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  1. AU=Suhail Shanzay
  2. AU="Masum, Hassan"
  3. AU="Del Águila, Javier García"
  4. AU="Balian, Dikran Raffi"
  5. AU="Starr, Megan M"
  6. AU=Rajapaksa Shabna
  7. AU="Mohammed Aly Abdou" AU="Mohammed Aly Abdou"
  8. AU=Cooper Isabella D
  9. AU="Luis Rivera-Armenta, Jose"
  10. AU="Zahid Shaikh"
  11. AU="Scovil, Carol"
  12. AU="Grove, Nico"
  13. AU="McGuire, K J"
  14. AU="Martin, Bianca Aparecida"
  15. AU="Hampton, Joshua Trae"
  16. AU=Thesen Thomas
  17. AU=Oliveira Giuliano da Paz
  18. AU="García, Patricia J"
  19. AU="Hosseinpanah, Farhad"
  20. AU="Mayuni, Grace"
  21. AU="Volkova, Yulia L"
  22. AU="Dauwerse, Sierk"

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  1. Artikel ; Online: Patient Understanding of Chemotherapy and Goals of Care as Provided by Different Care Team Members.

    Suhail, Shanzay / Basu, Sandeep / Batoo, Sameer A / Al-Hattab, Eyad S / Kanj Ahmed, Ola / Eidahl, Barbara J / Okuno, Scott H

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2023  Band 38, Heft 4, Seite(n) 1215–1223

    Abstract: Chemotherapy can be challenging and overwhelming for patients, but when patients are knowledgeable about chemotherapy, their comfort level, overall satisfaction, and coping improve. It is currently unknown whether patients prefer information about ... ...

    Abstract Chemotherapy can be challenging and overwhelming for patients, but when patients are knowledgeable about chemotherapy, their comfort level, overall satisfaction, and coping improve. It is currently unknown whether patients prefer information about chemotherapy to be provided by specific care team members and whether demographic characteristics affect learning preferences. We developed a 31-question questionnaire that asked patients when chemotherapy information was discussed and who they wanted that information to come from. The questionnaire was given to 50 patients who had completed 1 cycle of chemotherapy. Patients were evenly distributed among age categories of 45 to 64 years, 65 to 74 years, and 75 years or older. Thirty participants (60%) were women, 33 (66%) had high school degrees, and 23 (46%) were receiving their first chemotherapy regimen. Sixty percent of patients best understood goals of care from oncologists, 70% wanted goals of care to come from oncologists, and 61% best understood and wanted to understand logistics of chemotherapy from oncologists. Sixty-six percent of patients understood adverse effects when they were explained by nursing staff, and 56% wanted explanations of adverse effects to come from nursing staff. Patients did not prefer a specific care team member or information source when receiving financial cost information. Patients often preferred to receive chemotherapy information from their oncologist; however, other members of the care team also provided information to patients in a way that was understood.
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Male ; Patients ; Surveys and Questionnaires ; Drug-Related Side Effects and Adverse Reactions ; Patient Care Planning ; Patient Care Team
    Sprache Englisch
    Erscheinungsdatum 2023-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-022-02251-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2185: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Ocular Ischemic Syndrome and the Role of Carotid Artery Revascularization.

    Suhail, Shanzay / Tallarita, Tiziano / Kanzafarova, Irina / Lau, Jenny / Mansukhani, Sasha / Olatunji, Sunday / Calvin, Andrew D / Moustafa, Bayan / Manz, James / Sen, Indrani

    Annals of vascular surgery

    2024  Band 105, Seite(n) 165–176

    Abstract: Background: Ocular ischemic syndrome (OIS) is a rare presentation of atherosclerotic carotid artery stenosis that can result in permanent visual loss. This severely disabling syndrome remains under diagnosed and undertreated due to lack of awareness; ... ...

