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  1. Article ; Online: Authors' response.

    Shang, Ren / Gao, Limin

    Journal of the American Dental Association (1939)

    2021  Volume 152, Issue 8, Page(s) 587

    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2021.06.006
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    Ul III Zs.72: Show issues Location:
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  2. Article ; Online: Conformation-Activity Mechanism of Alcalase Hydrolysis for Reducing In Vitro Allergenicity of Instant Soy Milk Powder.

    Ding, Jie / Qi, Libo / Zhong, Limin / Shang, Shan / Zhu, Chunyan / Lin, Songyi

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 18, Page(s) 10627–10639

    Abstract: Effective reduction of the allergenicity of instant soy milk powder (ISMP) is practically valuable for expanding its applications. This study optimized the enzymolysis technology of ISMP using single-factor experiments and response surface methodology, ... ...

    Abstract Effective reduction of the allergenicity of instant soy milk powder (ISMP) is practically valuable for expanding its applications. This study optimized the enzymolysis technology of ISMP using single-factor experiments and response surface methodology, combined serological analysis, cellular immunological models, bioinformatics tools, and multiple spectroscopy techniques to investigate the effects of alcalase hydrolysis on allergenicity, spatial conformation, and linear epitopes of ISMP. Under the optimal process, special IgE and IgG1 binding abilities and allergenic activity to induce cell degranulation of alcalase-hydrolyzed ISMP were reduced by (64.72 ± 1.76)%, (56.79 ± 3.72)%, and (73.3 ± 1.19)%, respectively (
    MeSH term(s) Subtilisins/chemistry ; Subtilisins/immunology ; Hydrolysis ; Humans ; Soybean Proteins/chemistry ; Soybean Proteins/immunology ; Allergens/immunology ; Allergens/chemistry ; Soy Milk/chemistry ; Powders/chemistry ; Immunoglobulin E/immunology ; Immunoglobulin G/immunology ; Globulins/chemistry ; Globulins/immunology ; Food Hypersensitivity/prevention & control ; Food Hypersensitivity/immunology ; Structure-Activity Relationship
    Chemical Substances Subtilisins (EC 3.4.21.-) ; Soybean Proteins ; Allergens ; Powders ; Immunoglobulin E (37341-29-0) ; Immunoglobulin G ; Globulins ; glycinin (9007-93-6)
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.4c00767
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    Zs.A 1172: Show issues Location:
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  3. Article ; Online: PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration.

    Guo, Jiankun / Wang, Hailong / Huang, Changhua / Lai, Caihong / Shang, Wenli / Luo, Shiwen / Chen, Limin

    Biochimica et biophysica acta. Molecular cell research

    2024  Volume 1871, Issue 5, Page(s) 119744

    Abstract: Background: Lung squamous cell carcinoma (LUSC) is associated with high mortality and has limited therapeutic treatment options. Plasminogen activator urokinase (PLAU) plays important roles in tumor cell malignancy. However, the oncogenic role of PLAU ... ...

    Abstract Background: Lung squamous cell carcinoma (LUSC) is associated with high mortality and has limited therapeutic treatment options. Plasminogen activator urokinase (PLAU) plays important roles in tumor cell malignancy. However, the oncogenic role of PLAU in the progression of LUSC remains unknown. GATA-binding factor 6 (GATA6), a key regulator of lung development, inhibits LUSC cell proliferation and migration, but the underlying regulatory mechanism remains to be further explored. Moreover, the regulatory effect of GATA6 on PLAU expression has not been reported. The aim of this study was to identify the role of PLAU and the transcriptional inhibition mechanism of GATA6 on PLAU expression in LUSC.
    Methods: To identify the potential target genes regulated by GATA6, differentially expressed genes (DEGs) obtained from GEO datasets analysis and RNA-seq experiment were subjected to Venn analysis and correlation heatmap analysis. The transcriptional regulatory effects of GATA6 on PLAU expression were detected by real-time PCR, immunoblotting, and dual-luciferase reporter assays. The oncogenic effects of PLAU on LUSC cell proliferation and migration were evaluated by EdU incorporation, Matrigel 3D culture and Transwell assays. PLAU expression was detected in tissue microarray of LUSC via immunohistochemistry (IHC) assay. To determine prognostic factors for prognosis of LUSC patients, the clinicopathological characteristics and PLAU expression were subjected to univariate Cox regression analysis.
    Results: PLAU overexpression promoted LUSC cell proliferation and migration. PLAU is overexpressed in LUSC tissues compared with normal tissues. Consistently, high PLAU expression, which acts as an independent risk factor, is associated with poor prognosis of LUSC patients. Furthermore, the expression of PLAU is transcriptionally regulated by GATA6.
    Conclusion: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.
    Language English
    Publishing date 2024-05-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2024.119744
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  4. Article ; Online: Impact of hyperglycemia on the rate of implant failure and peri-implant parameters in patients with type 2 diabetes mellitus: Systematic review and meta-analysis.

