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  1. Buch ; Online ; E-Book: Inequalities in respiratory health

    Sinha, Ian P.

    (ERS monograph series ; number 99, March 2023)

    2023  

    Abstract: If we are to address deeply ingrained health inequalities, we need to reflect on what has driven them, and critically review the approaches that do and do not work. This Monograph brings together a collection of state-of-the-art articles, discussing the ... ...

    Verfasserangabe edited by Ian P. Sinha [und 3 weiteren]
    Serientitel ERS monograph series ; number 99, March 2023
    ERS monograph
    Überordnung ERS monograph
    Abstract If we are to address deeply ingrained health inequalities, we need to reflect on what has driven them, and critically review the approaches that do and do not work. This Monograph brings together a collection of state-of-the-art articles, discussing the drivers and consequences of respiratory inequality.

    Front cover -- Title page -- Contents -- Preface -- Guest Editor biographies -- Introduction -- List of abbreviations -- Understanding the mechanisms of poverty and respiratory ill health -- Chapter 1. How to read a paper about inequality in respiratory disease: basic epidemiological principles and how inequalities are measured -- Chapter 2. What causes poverty and how does this contribute to respiratory inequality? -- Chapter 3. Ethnic, racial and migrant inequalities inrespiratory health -- Chapter 4. Inequalities in respiratory health based on sex and gender -- Chapter 5. Air pollution and respiratory inequality: lessons from high-income countries -- Chapter 6. Food insecurity and respiratory ill health -- Chapter 7. Housing and respiratory health: exposures, health effects and interventions -- Chapter 8. Tobacco, novel tobacco and nicotine products, and respiratory health -- Chapter 9. Work and respiratory health: lessons from occupational lung disease -- Chapter 10. Antenatal determinants of child lung development -- Inequalities in disease and ill health: what are we observing, and what are the mechanisms? -- Chapter 11. Inequalities in cystic fibrosis -- Chapter 12. Health inequality and COPD -- Chapter 13. Inequalities in asthma -- Chapter 14. Lung cancer and inequalities in access to multidisciplinary lung cancer services -- Chapter 15. Societal drivers of antimicrobial resistance -- Chapter 16. Inclusion health: respiratory health among people affected by social exclusion -- A global view of respiratory inequalities and approaches to solve these -- Chapter 17. Preventable deaths from respiratory diseases in children in low- and middle-income countries -- Chapter 18. Air quality in low- and middle-income countries: what is the impact on respiratory morbidity and mortality? -- Chapter 19. Global inequalities in tuberculosis.
    Schlagwörter Electronic books
    Sprache Englisch
    Umfang 1 Online-Ressource (xiii, 248 Seiten), Illustrationen
    Verlag European Respiratory Society
    Erscheinungsort Sheffield
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030020420
    ISBN 978-1-84984-158-0 ; 9781849841573 ; 1-84984-158-6 ; 1849841578
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online ; E-Book: Respiratory diseases of the newborn infant

    Hurst, John R. / Sinha, Ian P.

    (ERS monograph ; number 92)

    2021  

    Verfasserangabe edited by Ian P. Sinha [und 3 weitere] ; editor-in-chief John R. Hurst
    Serientitel ERS monograph ; number 92
    Überordnung
    Schlagwörter Electronic books
    Sprache Englisch
    Umfang 1 Online-Ressource (xi, 371 Seiten), Illustrationen
    Verlag European Respiratory Society
    Erscheinungsort Sheffield
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021009054
    ISBN 978-1-84984-138-2 ; 9781849841368 ; 1-84984-138-1 ; 1849841365
    DOI 10.1183/2312508X.10015620
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Evidence suggests dexamethasone is a better choice than prednisolone for acute asthma attacks in children.

    Sinha, Ian P

    Archives of disease in childhood

    2021  

    Sprache Englisch
    Erscheinungsdatum 2021-05-24
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-321499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Lockdowns don't kill women, abusive men do.

    Sinha, Ian

    BMJ (Clinical research ed.)

    2020  Band 371, Seite(n) m4795

    Mesh-Begriff(e) COVID-19 ; Domestic Violence ; Female ; Humans ; Male ; Public Health ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2020-12-15
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m4795
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Risk of COVID-19 hospital admission among children with asthma.

    Harwood, Rachel / Sinha, Ian P

    The Lancet. Respiratory medicine

    2021  Band 10, Heft 2, Seite(n) 128–130

    Mesh-Begriff(e) Asthma ; COVID-19 ; Child ; Hospitalization ; Hospitals ; Humans ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-11-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00509-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Developing and assessing health information technologies: opportunities and challenges.

