; 0007-9235
ISSN (online)	1542-4863
ISSN	0007-9235
DOI	10.3322/caac.21713
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Article ; Online: The cutting edge: Promising oncology radiotracers in clinical development.

Oldan, Jorge D / Pomper, Martin G / Werner, Rudolf A / Higuchi, Takahiro / Rowe, Steven P

Diagnostic and interventional imaging

2024

Abstract: Molecular imaging moves forward with the development of new imaging agents, and among these are new radiotracers for nuclear medicine applications, particularly positron emission tomography (PET). A number of new targets are becoming accessible for use ... ...

Abstract	Molecular imaging moves forward with the development of new imaging agents, and among these are new radiotracers for nuclear medicine applications, particularly positron emission tomography (PET). A number of new targets are becoming accessible for use in oncologic applications. In this review, major new radiotracers in clinical development are discussed. Prominent among these is the family of fibroblast-activation protein-targeted agents that interact with the tumor microenvironment and may show superiority to 2-deoxy-2-[18F]fluoro-d-glucose in a subset of different tumor histologies. Additionally, carbonic anhydrase IX (CAIX) inhibitors are directed at clear cell renal cell carcinoma, which has long lacked an effective PET imaging agent. Those CAIX agents may also have utility in hypoxic tumors. Pentixafor, which binds to a transmembrane receptor, may similarly allow for visualization by PET of low-grade lymphomas, as well as being a second agent for multiple myeloma that opens theranostic possibilities. There are new adrenergic agents aimed at providing a PET-visible replacement to the single-photon-emitting radiotracer meta-[123I]iodobenzylguanidine (MIBG). Finally, in response to a major development in oncologic chemotherapy, there are new radiotracers targeted at assessing the suitability or use of immunotherapeutic agents. All of these and the existing evidence for their utility are discussed.
Language	English
Publishing date	2024-05-14
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2024.04.004
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Article: Thermal ecology of Northern Water Snakes (Nerodia sipedon) in a northern wetland in central Michigan.

Rowe, John W / Goerge, Tyler M / Martin, Chelsea E / Mulligan, William P

Journal of thermal biology

2022 Volume 105, Page(s) 103204

Abstract: Semi-aquatic north-temperate reptiles experience challenging environmental conditions for thermoregulation on both seasonal and daily bases. We studied the thermal biology of north-temperate Northern Water Snakes (Nerodia sipedon) in central Michigan by ... ...

Abstract	Semi-aquatic north-temperate reptiles experience challenging environmental conditions for thermoregulation on both seasonal and daily bases. We studied the thermal biology of north-temperate Northern Water Snakes (Nerodia sipedon) in central Michigan by remote radiotelemetry monitoring of snake body temperature (T
MeSH term(s)	Animals ; Body Temperature Regulation/physiology ; Colubridae ; Female ; Male ; Michigan ; Seasons ; Snakes ; Wetlands
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2022.103204
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Article ; Online: One Hundred Years of the Tracer Principle.

Hoberück, Sebastian / Zöphel, Klaus / Pomper, Martin G / Rowe, Steven P / Gafita, Andrei

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 12, Page(s) 1998–2000

Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.266458
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting.

McCabe, Alastair / Martin, Stewart / Rowe, Selene / Shah, Jagrit / Morgan, Paul S / Borys, Damian / Panek, Rafal

European radiology experimental

2024 Volume 8, Issue 1, Page(s) 27

Abstract: Background: Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many centres. We ...

Abstract	Background: Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many centres. We investigated if an alternative technique called oxygen-enhanced magnetic resonance imaging (OE-MRI) could be performed in HNSCC. Methods: A volumetric OE-MRI protocol for dynamic T1 relaxation time mapping was implemented on 1.5-T clinical scanners. Participants were scanned breathing room air and during high-flow oxygen administration. Oxygen-induced changes in T1 times (ΔT1) and R Results: Fifteen patients with HNSCC (median age 59 years, range 38 to 76) and 10 non-HNSCC subjects (median age 46.5 years, range 32 to 62) were scanned; the OE-MRI acquisition took less than 10 min and was well tolerated. Fifteen histologically confirmed primary tumours and 41 malignant nodal masses were identified. Median (range) of ΔT1 times and hypoxic fraction estimates for primary tumours were -3.5% (-7.0 to -0.3%) and 30.7% (6.5 to 78.6%) respectively. Radiotherapy-responsive and radiotherapy-resistant primary tumours had mean estimated hypoxic fractions of 36.8% (95% confidence interval [CI] 17.4 to 56.2%) and 59.0% (95% CI 44.6 to 73.3%), respectively (p = 0.111). Conclusions: We present a well-tolerated implementation of dynamic, volumetric OE-MRI of the head and neck region allowing discernment of differing oxygen responses within biopsy-confirmed HNSCC. Trial registration: ClinicalTrials.gov, NCT04724096 . Registered on 26 January 2021. Relevance statement: MRI of tumour hypoxia in head and neck cancer using routine clinical equipment is feasible and well tolerated and allows estimates of tumour hypoxic fractions in less than ten minutes. Key points: • Oxygen-enhanced MRI (OE-MRI) can estimate tumour hypoxic fractions in ten-minute scanning. • OE-MRI may be incorporable into routine clinical tumour imaging. • OE-MRI has the potential to predict outcomes after radiotherapy treatment.
MeSH term(s)	Adult ; Aged ; Humans ; Middle Aged ; Head and Neck Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Oxygen ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Tumor Hypoxia
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Clinical Study ; Journal Article
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-024-00429-1
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Article ; Online: Impact of residential PTSD treatment on suicide risk in veterans.

Pease, James L / Martin, Colleen E / Rowe, Claire / Chard, Kathleen M

Suicide & life-threatening behavior

2022 Volume 53, Issue 2, Page(s) 250–261

Abstract: Introduction: In 2019, 17 veterans died by suicide every day. Various suicide prevention treatments have emerged, yet limited research has explored the impact of Post Traumatic Stress Disorder (PTSD) treatment on suicidal ideation and behaviors.: ... ...

Abstract	Introduction: In 2019, 17 veterans died by suicide every day. Various suicide prevention treatments have emerged, yet limited research has explored the impact of Post Traumatic Stress Disorder (PTSD) treatment on suicidal ideation and behaviors. Methods: This study examines the impact of Cognitive Processing Therapy (CPT) on suicidal ideation among veterans in three residential PTSD programs (women's, men's, and PTSD/Traumatic Brain Injury). Interview and self-report data were collected from veterans (n = 446) throughout treatment. Results: Over 50% of veterans reported current suicidal ideation and a history of suicide attempts prior to treatment. Variables that predicted change in suicidal ideation included prior suicide attempt (β = 0.21, p = 0.022), change in CAPS-5 total score (β = 0.28, p = 0.038), employment status (β = -0.20, p = 0.035) and history of suicide attempt (β = 0.25, p = 0.009). Those without a previous suicide attempt made greater gains in CPT treatment than those with a previous suicide attempt. Conclusion: Following 7 weeks of CPT residential treatment, a decrease in PTSD symptoms was significantly associated with a reduction in suicidal ideation. Implications are that CPT can reduce suicide risk in a variety of Veteran cohorts with differing trauma types.
MeSH term(s)	Male ; Humans ; Female ; Veterans/psychology ; Stress Disorders, Post-Traumatic/psychology ; Residential Treatment ; Suicide, Attempted/psychology ; Suicidal Ideation
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	750058-0
ISSN	1943-278X ; 0047-4592 ; 0363-0234
ISSN (online)	1943-278X
ISSN	0047-4592 ; 0363-0234
DOI	10.1111/sltb.12939
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Article: vSPACE: Exploring Virtual Spatial Representation of Articular Chondrocytes at the Single-Cell Level.

Zhang, Chenyu / Wang, Honglin / Hong, Seung-Hyun / Olmer, Merissa / Swahn, Hannah / Lotz, Martin K / Maye, Peter / Rowe, David / Shin, Dong-Guk

bioRxiv : the preprint server for biology

2024

Abstract: Single cell RNA sequencing technology has been dramatically changing how gene expression studies are performed. However, its use has been limited to identifying subtypes of cells by comparing cells' gene expression levels in an unbiased manner to produce ...

Abstract	Single cell RNA sequencing technology has been dramatically changing how gene expression studies are performed. However, its use has been limited to identifying subtypes of cells by comparing cells' gene expression levels in an unbiased manner to produce a 2D plot (e.g., UMAP/tSNE). We developed a new method of placing cells in 2D space. This system, called vSPACE, shows a virtual spatial representation of scRNAseq data obtained from human articular cartilage by emulating the concept of spatial transcriptomics technology, but virtually. This virtual 2D plot presentation of human articular cartage cells generates several zonal distribution patterns, in one or multiple genes at a time, reveling patterns that scientists can appreciate as imputed spatial distribution patterns along the zonal axis. The discovered patterns are explainable and remarkably consistent across all six healthy doners despite their respectively different clinical variables (age and sex), suggesting the confidence of the discovered patterns.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.07.577817
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Article ; Online: Deep Semisupervised Transfer Learning for Fully Automated Whole-Body Tumor Quantification and Prognosis of Cancer on PET/CT.

Leung, Kevin H / Rowe, Steven P / Sadaghiani, Moe S / Leal, Jeffrey P / Mena, Esther / Choyke, Peter L / Du, Yong / Pomper, Martin G

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 4, Page(s) 643–650

Abstract: Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation and prognosis on PET/CT. ...

Abstract	Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation and prognosis on PET/CT.
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Melanoma ; Retrospective Studies ; Prostate-Specific Antigen ; Prognosis ; Prostatic Neoplasms ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/therapy ; Lymphoma ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/therapy ; Lung Neoplasms ; Machine Learning
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.267048
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Article ; Online: Nonlinear elasticity and short-range mechanical coupling govern the rate and symmetry of mouth opening in

Goel, Tapan / Adams, Ellen M / Bialas, April L / Tran, Cassidy M / Rowe, Trevor / Martin, Sara / Chandler, Maia / Schubert, Johanna / Diamond, Patrick H / Collins, Eva-Maria S

Proceedings. Biological sciences

2024 Volume 291, Issue 2017, Page(s) 20232123

Abstract: ... ...

Abstract	Hydra
MeSH term(s)	Animals ; Hydra/physiology ; Mouth/physiology ; Epithelium ; Biomechanical Phenomena ; Neurons
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.2123
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