Article ; Online: Soft Synthetic Cells with Mobile Membrane Ligands for Ex Vivo Expansion of Therapy-Relevant T Cell Phenotypes.
Small (Weinheim an der Bergstrasse, Germany)
2024 , Page(s) e2401844
Abstract: The expansion of T cells ex vivo is crucial for effective immunotherapy but currently limited by a lack of expansion approaches that closely mimic in vivo T cell activation. Taking inspiration from bottom-up synthetic biology, a new synthetic cell ... ...
Abstract | The expansion of T cells ex vivo is crucial for effective immunotherapy but currently limited by a lack of expansion approaches that closely mimic in vivo T cell activation. Taking inspiration from bottom-up synthetic biology, a new synthetic cell technology is introduced based on dispersed liquid-liquid phase-separated droplet-supported lipid bilayers (dsLBs) with tunable biochemical and biophysical characteristics, as artificial antigen presenting cells (aAPCs) for ex vivo T cell expansion. These findings obtained with the dsLB technology reveal three key insights: first, introducing laterally mobile stimulatory ligands on soft aAPCs promotes expansion of IL-4/IL-10 secreting regulatory CD8 |
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Language | English |
Publishing date | 2024-05-15 |
Publishing country | Germany |
Document type | Journal Article |
ZDB-ID | 2168935-0 |
ISSN | 1613-6829 ; 1613-6810 |
ISSN (online) | 1613-6829 |
ISSN | 1613-6810 |
DOI | 10.1002/smll.202401844 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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