    Neame, Matthew Thomas / Cresswell, Kathrin / Sinha, Ian / Hawcutt, Daniel B

    Archives of disease in childhood. Education and practice edition

    2023  Band 108, Heft 5, Seite(n) 369–372

    Mesh-Begriff(e) Humans ; Medical Informatics
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2022-324521
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis.

    Aslam, Aisha A / Sinha, Ian P / Southern, Kevin W

    The Cochrane database of systematic reviews

    2023  Band 3, Seite(n) CD012040

    Abstract: Background: Cystic fibrosis (CF) is a common, life-shortening, genetic disorder in populations of Northern European descent caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator ( ...

    Abstract Background: Cystic fibrosis (CF) is a common, life-shortening, genetic disorder in populations of Northern European descent caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces, and the mutation most notably affects the airways. In the lungs of people with CF, the defective protein compromises mucociliary clearance and makes the airway prone to chronic infection and inflammation, damaging the structure of the airways and eventually leading to respiratory failure. In addition, abnormalities in the truncated CFTR protein lead to other systemic complications, including malnutrition, diabetes and subfertility. Five classes of mutation have been described, depending on the impact of the mutation on the processing of the CFTR protein in the cell. In class I mutations, premature termination codons prevent the production of any functional protein, resulting in severe CF. Therapies targeting class I mutations aim to enable the normal cellular mechanism to read through the mutation, potentially restoring the production of the CFTR protein. This could, in turn, normalise salt transport in the cells and decrease the chronic infection and inflammation that characterises lung disease in people with CF. This is an update of a previously published review.
    Objectives: To evaluate the benefits and harms of ataluren and similar compounds on clinically important outcomes in people with CF with class I mutations (premature termination codons).
    Search methods: We searched the Cochrane Cystic Fibrosis Trials Register, which is compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles. The last search of the Cochrane Cystic Fibrosis Trials Register was conducted on 7 March 2022. We searched clinical trial registries maintained by the European Medicines Agency, the US National Institutes of Health and the World Health Organization. The last search of the clinical trials registries was conducted on 4 October 2022.
    Selection criteria: Randomised controlled trials (RCTs) of parallel design comparing ataluren and similar compounds (specific therapies for class I mutations) with placebo in people with CF who have at least one class I mutation.
    Data collection and analysis: For the included trials, the review authors independently extracted data, assessed the risk of bias and evaluated the certainty of the evidence using GRADE; trial authors were contacted for additional data.
    Main results: Our searches identified 56 references to 20 trials; of these, 18 trials were excluded. Both the included parallel RCTs compared ataluren to placebo for 48 weeks in 517 participants (males and females; age range six to 53 years) with CF who had at least one nonsense mutation (a type of class I mutation). The certainty of evidence and risk of bias assessments for the trials were moderate overall. Random sequence generation, allocation concealment and blinding of trial personnel were well documented; participant blinding was less clear. Some participant data were excluded from the analysis in one trial that also had a high risk of bias for selective outcome reporting. PTC Therapeutics Incorporated sponsored both trials with grant support from the Cystic Fibrosis Foundation, the US Food and Drug Administration's Office of Orphan Products Development and the National Institutes of Health. The trials reported no difference between treatment groups in terms of quality of life, and no improvement in respiratory function measures. Ataluren was associated with a higher rate of episodes of renal impairment (risk ratio 12.81, 95% confidence interval 2.46 to 66.65; P = 0.002; I
    Mesh-Begriff(e) Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Aminoglycosides ; Anti-Bacterial Agents ; Codon, Nonsense ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Mutation ; Persistent Infection
    Chemische Substanzen Aminoglycosides ; Anti-Bacterial Agents ; ataluren (K16AME9I3V) ; Codon, Nonsense ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Sprache Englisch
    Erscheinungsdatum 2023-03-03
    Erscheinungsland England
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD012040.pub3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The Impact of Malnutrition on the Developing Lung and Long-Term Lung Health: A Narrative Review of Global Literature.

    Tharumakunarajah, Ramiyya / Lee, Alice / Hawcutt, Daniel B / Harman, Nicola L / Sinha, Ian P

    Pulmonary therapy

    2024  

    Abstract: Worldwide, over 2 billion children under the age of 5 experience stunting, wasting, or are underweight. Malnutrition contributes to 45% of all deaths in this age group (approximately 3.1 million deaths) [1]. Poverty, food insecurity, suboptimal feeding ... ...

