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  1. Article ; Online: Auricular myoclonus associated with intra-abdominal botryomycosis in a dog.

    Ceplecha, V / Shea, A / Frances, M / Proks, P / Williams, J / Irving, J / Rehakova, K / Vlasin, M / Mala, B / Miller, A

    The Journal of small animal practice

    2023  Volume 64, Issue 12, Page(s) 806

    MeSH term(s) Dogs ; Animals ; Myoclonus/diagnosis ; Myoclonus/veterinary ; Granuloma/veterinary ; Dog Diseases/diagnosis
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.13658
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 590: Show issues Location:
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  2. Article ; Online: Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK.

    Gualdi, Francesco / Smith, Isabelle Granville / Boixader, Roger Compte / Williams, Frances M K

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 10, Page(s) 3379–3386

    Abstract: Purpose: Low back pain (LBP) is one of the largest causes of morbidity worldwide. The aetiology of LBP is complex, and many factors contribute to the onset. Bone marrow lesions within the vertebra adjacent to an intervertebral degenerate disc named ... ...

    Abstract Purpose: Low back pain (LBP) is one of the largest causes of morbidity worldwide. The aetiology of LBP is complex, and many factors contribute to the onset. Bone marrow lesions within the vertebra adjacent to an intervertebral degenerate disc named Modic change (MC) have been suggested as a diagnostic subgroup of LBP. Autoimmune response has been proposed to be one of the causes that promote the development of MC. The aim of the current investigation is to assess prevalence and severity of MC and LBP in participants with an autoimmune disease diagnosis in a well-documented cohort of adult twin volunteers.
    Methods: Multivariate generalized mixed linear models (GLMM) were implemented in order to calculate the association between having an autoimmune disorder and MC prevalence, width and severe and disabling LBP. The model was corrected for family structure as well as for covariates such as age, BMI and smoking.
    Results: No association was found between diagnosis of autoimmune disorder and MC. Interestingly, BMI was independently associated with MC width but not to MC prevalence. These results help to shed light on the relationship between MC and autoimmunity as well as the role of BMI in the development of the lesions.
    Conclusion: This study is the first to examine autoimmune disorders and MC prevalence in a large, population-based female cohort. The study was well powered to detect a small effect. No association was found between having a diagnosis of one or more autoimmune conditions and MC prevalence, width or LBP.
    MeSH term(s) Adult ; Humans ; Female ; Intervertebral Disc Degeneration/pathology ; Lumbar Vertebrae/pathology ; Body Mass Index ; Magnetic Resonance Imaging/methods ; Low Back Pain/epidemiology ; Low Back Pain/etiology ; Low Back Pain/pathology ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/complications ; Autoimmune Diseases/pathology
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07870-7
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    Zs.A 3437: Show issues Location:
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  3. Article ; Online: Covid-19 and chronic fatigue.

    Williams, Frances M K / Muirhead, Nina / Pariante, Carmine

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2922

    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetic and environmental correlational structure among metabolic syndrome endophenotypes.

    Cherny, Stacey S / Williams, Frances M K / Livshits, Gregory

    Annals of human genetics

    2022  Volume 86, Issue 5, Page(s) 225–236

    Abstract: Metabolic syndrome (MetS) is diagnosed by the presence of high scores on three or more metabolic traits, including systolic and diastolic blood pressure (SBP, DBP), glucose and insulin levels, cholesterol and triglyceride (TG) levels, and central obesity. ...

    Abstract Metabolic syndrome (MetS) is diagnosed by the presence of high scores on three or more metabolic traits, including systolic and diastolic blood pressure (SBP, DBP), glucose and insulin levels, cholesterol and triglyceride (TG) levels, and central obesity. A diagnosis of MetS is associated with increased risk of cardiovascular disease and type 2 diabetes. The components of MetS have long been demonstrated to have substantial genetic components, but their genetic overlap is less well understood. The present paper takes a multi-prong approach to examining the extent of this genetic overlap. This includes the quantitative genetic and additive Bayesian network modeling of the large TwinsUK project and examination of the results of genome-wide association study (GWAS) of UK Biobank data through use of LD score regression and examination of the number of genes and pathways identified in the GWASes which overlap across MetS traits. Results demonstrate a modest genetic overlap, and the genetic correlations obtained from TwinsUK and UK Biobank are nearly identical. However, these correlations imply more genetic dissimilarity than similarity. Furthermore, examination of the extent of overlap in significant GWAS hits, both at the gene and pathway level, again demonstrates only modest but significant genetic overlap. This lends support to the idea that in clinical treatment of MetS, treating each of the components individually may be an important way to address MetS.
    MeSH term(s) Bayes Theorem ; Blood Glucose ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Endophenotypes ; Genome-Wide Association Study ; Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/genetics ; Risk Factors ; Triglycerides
    Chemical Substances Blood Glucose ; Triglycerides
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 333-5
    ISSN 1469-1809 ; 0003-4800
    ISSN (online) 1469-1809
    ISSN 0003-4800
    DOI 10.1111/ahg.12465
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  5. Article ; Online: No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins.

