Article ; Online: Cell Death Pathways Drive Necroinflammation during Acute Kidney Injury.
2018 Volume 140, Issue 2, Page(s) 144–147
Abstract: Renal tubules represent an intercellular unit and function as a syncytium. When acute tubular necrosis was first visualized to occur through a process of synchronized regulated necrosis (SRN) in handpicked primary renal tubules, it became obvious that ... ...
Abstract | Renal tubules represent an intercellular unit and function as a syncytium. When acute tubular necrosis was first visualized to occur through a process of synchronized regulated necrosis (SRN) in handpicked primary renal tubules, it became obvious that SRN actually promotes nephron loss. This realization adds to our current understanding of acute kidney injury (AKI)-chronic kidney disease (CKD) transition and argues for the prevention of AKI episodes to prevent CKD progression. Because SRN is triggered by necroptosis and executed by ferroptosis, 2 recently identified signaling pathways of regulated necrosis, a combination therapy employing necrostatins and ferrostatins may be beneficial for protection against nephron loss. Clinical trials in AKI and during the process of kidney transplantation are now required to prevent SRN. Additionally, necrotic cell death drives autoimmunity and necroinflammation and therefore represents a therapeutic target even for the prevention of antibody-mediated rejection of allografts years after the transplantation process. |
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MeSH term(s) | Acute Kidney Injury/pathology ; Apoptosis ; Cell Death ; Disease Progression ; Humans ; Kidney/pathology ; Necrosis ; Nephritis/pathology |
Language | English |
Publishing date | 2018-06-29 |
Publishing country | Switzerland |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 207121-6 |
ISSN | 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766 |
ISSN (online) | 2235-3186 ; 1423-0186 |
ISSN | 1660-8151 ; 0028-2766 |
DOI | 10.1159/000490807 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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