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  1. Article: [Prevalence and change of type 2 diabetes mellitus among rural adults in Deqing County, Zhejiang Province in China during 2006-2014].

    Chen, Xiaoying / Wu, Zhaofan / Wang, Xuecai / Chen, Yue / Dong, Xiaolian / Zhu, Jianfu / Xiao, Tian / Jiang, Qingwu / Fu, Chaowei

    Wei sheng yan jiu = Journal of hygiene research

    2018  Volume 46, Issue 6, Page(s) 868–887

    Abstract: Objective: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County ... rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011 ... with T2 DM.: Conclusion: The prevalence of T2 DM increased over time in rural Deqing County, China. Age ...

    Abstract Objective: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County, Zhejiang Province, and explore its risk factors.
    Methods: Random cluster sampling was used to select 8 rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011-2012 and 2013-2014, respectively. Totally, 6562 eligible subjects were investigated in 2006-2008, 11 763 eligible subjects in 2011-2012, and 10 904 eligible subjects in 2013-2014. Data on demography, life style and disease history, and physical examination such as height, weight and blood pressure were collected. Also, fasting plasma glucose was tested. T2 DM was defined as who having fasting plasma glucose ≥7. 0 mmol/L or was diagnosed by doctors or receiving diabetic treatment.
    Results: In 2006-2008, 2011-2012 and 2013-2014, the standardized prevalences of T2 DM were 1. 2%, 1. 6% and 2. 1% and those of impaired fasting glucose( IFG) were 7. 2%, 18. 7% and22. 8%, respectively. There were increasing trends over years for both. After adjustment for other covariates in logistic regression, age( compared with age between 18 to 39. 9 years old: aOR_(40-59. 9)= 5. 20, 95% CI 2. 74-9. 89; aOR_(60-)= 8. 02, 95% CI 4. 19-15. 35), female( aOR = 1. 23, 95% CI 1. 02-1. 49), family history of T2 DM( aOR =4. 86, 95% CI 3. 49-6. 77), overweight/obesity( overweight: aOR = 1. 88, 95% CI1. 61-2. 20; obesity: aOR = 5. 10, 95% CI 4. 06-6. 41), hypertension( aOR = 2. 84, 95% CI 2. 44-3. 31), having meat mainly( aOR = 2. 25, 95% CI 1. 89-2. 69) and tea drinking( aOR = 0. 81, 95% CI 0. 68-0. 95) were significantly correlated with T2 DM.
    Conclusion: The prevalence of T2 DM increased over time in rural Deqing County, China. Age, gender, family history of T2 DM, overweight or obesity, hypertension, diet and drinking tea were significantly related to T2 DM.
    MeSH term(s) Adolescent ; Adult ; Blood Glucose/analysis ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Prediabetic State ; Prevalence ; Risk Factors ; Rural Population ; Young Adult
    Chemical Substances Blood Glucose
    Language Chinese
    Publishing date 2018-06-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 1050909-4
    ISSN 1000-8020
    ISSN 1000-8020
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  2. Article ; Online: Evaluation of the Effects of Meal Type and Acid-Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

    Weber, Elijah J / Younis, Islam R / Wang, Lulu / Xiao, Deqing / Barchuk, William T / Othman, Ahmed A

    Clinical pharmacology in drug development

    2024  

    Abstract: Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid-reducing agents (ARAs) on ... ...

    Abstract Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid-reducing agents (ARAs) on the pharmacokinetics of cilofexor (100- or 30-mg fixed-dose combination with firsocostat) in healthy participants. Cohorts 1 (n = 20, 100 mg) and 2 (n = 30, 30 mg) followed a 3-period, 2-sequence crossover design and evaluated effects of light-fat and high-fat meals. Cohort 3 (n = 30, 100 mg fasting) followed a 2-period, 2-sequence crossover design and evaluated the effects of a 40-mg single dose of famotidine. Cohort 4 (n = 18, 100 mg) followed a 3-period, 2-sequence crossover design and evaluated the effects of a 40-mg once-daily regimen of omeprazole administered under fasting conditions or following a light-fat meal. Administration with light-fat or high-fat meals resulted in no change and an ∼35% reduction in cilofexor AUC, respectively, relative to the fasting conditions. Under fasting conditions, famotidine increased cilofexor AUC by 3.2-fold and C
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649010-9
    ISSN 2160-7648 ; 2160-763X
    ISSN (online) 2160-7648
    ISSN 2160-763X
    DOI 10.1002/cpdd.1384
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  3. Article ; Online: UV-stimulated riboflavin exerts immunosuppressive effects in BALB/c mice and human PBMCs.