    Compte, Roger / Freidin, Maxim B / Granville Smith, Isabelle / Le Maitre, Christine L / Vaitkute, Dovile / Nessa, Ayrun / Lachance, Genevieve / Williams, Frances M K

    JOR spine

    2024  Volume 7, Issue 1, Page(s) e1323

    Abstract: Introduction: Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to ... ...

    Abstract Introduction: Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.
    Materials and methods: Two hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL-6, IL-8, IL-8 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested.
    Results: No statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL-6 and with age for IL-6 and TNF. Mild association was found between IL-8 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration.
    Conclusions: We found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1323
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  6. Article ; Online: Chemical Recycling of Poly(Cyclohexene Carbonate) Using a Di-Mg

    Singer, Frances N / Deacy, Arron C / McGuire, Thomas M / Williams, Charlotte K / Buchard, Antoine

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 26, Page(s) e202201785

    Abstract: Chemical recycling of polymers to true monomers is pivotal for a circular plastics economy. Here, the first catalyzed chemical recycling of the widely investigated carbon dioxide derived polymer, poly(cyclohexene carbonate), to cyclohexene oxide and ... ...

    Abstract Chemical recycling of polymers to true monomers is pivotal for a circular plastics economy. Here, the first catalyzed chemical recycling of the widely investigated carbon dioxide derived polymer, poly(cyclohexene carbonate), to cyclohexene oxide and carbon dioxide is reported. The reaction requires dinuclear catalysis, with the di-Mg
    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202201785
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  8. Book ; Online: Covid-19 and chronic fatigue

    Williams, Frances M K / Muirhead, Nina / Pariante, Carmine

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-07-30 09:46:26.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Covid-19 and chronic fatigue

    Williams, Frances M K / Muirhead, Nina / Pariante, Carmine

    BMJ

    2020  , Page(s) m2922

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2922
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Ua VI Zs.10: Show issues Location:
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  10. Article ; Online: Genotype-by-environment interactions in chronic back pain.

    Kuznetsov, Ivan A / Tsepilov, Yakov A / Freidin, Maxim B / Williams, Frances M K / Suri, Pradeep / Aulchenko, Yurii S

    The spine journal : official journal of the North American Spine Society

    2023  Volume 23, Issue 8, Page(s) 1108–1114

    Abstract: Background context: Chronic back pain (CBP) is a common debilitating condition with substantial societal impact. While understanding genotype-by-environment (GxE) interactions may be crucial to achieving the goals of personalized medicine, there are few ...

    Abstract Background context: Chronic back pain (CBP) is a common debilitating condition with substantial societal impact. While understanding genotype-by-environment (GxE) interactions may be crucial to achieving the goals of personalized medicine, there are few large-scale studies investigating this topic for CBP. None of them systematically explore multiple CBP risk factors.
    Purpose: To estimate the extent to which genetic effects on CBP are modified by known demographic and clinical risk factors.
    Research design: Case-control study, genome-wide GxE interaction study.
    Patient sample: Data on up to 331,610 unrelated participants (57,881 CBP cases and 273,729 controls) from the UK Biobank cohort were used. UK Biobank is a prospective cohort with collected deep genetic and phenotypic data on approximately 500,000 individuals across the UK.
    Outcome measures: Self-reported chronic back pain.
    Methods: We applied a whole-genome approach to estimate the proportion of phenotypic variance explained by interactions between genotype and 12 known risk factors. We also analyzed if effects of common single-nucleotide polymorphisms on CBP are changed in presence of known risk factors.
    Results: The results indicate a modest, if any, modification of genetic effects by examined risk factors in CBP. Our estimates suggest that detecting such weak effects would require a sample size of millions of individuals.
    Conclusions: The GxE interactions with examined common risk factors for CBP are either weak or absent. Interactions of such magnitude are unlikely to have the potential to inform and influence treatment strategies. Risk estimation models may use common genetic variation and the considered risk factors as independent predictors, without accounting for GxE.
    MeSH term(s) Humans ; Gene-Environment Interaction ; Case-Control Studies ; Prospective Studies ; Back Pain/epidemiology ; Back Pain/genetics ; Genotype
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2023.04.009
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