    Abstract Background: Ocular ischemic syndrome (OIS) is a rare presentation of atherosclerotic carotid artery stenosis that can result in permanent visual loss. This severely disabling syndrome remains under diagnosed and undertreated due to lack of awareness; especially since it requires expedited multidisciplinary care. The relevance of early diagnosis and treatment is increasing due to an increasing prevalence of cerebrovascular disease.
    Methods: The long-term visual and cerebrovascular outcomes following intervention for nonarteritic OIS, remain poorly described and were the objective of this concise review. We conducted a PubMed search to include all English language publications (cohort studies and case reports) between 2002 and 2023.
    Results: A total of 33 studies (479 patients) report the outcomes of treatment of OIS with carotid endarterectomy (CEA, 304 patients, 19 studies), and carotid artery stenting (CAS, 175 patients, 14 studies). Visual outcomes were improved or did not worsen in 447 patients (93.3%). No periprocedural stroke was reported. Worsening visual symptoms were rare (35 patients, 7.3%); they occurred in the immediate postoperative period secondary to ocular hypoperfusion (3 patients) and in the late postoperative period due to progression of systemic atherosclerotic disease. Symptomatic recurrence due to recurrent stenosis after CEA was reported in 1 patient (0.21%); this was managed successfully with CAS. None of these studies report the results of transcarotid artery revascularization, the long-term operative outcome or stroke rate.
    Conclusions: OIS remains to be an underdiagnosed condition. Early diagnosis and prompt treatment are crucial in reversal or stabilization of OIS symptoms. An expedited multidisciplinary approach between vascular surgery and ophthalmology services is necessary to facilitate timely treatment and optimize outcome. If diagnosed early, both CEA and CAS have been associated with visual improvement and prevention of progressive visual loss.
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2023.12.098
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2882: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.

    Suhail, Shanzay / Zajac, Jonathan / Fossum, Carl / Lowater, Harrison / McCracken, Cailin / Severson, Nathaniel / Laatsch, Bethany / Narkiewicz-Jodko, Alex / Johnson, Benjamin / Liebau, Jessica / Bhattacharyya, Sudeep / Hati, Sanchita

    The protein journal

    2020  Band 39, Heft 6, Seite(n) 644–656

    Abstract: Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry ... ...

    Abstract Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.
    Mesh-Begriff(e) Acetylcysteine/pharmacology ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; COVID-19/metabolism ; Drug Discovery ; Humans ; Models, Molecular ; Oxidative Stress/drug effects ; SARS Virus/physiology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Envelope Proteins/metabolism
    Chemische Substanzen Antiviral Agents ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Acetylcysteine (WYQ7N0BPYC)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2143071-8
    ISSN 1875-8355 ; 1572-3887
    ISSN (online) 1875-8355
    ISSN 1572-3887
    DOI 10.1007/s10930-020-09935-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Effects of Distal Mutations on Prolyl-Adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase.

    Zajac, Jonathan / Anderson, Heidi / Adams, Lauren / Wangmo, Dechen / Suhail, Shanzay / Almen, Aimee / Berns, Lauren / Coerber, Breanna / Dawson, Logan / Hunger, Andrea / Jehn, Julia / Johnson, Joseph / Plack, Naomi / Strasser, Steven / Williams, Murphi / Bhattacharyya, Sudeep / Hati, Sanchita

    The protein journal

    2020  Band 39, Heft 5, Seite(n) 542–553

    Abstract: Enzymes play important roles in many biological processes. Amino acid residues in the active site pocket of an enzyme, which are in direct contact with the substrate(s), are generally believed to be critical for substrate recognition and catalysis. ... ...

    Abstract Enzymes play important roles in many biological processes. Amino acid residues in the active site pocket of an enzyme, which are in direct contact with the substrate(s), are generally believed to be critical for substrate recognition and catalysis. Identifying and understanding how these "catalytic" residues help enzymes achieve enormous rate enhancement has been the focus of many structural and biochemical studies over the past several decades. Recent studies have shown that enzymes are intrinsically dynamic and dynamic coupling between distant structural elements is essential for effective catalysis in modular enzymes. Therefore, distal residues are expected to have impact on enzyme function. However, few studies have investigated the role of distal residues on enzymatic catalysis. In the present study, the effects of distal residue mutations on the catalytic function of an aminoacyl-tRNA synthetase, namely, prolyl-tRNA synthase, were investigated. The present study demonstrates that distal residues significantly contribute to catalysis of the modular Escherichia coli prolyl-tRNA synthetase by maintaining intrinsic protein flexibility.
    Mesh-Begriff(e) Amino Acyl-tRNA Synthetases/chemistry ; Amino Acyl-tRNA Synthetases/genetics ; Amino Acyl-tRNA Synthetases/metabolism ; Catalysis ; Catalytic Domain ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Mutation
    Chemische Substanzen Escherichia coli Proteins ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; prolyl T RNA synthetase (EC 6.1.1.15)
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2143071-8
    ISSN 1875-8355 ; 1572-3887
    ISSN (online) 1875-8355
    ISSN 1572-3887
    DOI 10.1007/s10930-020-09910-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review

    Suhail, Shanzay / Zajac, Jonathan / Fossum, Carl / Lowater, Harrison / McCracken, Cailin / Severson, Nathaniel / Laatsch, Bethany / Narkiewicz-Jodko, Alex / Johnson, Benjamin / Liebau, Jessica / Bhattacharyya, Sudeep / Hati, Sanchita

    Protein j

    Abstract: Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry ... ...

    Abstract Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #891911
    Datenquelle COVID19

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