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  1. AU=Sales-Peres Silvia Helena de Carvalho
  2. AU="Boyea, Beth Lincoln"
  3. AU=Martorell-Marugan Jordi
  4. AU="Serventi, Lisa"
  5. AU=O'Shea John J AU=O'Shea John J
  6. AU="Jiang, Dahai"
  7. AU="Sheng, Chu-Qiao"
  8. AU="Rodríguez, Fausto J."
  9. AU="Sadowski, Peter"
  10. AU="Noguera, Austin"
  11. AU="Daigneault, Tina"
  12. AU="Flores-Martínez, José Juan"
  13. AU="Gan, Yu-Ling"
  14. AU=Banno Asoka AU=Banno Asoka
  15. AU="Bertolin, Kalyne"
  16. AU="Rising, James A"
  17. AU="Jackson Voelkel"
  18. AU="Arias, Marisa"
  19. AU="Le, Uyen Nguyen Phuong"
  20. AU="Shim, Yun M"
  21. AU="Ngan, Hau Lan"
  22. AU="Shah, Fawad Ali"
  23. AU="Rodriguez Chinesta, J M"
  24. AU="Reddy, Avril"
  25. AU="Vachani, Anil"
  26. AU="Lofland, Gabriela"
  27. AU="Zou, Xiaoyan"
  28. AU="Norhafizah Bt Sahril"

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  1. Artikel ; Online: Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis.

    Sales-Peres, Silvia Helena de Carvalho / Azevedo-Silva, Lucas José de / Castilho, Ana Virginia Santana Sampaio / Castro, Marcelo Salmazo / Sales-Peres, André de Carvalho / Machado, Maria Aparecida de Andrade Moreira

    Brazilian oral research

    2023  Band 37, Seite(n) e031

    Abstract: This meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been ... ...

    Abstract This meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been conducted analyzing propolis's effects on COVID-19 and periodontitis. The study was conducted according to the PRISMA statement and registered in PROSPERO. Risk of Bias (RoB) assessment and meta-analysis of clinical studies were performed (Review Manager 5, Cochrane). The certainty of the evidence was assessed using GradePro (GDT). Studies have shown propolis flavonoids inhibit viral replication in several DNA and RNA viruses, including coronaviruses. Propolis components have an aminopeptidase inhibitor activity that can inhibit the main proteases of SARS viruses and seem to inhibit protein spikes, which are sites of most mutations in SARS-CoV strains. The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001). The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses. Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity. Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.
    Mesh-Begriff(e) Humans ; Propolis ; COVID-19 ; SARS-CoV-2 ; Periodontal Diseases ; Periodontitis/therapy
    Chemische Substanzen Propolis (9009-62-5)
    Sprache Englisch
    Erscheinungsdatum 2023-03-31
    Erscheinungsland Brazil
    Dokumenttyp Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2179332-3
    ISSN 1807-3107 ; 1806-8324 ; 1517-7491
    ISSN (online) 1807-3107
    ISSN 1806-8324 ; 1517-7491
    DOI 10.1590/1807-3107bor-2023.vol37.0031
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  2. Artikel ; Online: The changes on salivary flow rates, buffering capacity and chromogranin A levels in adults after bariatric surgery.

    Kogawa, Evelyn Mikaela / Melo, Fabíola Ferreira / Pires, Reuel Gomes / Caetano, Paulo César Candeia / de Lima Rodrigues, Jhonatan / Benito, Linconl Agudo Oliveira / da Silva, Izabel Cristina Rodrigues / de Castro Cantuária, Ana Paula / de Carvalho Sales-Peres, Silvia Helena

    Clinical oral investigations

    2024  Band 28, Heft 3, Seite(n) 159

    Abstract: Objectives: This study aimed to investigate changes in salivary flow rates, buffering capacity, and salivary chromogranin A (CHGA) levels in adults undergoing bariatric surgery (BS) compared with a non-obese control group.: Materials and methods: ... ...