    Chen, Xinghui / Ge, Shuang / Xiao, Pan / Liu, Yulin / Yu, Yang / Liu, Yi / Sun, Liping / Yang, Lu / Wang, Deqing

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116278

    Abstract: Riboflavin (RF) as a photosensitizer has been used in corneal surgery and the inactivation of blood products. However, the effect of RF on immune cells after ultraviolet (UV) light stimulation has not been investigated. This study pioneered a novel ... ...

    Abstract Riboflavin (RF) as a photosensitizer has been used in corneal surgery and the inactivation of blood products. However, the effect of RF on immune cells after ultraviolet (UV) light stimulation has not been investigated. This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed. UV-stimulated RF was then administered intravenously to mice via the tail vein for a consecutive period of 5 days. The levels of immunoglobulin (IgG, IgM, IgA), complement (C3, C4) and cytokines (IFN-γ, IL-4, IL17, TGF-β) were detected by ELISA. Flow cytometry was employed to analyze the populations of CD3+T, CD4+T, CD8+T and CD4+T/CD8+T cells in spleen lymphocytes of mice. The data showed that UV-stimulated RF can effectively induce apoptosis in lymphocytes, and different lymphocyte subtypes exhibited varying degrees of treatment tolerance. Additionally, the proliferative capacity of lymphocytes was suppressed, while their cytokine secretion capability was augmented. The animal experiments demonstrated that UV-stimulated RF led to a significant reduction observed in serum immunoglobulin and complement levels, accompanied by an elevation in IFN-γ, IL-17 and TGF-β levels, as well as a decline in IL-4 level. In summary, the results of both in vitro and in vivo experiments have demonstrated that UV-stimulated RF, exhibits the ability to partially inhibit immune function. This novel approach utilizing RF may offer innovative perspectives for diseases requiring immunosuppressive treatment.
    MeSH term(s) Humans ; Mice ; Animals ; Leukocytes, Mononuclear ; Interleukin-4/pharmacology ; Mice, Inbred BALB C ; Cytokines/pharmacology ; Riboflavin/pharmacology ; Transforming Growth Factor beta/pharmacology ; Immunoglobulins/pharmacology ; CD4-Positive T-Lymphocytes
    Chemical Substances Interleukin-4 (207137-56-2) ; Cytokines ; Riboflavin (TLM2976OFR) ; Transforming Growth Factor beta ; Immunoglobulins
    Language English
    Publishing date 2024-02-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116278
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    Ud II Zs.198: Show issues Location:
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  4. Book ; Online: Beneath Surface Similarity

    Yuan, Siyu / Chen, Jiangjie / Ge, Xuyang / Xiao, Yanghua / Yang, Deqing

    Large Language Models Make Reasonable Scientific Analogies after Structure Abduction

    2023  

    Abstract: The vital role of analogical reasoning in human cognition allows us to grasp novel concepts by linking them with familiar ones through shared relational structures. Despite the attention previous research has given to word analogies, this work suggests ... ...

    Abstract The vital role of analogical reasoning in human cognition allows us to grasp novel concepts by linking them with familiar ones through shared relational structures. Despite the attention previous research has given to word analogies, this work suggests that Large Language Models (LLMs) often overlook the structures that underpin these analogies, raising questions about the efficacy of word analogies as a measure of analogical reasoning skills akin to human cognition. In response to this, our paper introduces a task of analogical structure abduction, grounded in cognitive psychology, designed to abduce structures that form an analogy between two systems. In support of this task, we establish a benchmark called SCAR, containing 400 scientific analogies from 13 distinct fields, tailored for evaluating analogical reasoning with structure abduction. The empirical evidence underlines the continued challenges faced by LLMs, including ChatGPT and GPT-4, in mastering this task, signifying the need for future exploration to enhance their abilities.

    Comment: Accepted to EMNLP 2023 (Findings)
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
    Subject code 401
    Publishing date 2023-05-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Factorial User Modeling with Hierarchical Graph Neural Network for Enhanced Sequential Recommendation

    Xue, Lyuxin / Yang, Deqing / Xiao, Yanghua

    2022  

    Abstract: Most sequential recommendation (SR) systems employing graph neural networks (GNNs) only model a user's interaction sequence as a flat graph without hierarchy, overlooking diverse factors in the user's preference. Moreover, the timespan between interacted ...

    Abstract Most sequential recommendation (SR) systems employing graph neural networks (GNNs) only model a user's interaction sequence as a flat graph without hierarchy, overlooking diverse factors in the user's preference. Moreover, the timespan between interacted items is not sufficiently utilized by previous models, restricting SR performance gains. To address these problems, we propose a novel SR system employing a hierarchical graph neural network (HGNN) to model factorial user preferences. Specifically, a timespan-aware sequence graph (TSG) for the target user is first constructed with the timespan among interacted items. Next, all original nodes in TSG are softly clustered into factor nodes, each of which represents a certain factor of the user's preference. At last, all factor nodes' representations are used together to predict SR results. Our extensive experiments upon two datasets justify that our HGNN-based factorial user modeling obtains better SR performance than the state-of-the-art SR models.

