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  1. Article: Small coordination complexes in tumor imaging.

    Abrams, M J

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1991  Volume 32, Issue 5, Page(s) 849–850

    MeSH term(s) Humans ; Neoplasms/diagnostic imaging ; Organotechnetium Compounds/chemistry ; Radionuclide Imaging ; Succimer/chemistry ; Technetium Tc 99m Dimercaptosuccinic Acid
    Chemical Substances Organotechnetium Compounds ; Technetium Tc 99m Dimercaptosuccinic Acid (494JNQ8L28) ; Succimer (DX1U2629QE)
    Language English
    Publishing date 1991-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  2. Article: The chemical identity of pentavalent technetium-DMSA and editorial: small coordination complexes in tumor imaging.

    Blower, P J / Singh, J / Clarke, S E

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1992  Volume 33, Issue 3, Page(s) 469

    MeSH term(s) Chromatography, Gel ; Molecular Weight ; Organotechnetium Compounds/chemistry ; Succimer/chemistry ; Technetium Tc 99m Dimercaptosuccinic Acid
    Chemical Substances Organotechnetium Compounds ; Technetium Tc 99m Dimercaptosuccinic Acid (494JNQ8L28) ; Succimer (DX1U2629QE)
    Language English
    Publishing date 1992-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Article ; Online: CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors.

    Hartlapp, Ingo / Hartrampf, Philipp E / Serfling, Sebastian E / Wild, Vanessa / Weich, Alexander / Rasche, Leo / Roth, Sabine / Rosenwald, Andreas / Mihatsch, Patrick W / Hendricks, Anne / Wiegering, Armin / Wiegering, Verena / Hänscheid, Heribert / Schirbel, Andreas / Werner, Rudolf A / Buck, Andreas K / Wester, Hans-Jürgen / Einsele, Hermann / Kunzmann, Volker /
    Lapa, Constantin / Kortüm, K Martin

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 9, Page(s) 1424–1430

    Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare, radiosensitive, yet difficult-to-treat ... CXCR4)-directed imaging and endoradiotherapy in DSRCT. ...

    Abstract Desmoplastic small round cell tumor (DSRCT) is a rare, radiosensitive, yet difficult-to-treat sarcoma subtype affecting predominantly male adolescents. Extensive intraperitoneal seeding is common and requires multimodal management. With no standard therapy established, the prognosis remains poor, and new treatment options are needed. We demonstrate the clinical potential of C-X-C motif chemokine receptor 4 (CXCR4)-directed imaging and endoradiotherapy in DSRCT.
    MeSH term(s) Adolescent ; Humans ; Male ; Female ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Hematopoietic Stem Cell Transplantation ; Gallium Radioisotopes ; Desmoplastic Small Round Cell Tumor/diagnostic imaging ; Desmoplastic Small Round Cell Tumor/therapy ; Transplantation, Autologous ; Peptides, Cyclic ; Coordination Complexes ; Receptors, CXCR4/metabolism
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes ; Peptides, Cyclic ; Coordination Complexes ; Receptors, CXCR4 ; CXCR4 protein, human
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.265464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [68Ga]Pentixafor-PET/CT for imaging of chemokine receptor 4 expression in small cell lung cancer--initial experience.

    Lapa, Constantin / Lückerath, Katharina / Rudelius, Martina / Schmid, Jan-Stefan / Schoene, Alexander / Schirbel, Andreas / Samnick, Samuel / Pelzer, Theo / Buck, Andreas K / Kropf, Saskia / Wester, Hans-Jürgen / Herrmann, Ken

    Oncotarget

    2016  Volume 7, Issue 8, Page(s) 9288–9295

    Abstract: ... cancer. This study investigated the feasibility of CXCR4-directed imaging of small cell lung cancer (SCLC ... Chemokine receptor CXCR4 is a key factor for tumor growth and metastasis in several types of human ... lesions with significantly higher tumor-to-background ratios than SSTR-PET. Two patients who were positive ...

    Abstract Chemokine receptor CXCR4 is a key factor for tumor growth and metastasis in several types of human cancer. This study investigated the feasibility of CXCR4-directed imaging of small cell lung cancer (SCLC) with positron emission tomography/computed tomography (PET/CT) using the radiolabelled chemokine ligand [68Ga]Pentixafor. 10 patients with primarily diagnosed (n=3) or pre-treated (n=7) SCLC (n=9) or large cell neuroendocrine carcinoma of the lung (LCNEC, n=1) underwent [68Ga]Pentixafor-PET/CT. 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG, n=6) and/or somatostatin receptor (SSTR)-directed PET/CT with [68Ga]DOTATOC (n=5) and immunohistochemistry (n=10) served as standards of reference. CXCR4-PET was positive in 8/10 patients and revealed more lesions with significantly higher tumor-to-background ratios than SSTR-PET. Two patients who were positive on [18F]FDG-PET were missed by CXCR4-PET, in the remainder [68Ga]Pentixafor detected an equal (n=2) or higher (n=2) number of lesions. CXCR4 expression of tumor lesions could be confirmed by immunohistochemistry. Non-invasive imaging of CXCR4 expression in SCLC is feasible. [68Ga]Pentixafor as a novel PET tracer might serve as readout for confirmation of CXCR4 expression as prerequisite for potential CXCR4-directed treatment including receptor-radio(drug)peptide therapy.
    MeSH term(s) Adult ; Aged ; Coordination Complexes/pharmacology ; Female ; Fluorodeoxyglucose F18/pharmacology ; Gallium Radioisotopes/pharmacology ; Humans ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Octreotide/analogs & derivatives ; Octreotide/pharmacology ; Peptides, Cyclic/pharmacology ; Positron Emission Tomography Computed Tomography/methods ; Receptors, CXCR4/analysis ; Receptors, Somatostatin/analysis ; Small Cell Lung Carcinoma/diagnostic imaging
    Chemical Substances 68Ga-pentixafor ; CXCR4 protein, human ; Coordination Complexes ; Gallium Radioisotopes ; Peptides, Cyclic ; Receptors, CXCR4 ; Receptors, Somatostatin ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Octreotide (RWM8CCW8GP) ; Edotreotide (U194AS08HZ)
    Language English
    Publishing date 2016-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.7063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular Imaging of Chemokine Receptor CXCR4 in Non-Small Cell Lung Cancer Using 68Ga-Pentixafor PET/CT: Comparison With 18F-FDG.