    Abstract Objectives: This study aimed to investigate changes in salivary flow rates, buffering capacity, and salivary chromogranin A (CHGA) levels in adults undergoing bariatric surgery (BS) compared with a non-obese control group.
    Materials and methods: Salivary analyses were performed on 62 participants aged over 50 years, stratified into two groups matched for age and gender-individuals who had undergone bariatric surgery (BS) (n = 31) and a corresponding healthy control group (n = 31). Before saliva collection, participants completed a comprehensive 11-point visual numerical rating scale (NRS 0-10) xerostomia questionnaire, assessing subjective perceptions of two key aspects: dryness of the oral mucosa and resultant impact on oral functional ability. Three distinct saliva measurements were obtained: unstimulated whole saliva (UWS), stimulated whole saliva (SWS), and unstimulated upper labial saliva (ULS). The buffering capacity of unstimulated saliva was assessed using pH indicator strips, and concentrations of salivary Chromogranin A (CHGA) were quantified in stimulated saliva via enzyme-linked immunosorbent assay (ELISA).
    Results: After BS, more than 40% of BS group patients reported xerostomia, with 16.1% experiencing only mild symptoms without significant functional impact (p = 0.009). The prevalence of xerostomia and tongue dryness was higher in the BS group compared to the control group (p = 0.028 and p = 0.025, respectively). The comparative analysis unveiled no statistically significant differences in flow rates of unstimulated upper labial saliva (ULS), unstimulated whole saliva (UWS), and stimulated whole saliva (SWS) between the control group and patients who underwent bariatric surgery. However, in patients undergone BS with xerostomia, both ULS and UWS flow rates were significantly lower than in controls with xerostomia (p = 0.014 and p = 0.007, respectively). The buffering capacity was significantly lower in patients undergone BS than in controls (p = 0.009). No differences were found between groups regarding CHGA concentration and output values, nevertheless, higher values of CHGA concentrations were significantly correlated to lower flow rates.
    Conclusion: According to the results, this study suggests that individuals undergoing BS may exhibit altered salivary buffering capacity and reduced unstimulated salivary flows in the presence of xerostomia. Additionally, the findings suggest that elevated concentration of salivary CHGA might be associated, in part, with salivary gland hypofunction.
    Clinical relevance: The clinical significance of this study lies in highlighting the changes in salivary functions after BS. The identified salivary alterations might be attributed to adverse effects of BS such as vomiting, gastroesophageal reflux, and dehydration. Understanding these changes is crucial for healthcare professionals involved in the care of post-BS patients, as it sheds light on potential oral health challenges that may arise as a consequence of the surgical intervention. Monitoring and managing these salivary alterations can contribute to comprehensive patient care and enhance the overall postoperative experience for individuals undergoing BS.
    Mesh-Begriff(e) Humans ; Middle Aged ; Bariatric Surgery ; Chromogranin A ; Saliva ; Salivary Glands ; Xerostomia/complications
    Chemische Substanzen Chromogranin A
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-024-05551-3
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  3. Artikel ; Online: The Relationship between Professional Variables and Burnout Syndrome in Brazilian Dentists during the COVID-19 Pandemic.

    Castro, Marcelo Salmazo / Meira, Gabriela de Figueiredo / Mendes, Rharessa Gabrielly Ferreira / Castilho, Ana Virgínia Santana Sampaio / Trench, Leonardo de Aguiar / Segalla, Conrado Rodrigues / Vettore, Mario Vianna / Sales-Peres, Silvia Helena de Carvalho

    International journal of environmental research and public health

    2024  Band 21, Heft 4

    Abstract: Burnout syndrome (BS) is a highly prevalent occupational disease among dentists who, during the COVID-19 pandemic, have been at greater risk of contracting the disease, generating stress and distancing. The aim of this study was to assess the association ...