    Comment: Accepted by ICME 2022
    Keywords Computer Science - Information Retrieval
    Publishing date 2022-07-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Effects of low-concentration spinetoram wax-based bait stations on Bactrocera dorsalis (Diptera: Tephritidae).

    Lin, Jia / Yue, Guoqing / Xiao, Kang / Yang, Deqing / Hao, Xuxing / Zheng, Minlin / Cai, Pumo / Ji, Qing'e

    Pesticide biochemistry and physiology

    2023  Volume 197, Page(s) 105705

    Abstract: Spinetoram wax-based bait station (SWBB) is a maintenance-free, long-lasting, and eco-friendly management measure for Bactrocera dorsalis. However, the impacts of low-concentration spinetoram on B. dorsalis have not yet been determined. Therefore, our ... ...

    Abstract Spinetoram wax-based bait station (SWBB) is a maintenance-free, long-lasting, and eco-friendly management measure for Bactrocera dorsalis. However, the impacts of low-concentration spinetoram on B. dorsalis have not yet been determined. Therefore, our study aimed to determine the impacts of low-concentration SWBBs on the biology, demographics, detoxifying enzymes, and gut microorganisms of B. dorsalis. Our results showed that low-concentration SWBBs posed dose-dependent effects on the lifespan and fecundity of B. dorsalis adults. Both the LC
    MeSH term(s) Animals ; Tephritidae ; Macrolides/pharmacology ; Fertility
    Chemical Substances spinetoram (YGZ1037ELN) ; Macrolides
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184819-7
    ISSN 1095-9939 ; 0048-3583 ; 0048-3575
    ISSN (online) 1095-9939
    ISSN 0048-3583 ; 0048-3575
    DOI 10.1016/j.pestbp.2023.105705
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    In stock of ZB MED Bonn / Germany

    Z 3585: Show issues

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  7. Article ; Online: The complete mitochondrial genome of

    Yang, Deqing / Hao, Xuxing / Jiang, Lili / Chou, Tsunglin / Lin, Xiang / Yue, Guoqing / Xiao, Kang / Lin, Jia / Ji, Qinge / Cai, Pumo

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 6, Page(s) 1038–1040

    Abstract: Psyttalia ... ...

    Abstract Psyttalia incisi
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2081942
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  8. Article ; Online: The interaction of environmental factors increases the risk of spatiotemporal transmission of pine wilt disease

    Xiao Lu / Jixia Huang / Xiaodong Li / Guofei Fang / Deqing Liu

    Ecological Indicators, Vol 133, Iss , Pp 108394- (2021)

    2021  

    Abstract: The Yangtze River basin contains one-third of the important ecological function areas in China. In recent years, pine wilt disease (PWD) has broken out in many provinces in this region, causing serious damage to the forest ecological environment. There ... ...

    Abstract The Yangtze River basin contains one-third of the important ecological function areas in China. In recent years, pine wilt disease (PWD) has broken out in many provinces in this region, causing serious damage to the forest ecological environment. There have been many studies on the risk attribution of PWD at the stand scale but few macroscale studies. In this study, 1104 county-level administrative regions in the Yangtze River basin constituted the study area. We surveyed the epidemic of PWD and environmental factor data for the region. Taking into account the spatial heterogeneity of the risk of PWD occurrence, we conducted a macroscale attribution study on the risk of PWD outbreaks using GeoDetector. In 2000, 2005, 2010 and 2015, there were 51, 100, 101 and 126 affected counties in the Yangtze River basin, and the global Moran's I index of the incidence of PWD was 0.445, 0.220, 0.151 and 0.143, respectively. The spatial autocorrelation of the incidence of PWD has been decreasing annually, showing a trend with multi-point bursts. The number of affected counties has continued to increase in the central and western parts of the Yangtze River basin, and the mean centre of the affected areas has continued to move to the southwest. The risk detector shows that areas with high wind speed and many sunshine hours are the potential high-risk areas for PWD. The factor detector shows that the normalized difference vegetation index (NDVI), average wind speed and sunshine hours have the strongest effect on the incidence of PWD, with explanatory power of 20.5%, 20.3% and 10.4%, respectively. The interaction between average wind speed and NDVI and the interaction between average relative humidity and sunshine hours show a significant nonlinear enhancement effect, with their explanatory power reaching 64.7% and 60.8%, respectively. Analysis of the spatiotemporal data on PWD in the Yangtze River basin revealed a westward transmission pattern of PWD in the study area, and the interaction of environmental factors could increase ...
    Keywords Yangtze River basin ; Pine wilt disease ; Spatial autocorrelation ; Spatiotemporal transmission ; Geodetector ; Ecology ; QH540-549.5
    Subject code 910
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Group Buying Recommendation Model Based on Multi-task Learning

    Zhai, Shuoyao / Liu, Baichuan / Yang, Deqing / Xiao, Yanghua

    2022  

    Abstract: In recent years, group buying has become one popular kind of online shopping activity, thanks to its larger sales and lower unit price. Unfortunately, research seldom focuses on recommendations specifically for group buying by now. Although some ... ...

