LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU=Tilmann Christopher
  2. AU=Stefansson Steingrimur
  3. AU="Schindler, Tobias"
  4. AU="Araújo, Cristina de O"
  5. AU=Goda Jayant S.
  6. AU="Peditto, Piera"
  7. AU="Dünn, Hans-Wilhelm"
  8. AU=Tyznik Aaron J.
  9. AU="Siddiqui, Fasih Sami"
  10. AU="Abt, S."
  11. AU="Sultana, Sufia"
  12. AU="Yuan, Shengwang"
  13. AU="Sedehizadeh, Saam"
  14. AU=Jeon Young-Woo
  15. AU=Narayanan Navaneeth
  16. AU=Beckwith Kyle A.
  17. AU=Anderson Robert H
  18. AU=Trindade P A
  19. AU=Gohil R
  20. AU="Zhengyi, Wu"
  21. AU=Wessels J A M
  22. AU="Porter, Lavinia"
  23. AU=Al-Mayman Sulaiman

Suchergebnis

Treffer 1 - 10 von insgesamt 218

Suchoptionen

  1. Artikel ; Online: Reply to: The puzzles surrounding the impact of face masks on 6-minute walking distance in pulmonary hypertension.

    Wissmüller, Max / Wartner, Veit / Hohmann, Christopher / Adler, Joana / Kramer, Tilmann / Hellmich, Martin / Gerhardt, Felix / Baldus, Stephan / Rosenkranz, Stephan

    The European respiratory journal

    2024  Band 63, Heft 5

    Mesh-Begriff(e) Humans ; Hypertension, Pulmonary/physiopathology ; Masks ; Walking ; Walk Test ; COVID-19/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00529-2024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Systems Analysis of Highly Multiplexed CRISPR-Base Editing in Streptomycetes.

    Whitford, Christopher M / Gren, Tetiana / Palazzotto, Emilia / Lee, Sang Yup / Tong, Yaojun / Weber, Tilmann

    ACS synthetic biology

    2023  Band 12, Heft 8, Seite(n) 2353–2366

    Abstract: CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically simplified genetic manipulation of streptomycetes. One major advantage of CRISPR base editing technology is the possibility to multiplex ... ...

    Abstract CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically simplified genetic manipulation of streptomycetes. One major advantage of CRISPR base editing technology is the possibility to multiplex experiments in genomically instable species. Here, we demonstrate scaled up Csy4 based multiplexed genome editing using CRISPR-mcBEST in
    Mesh-Begriff(e) Gene Editing ; CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; RNA, Guide, CRISPR-Cas Systems ; Actinomycetales/genetics ; Systems Analysis
    Chemische Substanzen RNA, Guide, CRISPR-Cas Systems
    Sprache Englisch
    Erscheinungsdatum 2023-07-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00188
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Biosynthesis of the Azoxy Compound Azodyrecin from

    Maleckis, Matiss / Wibowo, Mario / Gren, Tetiana / Jarmusch, Scott A / Sterndorff, Eva B / Booth, Thomas / Henriksen, Nathalie N S E / Whitford, Christopher M / Jiang, Xinglin / Jørgensen, Tue S / Ding, Ling / Weber, Tilmann

    ACS chemical biology

    2024  Band 19, Heft 3, Seite(n) 641–653

    Abstract: Azoxy compounds are a distinctive group of bioactive secondary metabolites characterized by a unique RN═ ... ...

    Abstract Azoxy compounds are a distinctive group of bioactive secondary metabolites characterized by a unique RN═N
    Mesh-Begriff(e) Phylogeny ; Tandem Mass Spectrometry ; Streptomyces/genetics ; Streptomyces/metabolism ; Multigene Family
    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00632
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Impact of face masks on the 6-minute walk distance in pulmonary hypertension patients during the COVID-19 pandemic: a prospective, randomised cross-over study.