    Derlin, Thorsten / Jonigk, Danny / Bauersachs, Johann / Bengel, Frank M

    Clinical nuclear medicine

    2016  Volume 41, Issue 4, Page(s) e204–5

    Abstract: ... a novel CXCR4-targeted probe for PET imaging of CXCR4-positive tumors and holds promise for tumor staging ... non-small cell lung cancer. Immunohistochemistry confirmed that CXCR4 was highly expressed on tumor cells. 68Ga-Pentixafor is ...

    Abstract We report the case of a 62-year-old woman with a history of ST-elevation myocardial infarction who underwent 68Ga-Pentixafor PET/CT for characterization of postinfarct myocardial inflammation. 68Ga-Pentixafor PET/CT incidentally demonstrated marked CXCR4 expression in a space-occupying lesion in the right upper lobe. Corresponding 18F-FDG PET/CT showed increased metabolism, and subsequent biopsy revealed non-small cell lung cancer. Immunohistochemistry confirmed that CXCR4 was highly expressed on tumor cells. 68Ga-Pentixafor is a novel CXCR4-targeted probe for PET imaging of CXCR4-positive tumors and holds promise for tumor staging and prognostic stratification. CXCR4-targeted radionuclide therapy represents a therapy option in metastasized diseases.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Coordination Complexes ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms/diagnostic imaging ; Middle Aged ; Multimodal Imaging ; Peptides, Cyclic ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed
    Chemical Substances 68Ga-pentixafor ; Coordination Complexes ; Peptides, Cyclic ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Case Reports ; Comparative Study ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000001092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  6. Article ; Online: Noninvasive positron emission tomography imaging of cell death using a novel small-molecule probe, (18)F labeled bis(zinc(II)-dipicolylamine) complex.

    Wang, Hongliang / Tang, Xiaolan / Tang, Ganghua / Huang, Tingting / Liang, Xiang / Hu, Kongzhen / Deng, Huaifu / Yi, Chang / Shi, Xinchong / Wu, Kening

    Apoptosis : an international journal on programmed cell death

    2013  Volume 18, Issue 8, Page(s) 1017–1027

    Abstract: ... imaging of tumor treated with a chemical agent. The in vitro cell stain studies revealed that fluorescent ... intestine within 90 min postinjection was also found. For the PET imaging, significantly higher tumor uptake ... mice than that in the untreated tumor-model mice, while a slightly decreased tumor uptake of (18)F-FDG ...

    Abstract The synthetic bis(zinc(II)-dipicolylamine) (DPAZn2) coordination complexes are known to have a high specific and selective affinity to target the exposed phosphatidylserine (PS) on the surface of dead and dying cells. An (18)F-labeled DPAZn2 complex (4-(18)F-Fluoro-benzoyl-bis(zinc(II)-dipicolylamine), (18)F-FB-DPAZn2) as positron emission tomography (PET) tracer was developed and evaluated for in vivo imaging of tumor treated with a chemical agent. The in vitro cell stain studies revealed that fluorescent DPAZn2 complexes (Dansyl-DPAZn2) stained the same cells (apoptotic and necrotic cells) as fluorescein isothiocyanate (FITC) labeled Annexin V (FITC-Annexin V). The radiosynthesis of (18)F-FB-DPAZn2 was achieved through the amidation the precursor bis(2,2'-dipicolylamine) derivative (DPA2) with the prosthetic group N-succinimidyl-4-[(18)F]-fluorobenzoate ((18)F-SFB) and chelation with zinc nitrate. In the biodistribution study, the fast clearance of (18)F-FB-DPAZn2 from blood and kidney was observed and high uptake in liver and intestine within 90 min postinjection was also found. For the PET imaging, significantly higher tumor uptake of (18)F-FB-DPAZn2 was observed in the adriamycin (ADM)-treated Hepa1-6 hepatocellular carcinoma-bearing mice than that in the untreated tumor-model mice, while a slightly decreased tumor uptake of (18)F-FDG was found in the ADM-treated tumor-bearing mice. The results indicate that (18)F-FB-DPAZn2 has the similar capability of apoptosis detection as FITC-Annexin V and seems to be a potential PET tracer for noninvasive evaluation and monitoring of anti-tumor chemotherapy. The high uptake of (18)F-FB-DPAZn2 in the abdomen needs to optimize the structure for improving its pharmacokinetics characteristics in the future work.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Fluorine Radioisotopes ; Humans ; Mice ; Molecular Probes ; Neoplasm Transplantation ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/physiopathology ; Organometallic Compounds ; Picolinic Acids ; Positron-Emission Tomography/instrumentation ; Positron-Emission Tomography/methods ; Radionuclide Imaging/instrumentation ; Radionuclide Imaging/methods ; Radiopharmaceuticals
    Chemical Substances Antineoplastic Agents ; Fluorine Radioisotopes ; Molecular Probes ; Organometallic Compounds ; Picolinic Acids ; Radiopharmaceuticals ; bis-dipicolylamine-Zinc(II)
    Language English
    Publishing date 2013-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-013-0852-4
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