    Abstract Worldwide, over 2 billion children under the age of 5 experience stunting, wasting, or are underweight. Malnutrition contributes to 45% of all deaths in this age group (approximately 3.1 million deaths) [1]. Poverty, food insecurity, suboptimal feeding practices, climate change, and conflict are all contributing factors. Malnutrition causes significant respiratory problems, including increased risk of respiratory infections, impaired lung function, and increased risk of subsequent adult respiratory disease, including asthma, COPD, and lung cancer. Childhood malnutrition not only has serious consequences for children's health but it also has numerous consequences on wellbeing and educational attainment. Childhood malnutrition is a complex and multifaceted problem. However, by understanding and addressing the underlying causes, and investing in prevention and treatment programs, it is possible to maximize children's health and wellbeing on a global scale. This narrative review will focus on the impact of childhood malnutrition on lung development, the consequent respiratory disease, and what actions can be taken to reduce the burden of malnutrition on lung health.
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2364-1746
    ISSN (online) 2364-1746
    DOI 10.1007/s41030-024-00257-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The impact of poor housing and indoor air quality on respiratory health in children.

    Holden, Karl A / Lee, Alice R / Hawcutt, Daniel B / Sinha, Ian P

    Breathe (Sheffield, England)

    2023  Band 19, Heft 2, Seite(n) 230058

    Abstract: It is becoming increasingly apparent that poor housing quality affects indoor air quality, significantly impacting on respiratory health in children and young people. Exposure to damp and/or mould in the home, cold homes and the presence of pests and ... ...

    Abstract It is becoming increasingly apparent that poor housing quality affects indoor air quality, significantly impacting on respiratory health in children and young people. Exposure to damp and/or mould in the home, cold homes and the presence of pests and pollutants all have a significant detrimental impact on child respiratory health. There is a complex relationship between features of poor-quality housing, such as being in a state of disrepair, poor ventilation, overcrowding and being cold, that favour an environment resulting in poor indoor air quality. Children living in rented (private or public) housing are more likely to come from lower-income backgrounds and are most at risk of living in substandard housing posing a serious threat to respiratory health. Children have the right to safe and adequate housing, and research has shown that either rehousing or making modifications to poor-quality housing to improve indoor air quality results in improved respiratory health. Urgent action is needed to address this threat to health. All stakeholders should understand the relationship between poor-quality housing and respiratory health in children and act, working with families, to redress this modifiable risk factor.
    Educational aims: The reader should understand how housing quality and indoor air quality affect respiratory health in children.The reader should understand which children are at most risk of living in poor-quality housing.The reader should understand what policy recommendations have been made and what actions need to be undertaken to improve housing quality and respiratory health in children and young people.
    Sprache Englisch
    Erscheinungsdatum 2023-08-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0058-2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Comparing Naturalistic Mental Health Expressions on Student Loan Debts Using Reddit and Twitter.

    Sinha, Gaurav R / Larrison, Christopher R / Brooks, Ian / Kursuncu, Ugur

    Journal of evidence-based social work (2019)

    2023  Band 20, Heft 5, Seite(n) 727–742

    Abstract: Purpose: The primary objective of this study was to identify patterns in users' naturalistic expressions on student loans on two social media platforms. The secondary objective was to examine how these patterns, sentiments, and emotions associated with ... ...

    Abstract Purpose: The primary objective of this study was to identify patterns in users' naturalistic expressions on student loans on two social media platforms. The secondary objective was to examine how these patterns, sentiments, and emotions associated with student loans differ in user posts indicating mental illness.
    Material and method: Data for this study were collected from Reddit and Twitter (2009-2020,
    Results: Results suggested 50 topics in reddit finance and 40 each in reddit mental health communities and Twitter. Statistically significant associations were found between mental illness statuses and sentiments and emotions. Posts expressing mental illness showed more negative sentiments and were more likely to express sadness and fear.
    Discussion and conclusion: Patterns in social media discussions indicate both academic and non-academic consequences of having student debt, including users' desire to know more about their debts. Interventions should address the skill and information gaps between what is desired by the borrowers and what is offered to them in understanding and managing their debts. Cognitive burden created by student debts manifest itself on social media and can be used as an important marker to develop a nuanced understanding of people's expressions on a variety of socioeconomic issues. Higher volumes of negative sentiments and emotions of sadness, fear, and anger warrant immediate attention of policymakers and practitioners to reduce the cognitive burden of student debts.
    Mesh-Begriff(e) Humans ; Mental Health ; Social Media ; Emotions ; Attitude ; Training Support
    Sprache Englisch
    Erscheinungsdatum 2023-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2640-8074
    ISSN (online) 2640-8074
    DOI 10.1080/26408066.2023.2202668
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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