    Shang, Ren / Gao, Limin

    Journal of the American Dental Association (1939)

    2021  Volume 152, Issue 3, Page(s) 189–201.e1

    Abstract: Background: The impact of hyperglycemia on dental implant therapy remains unclear. In this systematic review and meta-analysis, the authors compared the rates of implant failure and peri-implant bleeding on probing (BOP), probing depth (PD), and peri- ... ...

    Abstract Background: The impact of hyperglycemia on dental implant therapy remains unclear. In this systematic review and meta-analysis, the authors compared the rates of implant failure and peri-implant bleeding on probing (BOP), probing depth (PD), and peri-implant bone loss (PIBL) among patients with type 2 diabetes mellitus and nondiabetic patients. The authors performed subgroup analyses based on glycemic level to evaluate whether patients with higher glycemic levels were more prone to peri-implant inflammation.
    Type of studies reviewed: The authors searched 4 databases for original clinical studies. Studies in which the researchers provided information on the rate of implant failure or peri-implant parameters were included.
    Results: Nine clinical studies were identified on the basis of the inclusion criteria. No significant differences were found in rates of implant failure (P = .46) and PD (P = .1) between diabetic and nondiabetic patients. Significant differences in BOP (P < .00001) and PIBL (P = .02), favoring nondiabetic patients, were observed. Results of subgroup analyses indicated that the increase in glycemic level did not significantly influence BOP, PD, and PIBL values among diabetic patients.
    Conclusions and practical implications: Patients with type 2 diabetes mellitus seem to be able to achieve a rate of implant survival similar to that of healthy patients. Regarding peri-implant parameters, BOP and PIBL were higher in patients with type 2 diabetes mellitus, indicating that hyperglycemia is an important risk factor for peri-implant inflammation. No association was found between peri-implant parameters and glycemic level among patients with type 2 diabetes mellitus, providing oral hygiene was strictly maintained.
    MeSH term(s) Alveolar Bone Loss ; Dental Implants ; Dental Plaque Index ; Diabetes Mellitus, Type 2/complications ; Humans ; Hyperglycemia/etiology ; Peri-Implantitis ; Periodontal Index
    Chemical Substances Dental Implants
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2020.11.015
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  5. Article: Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

    Wu, Shang / Zhang, Limin / Wang, Weizhi

    Analytical chemistry. 2022 July 11, v. 94, no. 33

    2022  

    Abstract: A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows ... ...

    Abstract A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.
    Keywords COVID-19 infection ; Pseudovirus ; Severe acute respiratory syndrome coronavirus 2 ; analytical chemistry ; peptide libraries
    Language English
    Dates of publication 2022-0711
    Size p. 11464-11469.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02223
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer's Disease.

    Ma, Limin / Wang, Fengyu / Chen, Shuai / Wang, Shenghui / Wang, Zhenzhen / Xia, Mingrong / Li, Yongli / Ma, Huimin / Shang, Junkui / Zhang, Jiewen

    Neuromolecular medicine

    2024  Volume 26, Issue 1, Page(s) 6

    Abstract: Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant inherited AD. ... ...