    Abstract In recent years, group buying has become one popular kind of online shopping activity, thanks to its larger sales and lower unit price. Unfortunately, research seldom focuses on recommendations specifically for group buying by now. Although some recommendation models have been proposed for group recommendation, they can not be directly used to achieve real-world group buying recommendation, due to the essential difference between group recommendation and group buying recommendation. In this paper, we first formalize the task of group buying recommendations into two sub-tasks. Then, based on our insights into the correlations and interactions between the two sub-tasks, we propose a novel recommendation model for group buying, MGBR, built mainly with a multi-task learning module. To improve recommendation performance further, we devise some collaborative expert networks and adjusted gates in the multi-task learning module, to promote the information interaction between the two sub-tasks. Furthermore, we propose two auxiliary losses corresponding to the two sub-tasks, to refine the representation learning in our model. Our extensive experiments not only demonstrate that the augmented representations in our model result in better performance than previous recommendation models, but also justify the impacts of the specially designed components in our model.
    Keywords Computer Science - Information Retrieval
    Subject code 006
    Publishing date 2022-11-25
    Publishing country us
    Document type Book ; Online
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  10. Article: Identification of Marek's disease virus pUL56 homologue and analysis of critical amino acid stretches indispensable for its intracellular localization

    Zhang, Jincheng / Xu, Beibei / Ma, Deqing / Song, Jialing / Liu, Xiao / Wei, Ping / Huang, Teng

    Virus research. 2022 May, v. 313

    2022  

    Abstract: Marek's disease virus (MDV) is considered a unique member of the Alphaherpesvirinae subfamily that induces rapid onset of T cell lymphoma in chickens. Compared with other conserved UL56 gene homologues of herpesviruses, little is known about the roles of ...

    Abstract Marek's disease virus (MDV) is considered a unique member of the Alphaherpesvirinae subfamily that induces rapid onset of T cell lymphoma in chickens. Compared with other conserved UL56 gene homologues of herpesviruses, little is known about the roles of MDV UL56 gene, while recent studies of mammalian herpesvirus pUL56 proteins have revealed their involvement in promoting ubiquitination of the Nedd4 (neural precursor cell expressed developmentally down-regulated protein 4) -like E3 ubiquitin ligases for proteasomal degradation and in modulating host immune responses. To determine the expression kinetics of UL56 gene products, chicken embryo fibroblasts were infected with very virulent or attenuated MDV strain and analyzed by quantitative PCR and Western blotting. During the time course of infection, the levels of UL56 mRNA transcripts increased consistently. At the translational level, the pUL56 protein encoded by UL56 gene was expressed in the size of 32 kDa, which emerged as early as 12 h post-infection (hpi) but otherwise began to wane at 72 hpi thereafter. With the treatment of viral DNA synthesis inhibitors, the pUL56 expression was significantly reduced, featuring the dynamics of a late (γ)-gene product. By confocal imaging, pUL56 was found to reside in the Golgi compartment. Both the L-domain motifs and the C-terminal tail-anchored transmembrane were essential for its intracellular localization. Noticeably, pUL56 co-localized with a truncated mutant of the chicken Nedd4-like family protein harboring only the WW domains; however, co-immunoprecipitation assay established no direct interaction between them, and the ectopic expression of pUL56 did not alter the abundance of endogenous Nedd4-like protein. Overall, the present study provides a caveat that the pUL56 homologues of different herpesviruses with structural similarities might vary in expression patterns and probably in functional consequences. For this reason, further investigation should be encouraged to focus on the potential association between UL56 gene and MDV pathogenesis in the context of engineered viral mutants.
    Keywords DNA replication ; Mardivirus ; T-cell lymphoma ; amino acids ; chick embryos ; chickens ; fibroblasts ; genes ; mammals ; mutants ; pathogenesis ; precipitin tests ; quantitative polymerase chain reaction ; research ; ubiquitin-protein ligase ; ubiquitination ; virulence ; viruses
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2022.198741
    Database NAL-Catalogue (AGRICOLA)

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