    Wissmüller, Max / Wartner, Veit / Hohmann, Christopher / Adler, Joana / Kramer, Tilmann / Hellmich, Martin / Gerhardt, Felix / Baldus, Stephan / Rosenkranz, Stephan

    The European respiratory journal

    2023  Band 62, Heft 4

    Mesh-Begriff(e) Humans ; COVID-19 ; Hypertension, Pulmonary ; Pandemics ; Prospective Studies ; Masks ; Cross-Over Studies
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland England
    Dokumenttyp Randomized Controlled Trial ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01454-2022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing

    Yaojun Tong / Tue S. Jørgensen / Christopher M. Whitford / Tilmann Weber / Sang Yup Lee

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 11

    Abstract: CRISPR prime editing enables double-strand break free engineering of the genome. Here the authors present a toolkit for prime editing in E. coli. ...

    Abstract CRISPR prime editing enables double-strand break free engineering of the genome. Here the authors present a toolkit for prime editing in E. coli.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: The Design-Build-Test-Learn cycle for metabolic engineering of Streptomycetes.

    Whitford, Christopher M / Cruz-Morales, Pablo / Keasling, Jay D / Weber, Tilmann

    Essays in biochemistry

    2021  Band 65, Heft 2, Seite(n) 261–275

    Abstract: Streptomycetes are producers of a wide range of specialized metabolites of great medicinal and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the drivers of the golden age of antibiotics in the 1950s and 1960s, ... ...

    Abstract Streptomycetes are producers of a wide range of specialized metabolites of great medicinal and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the drivers of the golden age of antibiotics in the 1950s and 1960s, technological advancements over the last two decades have revealed that very little of their biosynthetic potential has been exploited so far. Given the great need for new antibiotics due to the emerging antimicrobial resistance crisis, as well as the urgent need for sustainable biobased production of complex molecules, there is a great renewed interest in exploring and engineering the biosynthetic potential of streptomycetes. Here, we describe the Design-Build-Test-Learn (DBTL) cycle for metabolic engineering experiments in streptomycetes and how it can be used for the discovery and production of novel specialized metabolites.
    Mesh-Begriff(e) Anti-Bacterial Agents ; Metabolic Engineering
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2021-05-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1744-1358 ; 0071-1365
    ISSN (online) 1744-1358
    ISSN 0071-1365
    DOI 10.1042/EBC20200132
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: High-Quality Sequencing, Assembly, and Annotation of the Streptomyces griseofuscus DSM 40191 Genome.

    Gren, Tetiana / Jørgensen, Tue S / Whitford, Christopher M / Weber, Tilmann

    Microbiology resource announcements

    2020  Band 9, Heft 47

    Abstract: Here, we report the sequencing, assembly, and annotation of the genome ... ...

    Abstract Here, we report the sequencing, assembly, and annotation of the genome of
    Sprache Englisch
    Erscheinungsdatum 2020-11-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01100-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Buch ; Online: Quantification of electronic and magnetoelastic mechanisms of first-order magnetic phase transitions from first principles

    Tapia, Eduardo Mendive / Patrick, Christopher E. / Hickel, Tilmann / Neugebauer, Jörg / Staunton, Julie B.

    application to caloric effects in La(Fe$_x$Si$_{1-x}$)$_{13}$

    2023  

    Abstract: La(Fe$_x$Si$_{1-x}$)$_{13}$ and derived quaternary compounds are well-known for their giant, tunable, magneto- and barocaloric responses around a first-order paramagnetic-ferromagnetic transition near room temperature with low hysteresis. Remarkably, ... ...

    Abstract La(Fe$_x$Si$_{1-x}$)$_{13}$ and derived quaternary compounds are well-known for their giant, tunable, magneto- and barocaloric responses around a first-order paramagnetic-ferromagnetic transition near room temperature with low hysteresis. Remarkably, such a transition shows a large spontaneous volume change together with itinerant electron metamagnetic features. While magnetovolume effects are well-established mechanisms driving first-order transitions, purely electronic sources have a long, subtle history and remain poorly understood. Here we apply a disordered local moment picture to quantify electronic and magnetoelastic effects at finite temperature in La(Fe$_x$Si$_{1-x}$)$_{13}$ from first-principles. We obtain results in very good agreement with experiment and demonstrate that the magnetoelastic coupling, rather than purely electronic mechanisms, drives the first-order character and causes at the same time a huge electronic entropy contribution to the caloric response.

