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Article: Comparison of Hemodynamic and Cerebral Oxygenation Responses during Exercise between Normal-Weight and Overweight Men.

Wang, Szu-Hui / Lin, Hui-Ling / Huang, Chung-Chi / Chen, Yen-Huey

2023 Volume 11, Issue 6

Abstract: Obesity has negative impacts on cardiovascular function and may increase cerebrovascular complications during exercise. We compared hemodynamic and cerebral oxygen changes during high-intensity exercise between overweight (OW) and normal-weight (NW) ... ...

Abstract	Obesity has negative impacts on cardiovascular function and may increase cerebrovascular complications during exercise. We compared hemodynamic and cerebral oxygen changes during high-intensity exercise between overweight (OW) and normal-weight (NW) individuals. Eighteen NW and fourteen OW male individuals performed high-intensity (70% of peak oxygen uptake, VO
Language	English
Publishing date	2023-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11060923
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of Hemodynamic and Cerebral Oxygenation Responses during Exercise between Normal-Weight and Overweight Men

Szu-Hui Wang / Hui-Ling Lin / Chung-Chi Huang / Yen-Huey Chen

Healthcare, Vol 11, Iss 923, p

2023 Volume 923

Abstract	Obesity has negative impacts on cardiovascular function and may increase cerebrovascular complications during exercise. We compared hemodynamic and cerebral oxygen changes during high-intensity exercise between overweight (OW) and normal-weight (NW) individuals. Eighteen NW and fourteen OW male individuals performed high-intensity (70% of peak oxygen uptake, VO 2 peak) cycling exercises for 30 min. Hemodynamics were measured using a bioelectrical impedance device, and cerebral oxygenation status was measured using a near-infrared spectrophotometer during and after exercise. The VO 2 peak of NW individuals was significantly higher than that of OW individuals (41.3 ± 5.7 vs. 30.0 ± 5.0 mL/min/kg, respectively; p < 0.05). During the 30 min exercise, both groups exhibited an increase in oxygenated hemoglobin (O 2 Hb) ( p < 0.001), deoxygenated hemoglobin ( p < 0.001), and cardiac output with increasing time. Post-exercise, cardiac output and systemic vascular resistance were significantly higher in the OW group than in the NW group ( p < 0.05). The O 2 Hb in the NW group was significantly higher at post-exercise times of 20 min (13.9 ± 7.0 μmol/L) and 30 min (12.3 ± 8.7 μmol/L) than that in the OW group (1.0 ± 13.1 μmol/L and 0.6 ± 10.0 μmol/L, respectively; p = 0.024 vs. 0.023, respectively). OW participants demonstrated lower cerebral oxygenation and higher vascular resistance in the post-exercise phase than non-OW subjects. These physiological responses should be considered while engaging OW and obese individuals in vigorous exercise.
Keywords	obesity ; exercise ; cerebral oxygenation ; hemodynamics ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Current and novel antiviral strategies for influenza infection.

Yen, Hui-Ling

Current opinion in virology

2016 Volume 18, Page(s) 126–134

Abstract: Influenza A and B viruses are major causes for respiratory infections in children and adults. Viral and host factors determine clinical manifestations which range from self-resolving uncomplicated infections, severe viral or bacterial secondary pneumonia, ...

Abstract	Influenza A and B viruses are major causes for respiratory infections in children and adults. Viral and host factors determine clinical manifestations which range from self-resolving uncomplicated infections, severe viral or bacterial secondary pneumonia, to death. Emergence of transmissible resistant variants and time-dependent effectiveness are the major challenges for the currently approved antivirals, M2 ion channel blockers and neuraminidase (NA) inhibitors. Favipiravir that inhibits the RNA-dependent RNA polymerase of multiple RNA viruses is approved in Japan against influenza strains resistant to available antivirals. With expanded knowledge on viral nucleoprotein (NP) and polymerase structures, novel small molecule inhibitors targeting NP oligomer formation, PA endonuclease domain, and the PB2 cap-binding domain are being developed. Combination therapy with different antiviral compounds or with host immune response modulators may further benefit clinical outcomes.
MeSH term(s)	Amides/therapeutic use ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Drug Resistance, Viral ; Drug Therapy, Combination ; Enzyme Inhibitors/therapeutic use ; Humans ; Influenza A virus/drug effects ; Influenza B virus/drug effects ; Influenza, Human/drug therapy ; Influenza, Human/therapy ; Influenza, Human/virology ; Neuraminidase/antagonists & inhibitors ; Nucleoproteins/metabolism ; Pyrazines/therapeutic use ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/therapy ; Virus Replication/drug effects
Chemical Substances	Amides ; Antiviral Agents ; Enzyme Inhibitors ; Nucleoproteins ; Pyrazines ; Neuraminidase (EC 3.2.1.18) ; favipiravir (EW5GL2X7E0)
Language	English
Publishing date	2016-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2611378-8
ISSN	1879-6265 ; 1879-6257
ISSN (online)	1879-6265
ISSN	1879-6257
DOI	10.1016/j.coviro.2016.05.004
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Article: The Impact of the COVID-19 Pandemic on Orthodontic Adult Patients' Characteristics and Decision on Orthodontic Appliance.

Kuo, Yun-Yu / Fang, Jason Chen-Chieh / Wang, I-Kuan / Huang, Chiung-Shing / Chen, Hui-Ling / Yen, Tzung-Hai

Journal of multidisciplinary healthcare

2024 Volume 17, Page(s) 1847–1855

Abstract: Purpose: There is an overall paucity of data examining the specific details of orthodontic patients' patterns or orthodontic service disruptions possibly influenced by COVID-19 pandemic. Therefore, this study aimed to explore the impact of the COVID-19 ... ...

Abstract	Purpose: There is an overall paucity of data examining the specific details of orthodontic patients' patterns or orthodontic service disruptions possibly influenced by COVID-19 pandemic. Therefore, this study aimed to explore the impact of the COVID-19 pandemic on orthodontic clinic disruption regarding the change in adult patients' characteristics and decisions of orthodontic treatment devices. Patients and methods: A retrospective sample of 311 patients receiving orthodontic treatment from 2018 to 2022 were collected and divided into two groups: before (n = 167) and during (n = 144) the COVID-19 pandemic. Demographics, dental indices, the index of complexity outcome and need (ICON), and the degree of treatment difficulty were analyzed. Results: There were fewer students among patients during the COVID-19 pandemic than before (24.5% versus 35.9%, P = 0.036). Compared with patients before the pandemic, more patients selected ceramic brackets or Invisalign during the pandemic (P = 0.022). There were higher percentage of class I dental malocclusions among patients during than before the COVID-19 pandemic (P = 0.044). Moreover, the ICON score and the score of the degree of treatment difficulty were both significantly lower for patients during than before the COVID-19 pandemic (63.9±14.0 versus 58.3±15.3, P=0.001 and 7.4±2.6 versus 6.8±2.6, P=0.049, respectively). Conclusion: The COVID-19 pandemic influenced the characteristics and decisions of orthodontic patients. Those who still came to the orthodontic clinic despite the COVID-19 outbreak may have been those with less malocclusion severity and treatment difficulty. Besides, during the time of covid-19 pandemic, more patients chose ceramic bracket and Invisalign as their orthodontic treatment device rather than conventional or self-ligating metal brackets.
Language	English
Publishing date	2024-04-24
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2453343-9
ISSN	1178-2390
ISSN	1178-2390
DOI	10.2147/JMDH.S456588
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Article ; Online: Cross-Reactive Antibody Responses to Coronaviruses Elicited by SARS-CoV-2 Infection or Vaccination.

Lee, Richard S H / Cheng, Samuel M S / Zhao, Jin / Tsoi, Annie Y S / Lau, Kaman K M / Chan, CoCo H C / Li, John K C / Hui, David S C / Peiris, Malik / Yen, Hui-Ling

Influenza and other respiratory viruses

2024 Volume 18, Issue 5, Page(s) e13309

Abstract: Background: The newly emerged SARS-CoV-2 possesses shared antigenic epitopes with other human coronaviruses. We investigated if COVID-19 vaccination or SARS-CoV-2 infection may boost cross-reactive antibodies to other human coronaviruses.: Methods: ... ...

Abstract	Background: The newly emerged SARS-CoV-2 possesses shared antigenic epitopes with other human coronaviruses. We investigated if COVID-19 vaccination or SARS-CoV-2 infection may boost cross-reactive antibodies to other human coronaviruses. Methods: Prevaccination and postvaccination sera from SARS-CoV-2 naïve healthy subjects who received three doses of the mRNA vaccine (BioNTech, BNT) or the inactivated vaccine (CoronaVac, CV) were used to monitor the level of cross-reactive antibodies raised against other human coronaviruses by enzyme-linked immunosorbent assay. In comparison, convalescent sera from COVID-19 patients with or without prior vaccination history were also tested. Pseudoparticle neutralization assay was performed to detect neutralization antibody against MERS-CoV. Results: Among SARS-CoV-2 infection-naïve subjects, BNT or CV significantly increased the anti-S2 antibodies against Betacoronaviruses (OC43 and MERS-CoV) but not Alphacoronaviruses (229E). The prevaccination antibody response to the common cold human coronaviruses did not negatively impact the postvaccination antibody response to SARS-CoV-2. Cross-reactive antibodies that binds to the S2 protein of MERS-CoV were similarly detected from the convalescent sera of COVID-19 patients with or without vaccination history. However, these anti-S2 antibodies do not possess neutralizing activity in MERS-CoV pseudoparticle neutralization tests. Conclusions: Our results suggest that SARS-CoV-2 infection or vaccination may potentially modulate population immune landscape against previously exposed or novel human coronaviruses. The findings have implications for future sero-epidemiological studies on MERS-CoV.
MeSH term(s)	Humans ; Cross Reactions/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/prevention & control ; SARS-CoV-2/immunology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/blood ; Adult ; Male ; Female ; Vaccination ; Middle Aged ; Vaccines, Inactivated/immunology ; Vaccines, Inactivated/administration & dosage ; Neutralization Tests ; Middle East Respiratory Syndrome Coronavirus/immunology ; Young Adult ; mRNA Vaccines/immunology
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Antibodies, Neutralizing ; Vaccines, Inactivated ; mRNA Vaccines
Language	English
Publishing date	2024-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.13309
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Article: Adjuvant Chemotherapy for Pathological Node-Positive Disease in Squamous Cell Carcinoma of the Esophagus after Neoadjuvant Chemoradiotherapy Plus Surgery.

Lin, Jing-Wei / Li, Chuan / Yeh, Hui-Ling / Chuang, Cheng-Yen / Chen, Chien-Chih

Journal of personalized medicine

2022 Volume 12, Issue 8

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12081252
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Article: Professional Accountability of Caring for Patients with COVID-19: A Phenomenographic Study.

Chen, Li-Chin / Yeh, Shu-Ling / Lee, Hui-Ling / Lin, Chun-Chih / Goopy, Suzanne / Han, Chin-Yen

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 16

Abstract: The purpose of this study was to explore nurses' care experiences for COVID-19 patients during the pandemic in Taiwan. The qualitative approach of phenomenography was used. Thirty-four nurses were recruited from two assigned hospitals in which COVID-19 ... ...

Abstract	The purpose of this study was to explore nurses' care experiences for COVID-19 patients during the pandemic in Taiwan. The qualitative approach of phenomenography was used. Thirty-four nurses were recruited from two assigned hospitals in which COVID-19 patients were treated in Taiwan from July to May 2021. The method of data collection in the study involved a semi-structured interview and drawing. Interviews were audio-recorded and transcribed verbatim. Phenomenographic analysis was used to analyze the qualitative data. Four categories of description of experiences of caring for COVID-19 patients were identified: facing uncountable stresses from all sides, strict implementation of infection control interventions to provide safe care, confronting ethical dilemmas and making difficult decisions, and reflecting on the meaning of care in nursing. Professional accountability was the core theme found to represent the central meaning of nurses caring for COVID-19 patients. Nurses were under enormous stress while caring for COVID-19 patients during the pandemic and were negatively affected physically, psychologically, and socially. Professional accountability in caring for COVID-19 patients can be enhanced through adequate support from nursing managers and by in-service training designed to update knowledge and skills related to infection control intervention.
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11162269
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Article ; Online: Adjuvant Chemotherapy for Pathological Node-Positive Disease in Squamous Cell Carcinoma of the Esophagus after Neoadjuvant Chemoradiotherapy Plus Surgery

Jing-Wei Lin / Chuan Li / Hui-Ling Yeh / Cheng-Yen Chuang / Chien-Chih Chen

Journal of Personalized Medicine, Vol 12, Iss 8, p

2022 Volume 1252

Abstract: Purpose: The purpose of the present study is to determine the impact on survival using adjuvant chemotherapy on patients with locally advanced esophageal cancer. Materials and Methods: From 2007 to 2016, we enrolled 127 locally advanced esophageal ... ...

Abstract	Purpose: The purpose of the present study is to determine the impact on survival using adjuvant chemotherapy on patients with locally advanced esophageal cancer. Materials and Methods: From 2007 to 2016, we enrolled 127 locally advanced esophageal squamous cell carcinoma patients treated with combined neoadjuvant chemoradiotherapy (nCRT) and surgery. For patients with the pathological residual primary disease (pT+) and/or residual node disease (pN+) after nCRT, adjuvant chemotherapy was also given after consideration of the toxicity of nCRT, patient performance, and/or comorbidity. The regimen of adjuvant chemotherapy was cisplatin 20 mg/m 2 /day and 5-fluorouracil 800 mg/m 2 /day on days 1 through 4 and 22 through 25. The primary endpoint was overall survival (OS). Results: From a total of 127 patients, 26 of them (20.5%) received adjuvant chemotherapy. In the multivariate analysis, pN+ diseases were independently associated with poor OS (hazard ratio (HR): 4.117, 95% confidence interval (CI): 1.366–12.404; p = 0.012). For those with pN+ diseases, their 5-year OS was 36.4% in the follow-up arm compared with 45.8% in the adjuvant chemotherapy arm ( p = 0.094). Conclusions: Pathologic node-positive disease is associated with poor OS in locally advanced esophagus cancer patients after combined treatments with nCRT and surgery. Adjuvant chemotherapy appeared to have improved OS in pathologic node-positive diseases.
Keywords	adjuvant chemotherapy ; esophageal cancer ; squamous cell carcinoma ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rapid microwave synthesis of MOF microrods: Dispersive SPE coupled with UHPLC-MS/MS to determine fluoroquinolones in honey.

Jung, Wei-Ting / Hsieh, Yi-Hsuan / Kuo, Yen-Jung / Yu, Yuan-Hsiang / Liu, Yen-Hsiang / Lu, Kuang-Lieh / Lee, Hui-Ling

Talanta

2023 Volume 263, Page(s) 124733

Abstract: A novel sorbent Cu-S metal-organic framework (MOF) microrods was prepared for dispersive solid-phase extraction via microwave synthesis and used to determine 12 fluoroquinolones (FQs) in honey samples employing ultrahigh-performance liquid chromatography- ...

Abstract	A novel sorbent Cu-S metal-organic framework (MOF) microrods was prepared for dispersive solid-phase extraction via microwave synthesis and used to determine 12 fluoroquinolones (FQs) in honey samples employing ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The best extraction efficiency was achieved by optimizing sample pH, sorbent quantity, eluent type/volume, and extraction and elution time. The proposed MOF exhibits advantages such as rapid synthesis time (20 min) and outstanding adsorption ability toward zwitterionic FQs. These advantages can be attributed to multiple interactions, including hydrogen bonding, π-π interaction, and hydrophobic interaction. The limits of detection of analytes were 0.005-0.045 ng g
MeSH term(s)	Fluoroquinolones/analysis ; Chromatography, High Pressure Liquid/methods ; Metal-Organic Frameworks ; Tandem Mass Spectrometry/methods ; Honey/analysis ; Microwaves ; Solid Phase Extraction/methods
Chemical Substances	Fluoroquinolones ; Metal-Organic Frameworks
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.124733
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Article ; Online: Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

Pavithra Daulagala / Samuel M.S. Cheng / Alex Chin / Leo L.H. Luk / Kathy Leung / Joseph T. Wu / Leo L.M. Poon / Malik Peiris / Hui-Ling Yen

Emerging Infectious Diseases, Vol 30, Iss 1, Pp 168-

2024 Volume 171

Abstract: We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% ...

Abstract	We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.
Keywords	influenza ; viruses ; influenza A(H5N1) ; influenza A(H1N1)pdm09 ; respiratory infections ; clade 2.3.4.4.b ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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