    Abstract Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant inherited AD. This study aimed to demonstrate a Chinese early-onset AD pedigree presenting as progressive memory impairment, apraxia, visual-spatial disorders, psychobehavioral disorders, and personality changes with a novel APP gene mutation. The family contains four patients, three carries and three normal family members. The proband underwent brain magnetic resonance imaging (MRI),
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Amyloid beta-Protein Precursor/genetics ; Fluorodeoxyglucose F18 ; Mutation ; China ; Presenilin-1/genetics ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Ethylene Glycols
    Chemical Substances florbetapir (6867Q6IKOD) ; Amyloid beta-Protein Precursor ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Presenilin-1 ; Amyloid beta-Peptides ; Aniline Compounds ; Ethylene Glycols
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2077809-0
    ISSN 1559-1174 ; 1535-1084
    ISSN (online) 1559-1174
    ISSN 1535-1084
    DOI 10.1007/s12017-023-08770-1
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    Zs.A 5818: Show issues Location:
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  7. Article ; Online: Spontaneously ruptured multilocular cystic nephroma in an infant.

    Xu, Ling / Wang, Limin / Tian, Xiangying / Gai, Yuanyuan / Shang, Ning

    Journal of clinical ultrasound : JCU

    2022  

    Abstract: We present the case of a 10-month-old girl with spontaneously ruptured cystic nephroma with a 1-week-old abdominal mass and a 1-day history of marked abdominal distension. The tumor presented as gourd-shaped, cystic solid mass in the right kidney with ... ...

    Abstract We present the case of a 10-month-old girl with spontaneously ruptured cystic nephroma with a 1-week-old abdominal mass and a 1-day history of marked abdominal distension. The tumor presented as gourd-shaped, cystic solid mass in the right kidney with fluid collection. The tumor was successfully removed by urgent surgery. The girl remained in good condition throughout six-month follow-up after.
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 189393-2
    ISSN 1097-0096 ; 0091-2751
    ISSN (online) 1097-0096
    ISSN 0091-2751
    DOI 10.1002/jcu.23267
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    Zs.A 1186: Show issues Location:
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  8. Article ; Online: Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain.

    Wu, Shang / Zhang, Limin / Wang, Weizhi

    Analytical chemistry

    2022  Volume 94, Issue 33, Page(s) 11464–11469

    Abstract: A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows ... ...

    Abstract A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.
    MeSH term(s) Humans ; Peptides/chemistry ; Prions ; Protein Binding ; Protein Conformation, alpha-Helical ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; COVID-19 Drug Treatment
    Chemical Substances Peptides ; Prions ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02223
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    Zs.A 4033: Show issues Location:
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  9. Article ; Online: Selective CD47 targeting with a bispecific antibody.

    Ferlin, Walter / Masternak, Krzysztof / Shang, Limin

    Cancer immunology, immunotherapy : CII

    2021  Volume 70, Issue 4, Page(s) 1161–1162

    MeSH term(s) Animals ; Antibodies, Bispecific/immunology ; Antibodies, Bispecific/pharmacology ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; CD47 Antigen/antagonists & inhibitors ; CD47 Antigen/immunology ; CD47 Antigen/metabolism ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy/methods ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy
    Chemical Substances Antibodies, Bispecific ; B7-H1 Antigen ; CD47 Antigen
    Language English
    Publishing date 2021-01-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-020-02812-4
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    Zs.A 1237: Show issues Location:
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  10. Article ; Online: Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.

    Shang, Limin / Yu, Yixin / Jiang, Yujie / Liu, Xinyu / Sui, Ning / Yang, Dongqin / Zhu, Zhiling

    ACS nano

    2023  Volume 17, Issue 16, Page(s) 15962–15977

    Abstract: Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by the diversity and synergy of drug ... ...

    Abstract Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by the diversity and synergy of drug functions as well as the DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine and ultrasmall gold nanoparticles and Cu
    MeSH term(s) Humans ; Hydrogels/pharmacology ; Blood Glucose ; Gold ; Metal Nanoparticles/therapeutic use ; Diabetes Mellitus ; Wound Healing ; Peroxidase ; Superoxide Dismutase ; Antioxidants ; Glucose Oxidase
    Chemical Substances Hydrogels ; Blood Glucose ; Gold (7440-57-5) ; Peroxidase (EC 1.11.1.7) ; Superoxide Dismutase (EC 1.15.1.1) ; Antioxidants ; Glucose Oxidase (EC 1.1.3.4)
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c04134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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