    Comment: 20 pages, 6 figures
    Schlagwörter Condensed Matter - Materials Science
    Thema/Rubrik (Code) 530
    Erscheinungsdatum 2023-02-13
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  9. Buch ; Online ; Dissertation / Habilitation: Zur Interaktion des Epidermal Growth Factor mit Corticosteroiden bei der Regulation des L-Typ Ca2+ Stromes in isolierten linksventrikulären Kardiomyozyten der Ratte

    Frohberg, Andreas [Verfasser] / Volk, Tilmann [Akademischer Betreuer] / Volk, Tilmann [Gutachter] / Korbmacher, Christopher [Gutachter]

    2021  

    Verfasserangabe Andreas Frohberg ; Gutachter: Tilmann Volk, Christopher Korbmacher ; Betreuer: Tilmann Volk
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Erscheinungsort Erlangen
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Impact of rapid sequential combination therapy on distinct haemodynamic measures in newly diagnosed pulmonary arterial hypertension.

    Kramer, Tilmann / Nattmann, Phillip / Gerhardt, Felix / Stafiej, Patrycja / Dumitrescu, Daniel / Ten Freyhaus, Henrik / Wißmüller, Max / Hohmann, Christopher / Baldus, Stephan / Rosenkranz, Stephan

    ESC heart failure

    2024  Band 11, Heft 3, Seite(n) 1540–1552

    Abstract: Aims: In pulmonary arterial hypertension (PAH), upfront combination therapy with ERA and PDE5i is associated with a reduction in morbidity and mortality events and improves standard haemodynamics, but data remain limited. Aims of this study were (i) to ... ...

    Abstract Aims: In pulmonary arterial hypertension (PAH), upfront combination therapy with ERA and PDE5i is associated with a reduction in morbidity and mortality events and improves standard haemodynamics, but data remain limited. Aims of this study were (i) to capture detailed haemodynamic effects of rapid sequential dual combination therapy in patients with newly diagnosed PAH; (ii) to monitor the impact of treatment initiation on clinical variables and patients' risk status, and (iii) to compare the treatment effect in patients with 'classical PAH' and 'PAH with co-morbidities'.
    Methods: Fifty patients (median age 57 [42-71] years, 66% female) with newly diagnosed PAH (76% idiopathic) were treated with a PD5i/sGC-S or ERA, followed by addition of the respective other drug class within 4 weeks. All patients underwent repeat right heart catheterization (RHC) during early follow-up.
    Results: At early repeat RHC (7 ± 2 months), there were substantial reductions in mean pulmonary artery pressure (mPAP: 52.2 ± 13.5 to 39.0 ± 10.6 mmHg; -25.3%), and pulmonary vascular resistance (PVR: 12.1 ± 5.7 to 5.8 ± 3.1 WU; -52.1%), and an increase in cardiac index (2.1 ± 0.4 to 2.7 ± 0.7 mL/min/m
    Conclusions: Rapid sequential combination therapy with PDE5i/sGC-S and ERA substantially ameliorates cardiopulmonary haemodynamics at early follow-up in patients without, and to a lesser extent, with cardiovascular co-morbidities. This occurs in line with improvements of clinical parameters and risk status.
    Mesh-Begriff(e) Humans ; Female ; Male ; Middle Aged ; Hemodynamics/physiology ; Hemodynamics/drug effects ; Aged ; Drug Therapy, Combination ; Adult ; Phosphodiesterase 5 Inhibitors/administration & dosage ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/diagnosis ; Follow-Up Studies ; Treatment Outcome ; Cardiac Catheterization/methods ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Vascular Resistance ; Time Factors ; Endothelin Receptor Antagonists/administration & dosage
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14611
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang