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  1. AU=Turilli Emily Samuela
  2. AU="Rueckert, Erroll H"
  3. AU=Keestra-Gounder A. Marijke
  4. AU="María José Endara"
  5. AU="Li, Lin-Zi"
  6. AU="Shirvanian, Moein"
  7. AU="Capaldo, Bianca D"
  8. AU="Matose, Takunda"
  9. AU=Plouffe Brian D.
  10. AU=Kuter David J
  11. AU="Moore, I D"
  12. AU="Schreibing, Felix"
  13. AU=Kang Keunsoo
  14. AU="de Pedro-Múñez, Álvaro"

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  1. Artikel ; Online: Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins.

    Turilli-Ghisolfi, Emily Samuela / Lualdi, Marta / Fasano, Mauro

    Biomolecules

    2023  Band 13, Heft 4

    Abstract: Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of ... ...

    Abstract Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of hemoproteins in terms of dynamics and reactivity. First, we describe how ligands modulate cooperativity and reactivity in globins, such as myoglobin and hemoglobin. Second, we move on to another family of hemoproteins devoted to electron transport, such as cytochromes. Later, we consider heme-based reactivity in hemopexin, the main heme-scavenging protein. Then, we focus on heme-albumin, a chronosteric hemoprotein with peculiar spectroscopic and enzymatic properties. Eventually, we analyze the reactivity and dynamics of the most recently discovered family of hemoproteins, i.e., nitrobindins.
    Mesh-Begriff(e) Heme/metabolism ; Ligands ; Hemeproteins/chemistry ; Hemeproteins/metabolism
    Chemische Substanzen Heme (42VZT0U6YR) ; Ligands ; Hemeproteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13040683
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Looking at COVID-19 from a Systems Biology Perspective.

    Turilli, Emily Samuela / Lualdi, Marta / Fasano, Mauro

    Biomolecules

    2022  Band 12, Heft 2

    Abstract: The sudden outbreak and worldwide spread of the SARS-CoV-2 pandemic pushed the scientific community to find fast solutions to cope with the health emergency. COVID-19 complexity, in terms of clinical outcomes, severity, and response to therapy suggested ... ...

    Abstract The sudden outbreak and worldwide spread of the SARS-CoV-2 pandemic pushed the scientific community to find fast solutions to cope with the health emergency. COVID-19 complexity, in terms of clinical outcomes, severity, and response to therapy suggested the use of multifactorial strategies, characteristic of the network medicine, to approach the study of the pathobiology. Proteomics and interactomics especially allow to generate datasets that, reduced and represented in the forms of networks, can be analyzed with the tools of systems biology to unveil specific pathways central to virus-human host interaction. Moreover, artificial intelligence tools can be implemented for the identification of druggable targets and drug repurposing. In this review article, we provide an overview of the results obtained so far, from a systems biology perspective, in the understanding of COVID-19 pathobiology and virus-host interactions, and in the development of disease classifiers and tools for drug repurposing.
    Mesh-Begriff(e) Animals ; Artificial Intelligence ; COVID-19 ; Drug Repositioning ; Host Microbial Interactions ; Humans ; Systems Biology
    Sprache Englisch
    Erscheinungsdatum 2022-01-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12020188
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Mycobacterial and Human Nitrobindins: Structure and Function.

    De Simone, Giovanna / di Masi, Alessandra / Vita, Gian Marco / Polticelli, Fabio / Pesce, Alessandra / Nardini, Marco / Bolognesi, Martino / Ciaccio, Chiara / Coletta, Massimo / Turilli, Emily Samuela / Fasano, Mauro / Tognaccini, Lorenzo / Smulevich, Giulietta / Abbruzzetti, Stefania / Viappiani, Cristiano / Bruno, Stefano / Ascenzi, Paolo

    Antioxidants & redox signaling

    2020  Band 33, Heft 4, Seite(n) 229–246

    Abstract: Aims: ...

    Abstract Aims:
    Mesh-Begriff(e) Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Heme/chemistry ; Heme/metabolism ; Humans ; Models, Molecular ; Mycobacterium ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Recombinant Proteins ; Salivary Proteins and Peptides/chemistry ; Salivary Proteins and Peptides/metabolism ; Structure-Activity Relationship
    Chemische Substanzen Bacterial Proteins ; Recombinant Proteins ; Salivary Proteins and Peptides ; nitrophorin ; Heme (42VZT0U6YR)
    Sprache Englisch
    Erscheinungsdatum 2020-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2019.7874
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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