    Abstract Burnout syndrome (BS) is a highly prevalent occupational disease among dentists who, during the COVID-19 pandemic, have been at greater risk of contracting the disease, generating stress and distancing. The aim of this study was to assess the association of social conditions, professional factors and perceptions of COVID-19 with Burnout Syndrome. This was a cross-sectional study of 302 Brazilian dentists working in the clinical and private sectors. The professionals completed the Oldenburg Burnout Inventory online and answered sociodemographic and professional questions and questions related to their perception of the pandemic. Poisson regression with unadjusted and adjusted robust variance was used to estimate the association between burnout syndrome (dependent variable) and the independent variables. The presence of BS was strongly associated with age, training in a private institution, professionals who claimed to have sufficient protective knowledge and fear of being contaminated by SARS-CoV-2 during patient care (
    Mesh-Begriff(e) Humans ; COVID-19/psychology ; COVID-19/epidemiology ; Brazil/epidemiology ; Dentists/psychology ; Dentists/statistics & numerical data ; Male ; Female ; Adult ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Cross-Sectional Studies ; Middle Aged ; SARS-CoV-2 ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph21040435
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  4. Artikel ; Online: Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study.

    Sales-Peres, Silvia Helena de Carvalho / Houghton, Jack / Meira, Gabriela de Figueiredo / Moura-Grec, Patrícia Garcia de / Brienze, Sergio Luis Aparecido / Karim, Belkais Abuuasha / Carpenter, Guy Howard

    International journal of environmental research and public health

    2023  Band 20, Heft 7

    Abstract: This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/ ... ...

    Abstract This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m
    Mesh-Begriff(e) Humans ; Cohort Studies ; Adiponectin ; Bariatric Surgery ; Obesity, Morbid/surgery ; Weight Loss ; Gingival Diseases ; Albumins
    Chemische Substanzen Adiponectin ; Albumins
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20075261
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  5. Artikel ; Online: Tooth movement, orofacial pain, and leptin, interleukin-1β, and tumor necrosis factor-α levels in obese adolescents.

    Soares Bonato, Rafaela Carolina / Abel Mapengo, Marta Artemisa / de Azevedo-Silva, Lucas José / Janson, Guilherme / de Carvalho Sales-Peres, Silvia Helena

    The Angle orthodontist

    2021  Band 92, Heft 1, Seite(n) 95–100

    Abstract: Objectives: To evaluate tooth movement, orofacial pain, and leptin, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α cytokine levels in the gingival crevicular fluid (GCF) during orthodontic treatment in obese adolescents.: Materials and methods! ...

    Abstract Objectives: To evaluate tooth movement, orofacial pain, and leptin, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α cytokine levels in the gingival crevicular fluid (GCF) during orthodontic treatment in obese adolescents.
    Materials and methods: Participants included adolescent patients aged 12-18 years: group 1, obese (n = 30), and group 2, nonobese controls (n = 30). They were evaluated before (T0) and after 1 hour (T1), 24 hours (T2), and 1 week (T3) of fixed appliance bonding. Periodontal examination (T0), collection of GCF (T1, T2, T3), and evaluation of Little's irregularity index (T0, T3) were performed, and a visual analog scale was used to measure pain (T1, T2, T3). Evaluation of IL-1β, TNF-α, and leptin cytokines was performed using a Luminex assay. Mann-Whitney and t-tests were used for intergroup comparisons, and a generalized estimating equation and cluster analyses were used for comparisons among observation times (P < .05).
    Results: The obese group had a higher prevalence of probing depth of ≥4 mm and bleeding on probing. Orthodontic tooth movement was similar in both groups. Peak of pain was at T2 in both groups and was higher in the obese patients. TNF-α showed a slight increase at T1, followed by a gradual decrease at T2 and T3 in both groups. The obese group had a higher concentration of IL-1β before and during orthodontic treatment. There was no difference in tooth movement between obese and control patients during the first week of orthodontic treatment.
    Conclusions: Obese adolescents had a greater subjective report of orofacial pain after 24 hours of orthodontic treatment and higher concentrations of IL-1β proinflammatory cytokine before and during tooth movement as compared with nonobese control adolescents.
    Mesh-Begriff(e) Adolescent ; Facial Pain/etiology ; Gingival Crevicular Fluid/chemistry ; Humans ; Interleukin-1beta/analysis ; Leptin/analysis ; Pediatric Obesity ; Tooth Movement Techniques ; Tumor Necrosis Factor-alpha/analysis
    Chemische Substanzen Interleukin-1beta ; Leptin ; Tumor Necrosis Factor-alpha
    Sprache Englisch
    Erscheinungsdatum 2021-08-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390289-4
    ISSN 1945-7103 ; 0003-3219
    ISSN (online) 1945-7103
    ISSN 0003-3219
    DOI 10.2319/011321-44.1
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  6. Artikel ; Online: Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery

    Silvia Helena de Carvalho Sales-Peres / Jack Houghton / Gabriela de Figueiredo Meira / Patrícia Garcia de Moura-Grec / Sergio Luis Aparecido Brienze / Belkais Abuuasha Karim / Guy Howard Carpenter

    International Journal of Environmental Research and Public Health, Vol 20, Iss 5261, p

    A Cohort Study

    2023  Band 5261

    Abstract: This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m 2 ) who ... ...

    Abstract This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m 2 ) who underwent bariatric surgery Roux-en-Y gastric bypass (RYGB) in System Health Public in Brazil. Data on demographic and anthropometric measures were extracted from medical records preoperatively and 6 and 12 months post-surgery. The variables assessed were: probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and stimulated whole-mouth saliva. In this study, saliva samples were analyzed by electrophoresis and immunoblotting. The ELISA kit was used to measure the MMP8 levels to determine potential markers for obesity. Adiponectin and albumin levels were also evaluated. Weight loss was associated with significant changes in patients’ periodontal clinical data. Although 7 out of 10 periodontal patients showed an increase in salivary adiponectin levels after root planning treatment, when analyzed by Western blotting, the increase was not statistically significant (21.1 ± 4.8 to 26.3 ± 9.4 arbitrary units, p > 0.99). There was no correlation between albumin levels and salivary adiponectin pre-surgery, nor 6 months or 12 months after surgery. Weight loss was not improved by low-grade inflammation in bariatric patients, since albumin levels were similar between periods. Periodontitis is an inflammatory disease that is modulated by several factors, among which adiponectin plays an important role for the treatment of periodontal disease.
    Schlagwörter salivary biomarkers ; periodontal disease ; obesity ; adiponectin ; albumin ; Medicine ; R
    Thema/Rubrik (Code) 616 ; 610
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  7. Artikel: Coronavirus (SARS-CoV-2) and the risk of obesity for critically illness and ICU admitted: Meta-analysis of the epidemiological evidence.

    Sales-Peres, Silvia Helena de Carvalho / de Azevedo-Silva, Lucas José / Bonato, Rafaela Carolina Soares / Sales-Peres, Matheus de Carvalho / Pinto, Ana Carolina da Silvia / Santiago Junior, Joel Ferreira

    Obesity research & clinical practice

    2020  Band 14, Heft 5, Seite(n) 389–397

    Abstract: Objectives: To investigate the relationship between coronavirus disease 2019 (COVID-19) and obesity in critically ill patients admitted to the intensive care unit (ICU).: Methods: We systematically searched PubMed, SCOPUS, Embase, LILACS, and Web of ... ...

    Abstract Objectives: To investigate the relationship between coronavirus disease 2019 (COVID-19) and obesity in critically ill patients admitted to the intensive care unit (ICU).
    Methods: We systematically searched PubMed, SCOPUS, Embase, LILACS, and Web of Science for studies published up to April 27, 2020. The outcome of interest was composite poor outcome, comprising mortality and severe COVID-19. We used a standardized data extraction form to collect information from published reports of eligible studies. Heterogeneity and publication bias were assessed using I
    Results: Nine studies including 6577 patients were selected for evaluation. The COVID-19 patients were 59.80% male and had comorbidities such as hypertension (51.51%), diabetes (30.3%), cardiovascular disease (16.66%), lung disease (15.99%), renal disease (7.49%), cancer (5.07%), and immunosuppression (1.8%). For patients with severe complications, the overall pooled event rates were 56.2% (random; 95% CI: 35.3-75.1; p = 0.015; I
    Discussion: This systematic review indicated the relationship between obesity, ICU admission, severe COVID-19, and disease progression in patients with COVID-19. Obese patients with hypertension, type 2 diabetes, smoking habit, lung disease, and/or cardiovascular disease should be cared for with increased attention.
    Mesh-Begriff(e) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Critical Illness ; Female ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity/virology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2274031-4
    ISSN 1878-0318 ; 1871-403X
    ISSN (online) 1878-0318
    ISSN 1871-403X
    DOI 10.1016/j.orcp.2020.07.007
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  8. Artikel ; Online: Coronavirus (SARS-CoV-2) and the risk of obesity for critically illness and ICU admitted

    Sales-Peres, Silvia Helena de Carvalho / de Azevedo-Silva, Lucas José / Bonato, Rafaela Carolina Soares / Sales-Peres, Matheus de Carvalho / Pinto, Ana Carolina da Silvia / Santiago Junior, Joel Ferreira

    Obesity Research & Clinical Practice

    Meta-analysis of the epidemiological evidence

    2020  Band 14, Heft 5, Seite(n) 389–397

    Schlagwörter Nutrition and Dietetics ; Endocrinology, Diabetes and Metabolism ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2274031-4
    ISSN 1878-0318 ; 1871-403X
    ISSN (online) 1878-0318
    ISSN 1871-403X
    DOI 10.1016/j.orcp.2020.07.007
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  9. Artikel ; Online: Coronavirus (SARS-CoV-2) and the Risk of Obesity for Critically Illness and ICU Admitted

    Sales-Peres, Silvia Helena de / de Azevedo-Silva, Lucas José / Soares Bonato, Rafaela Carolina / de Carvalho Sales-Peres, Matheus / da Silvia Pinto, Ana Carolina / Santiago Junior, Joel Ferreira

    SSRN Electronic Journal ; ISSN 1556-5068

    Systematic Review and Meta-Analysis of the Epidemiological Evidence

    2020  

    Schlagwörter covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.2139/ssrn.3612053
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  10. Artikel: Periodontal status and quality of life in pregnant women with both overweight/obesity and hypertension: A cross-sectional study.

    Foratori-Junior, Gerson-Aparecido / Jesuino, Bruno-Gualtieri / Castilho, Ana-Virgínia-Santana-Sampaio / Sales-Peres, Silvia-Helena-de Carvalho

    Journal of clinical and experimental dentistry

    2021  Band 13, Heft 11, Seite(n) e1140–e1146

    Abstract: Background: The aim of this study was to assess the periodontal condition and quality of life of pregnant women affected with both overweight/obesity and arterial hypertension.: Material and methods: Pregnant women were dived into three groups: with ... ...

    Abstract Background: The aim of this study was to assess the periodontal condition and quality of life of pregnant women affected with both overweight/obesity and arterial hypertension.
    Material and methods: Pregnant women were dived into three groups: with overweight/obesity and hypertension (G1 = 23), with overweight/obesity without hypertension (G2 = 31) and with normal BMI and without hypertension (G3 = 38). They were evaluated regarding: contextual variables (age, socioeconomic level and anthropometric parameters); periodontal status; and quality of life (adapted version of Oral Health Impact Profile - OHIP-14). ANOVA, Kruskal-Wallis, chi-square and binary logistic regression model were adopted (
    Results: There were no intergroup differences for age (
    Conclusions: In conclusion, maternal excessive weight is associated with periodontitis during pregnancy. Moreover, the presence of hypertension in overweight pregnant women seems to be determinant to negatively influence their quality of life, resulting in physical, psychological and social damages.
    Sprache Englisch
    Erscheinungsdatum 2021-11-01
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.58789
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