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  1. Article ; Online: Avascular necrosis as a part of 'long COVID-19'.

    Agarwala, Sanjay R / Vijayvargiya, Mayank / Pandey, Prashant

    BMJ case reports

    2021  Volume 14, Issue 7

    Abstract: 'Long COVID-19' can affect different body systems. At present, avascular necrosis (AVN ... as a sequalae of 'long COVID-19' has yet not been documented. By large-scale use of life-saving corticosteroids ... in COVID-19 cases, we anticipate that there will be a resurgence of AVN cases. We report a series of three ...

    Abstract 'Long COVID-19' can affect different body systems. At present, avascular necrosis (AVN) as a sequalae of 'long COVID-19' has yet not been documented. By large-scale use of life-saving corticosteroids in COVID-19 cases, we anticipate that there will be a resurgence of AVN cases. We report a series of three cases in which patients developed AVN of the femoral head after being treated for COVID-19 infection. The mean dose of prednisolone used in these cases was 758 mg (400-1250 mg), which is less than the mean cumulative dose of around 2000 mg steroid, documented in the literature as causative for AVN. Patients were symptomatic and developed early AVN presentation at a mean of 58 days after COVID-19 diagnosis as compared with the literature which shows that it generally takes 6 months to 1 year to develop AVN post steroid exposure.
    MeSH term(s) COVID-19/complications ; COVID-19 Testing ; Femur Head Necrosis ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-242101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Avascular Necrosis of the Hip after the COVID-19 Pandemic.

    Sinha, Priti R / Mallick, Nitin / Sahu, Ramjee L

    Journal of pharmacy & bioallied sciences

    2023  Volume 15, Issue Suppl 1, Page(s) S661–S664

    Abstract: Background and objectives: It is clear that COVID-19 can have a wide range of effects on the body ... may impact the hip bone and joint tissue. However, it is known that COVID-19 can cause inflammation and ... admitted to the hospital due to COVID-19 and later complained of hip pain. Magnetic resonance imaging (MRI ...

    Abstract Background and objectives: It is clear that COVID-19 can have a wide range of effects on the body, and the musculoskeletal system is no exception. Studies are ongoing to better understand how the virus may impact the hip bone and joint tissue. However, it is known that COVID-19 can cause inflammation and damage to various parts of the body, including the bones and joints, which could lead to pain, stiffness, and other symptoms.
    Materials and methods: A retrospective analysis is done with ten patients admitted to the hospital due to COVID-19 and later complained of hip pain. Magnetic resonance imaging (MRI) was performed on the patients, and it was found that they had degenerative changes characterized by avascular necrosis (AVN) of the head of the femur. One of the patients had a history of previous surgery on the femur with a plate and screws and was doing well but developed AVN after contracting COVID-19.
    Results: Observation among these groups shows a strong association between the history of COVID-19, high levels of IgG antibodies, the presence of joint abnormalities, and moderately severe symptoms. There is no evidence of identifying autoimmune, degenerative, or AVN diseases. This set of patients responded positively to supportive therapy and anti-inflammatory drugs used in empirical treatment, which subsided joint pain and acute inflammatory symptoms.
    Conclusions: It has been determined that there are significant musculoskeletal complications in COVID-19 patients, including AVN, which may be caused by the high use of steroids and microembolism leading to bone necrosis. Therefore, further studies and long-term follow-up are recommended.
    Language English
    Publishing date 2023-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_87_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Necrosis avascular de cadera secundaria a COVID de larga duración.

    García-Dobarganes-Barlow, F E / Valadez-Soto, J M / Saavedra-Islas, N / García-Romo, V M / Mata-Coronado, J / Villavicencio-Ocampo, E / Encalada-Díaz, M I

    Acta ortopedica mexicana

    2024  Volume 38, Issue 1, Page(s) 48–51

    Abstract: Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue ... for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence ... of avascular necrosis in his left hip, before the administration of corticosteroids for the treatment of COVID ...

    Title translation Avascular necrosis of the hip secondary to long-standing COVID.
    Abstract Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence of symptoms beyond 12 weeks from the onset of the disease. Corticosteroids are part of the treatment in this period with good results in controlling the disease; however, it is a predisposing factor for the development of avascular necrosis. We present a clinic case of a young man of 39 years old with diagnosis of avascular necrosis in his left hip, before the administration of corticosteroids for the treatment of COVID-19. There is a lack of consensus about the dosage and duration of steroids required to develop avascular necrosis. Some authors have reported that cumulative dose of 2,000 mg prednisone (or its equivalent) was required for avascular necrosis development. For patients with advanced avascular necrosis stages total hip arthroplasty is an attractive option with excellent outcomes in terms of pain relief and survivorship.
    MeSH term(s) Humans ; Male ; COVID-19/complications ; Adult ; Femur Head Necrosis/etiology ; Femur Head Necrosis/surgery ; Time Factors ; Arthroplasty, Replacement, Hip ; Glucocorticoids/therapeutic use ; Glucocorticoids/administration & dosage
    Chemical Substances Glucocorticoids
    Language Spanish
    Publishing date 2024-04-24
    Publishing country Mexico
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 2205424-8
    ISSN 2306-4102
    ISSN 2306-4102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Avascular necrosis of the hip after the COVID-19 pandemic

    Priti R Sinha / Nitin Mallick / Ramjee L Sahu

    Journal of Pharmacy and Bioallied Sciences, Vol 15, Iss 5, Pp 661-

    2023  Volume 664

    Abstract: Background and Objectives: It is clear that COVID-19 can have a wide range of effects on the body ... may impact the hip bone and joint tissue. However, it is known that COVID-19 can cause inflammation and ... to the hospital due to COVID-19 and later complained of hip pain. Magnetic resonance imaging (MRI) was performed ...

    Abstract Background and Objectives: It is clear that COVID-19 can have a wide range of effects on the body, and the musculoskeletal system is no exception. Studies are ongoing to better understand how the virus may impact the hip bone and joint tissue. However, it is known that COVID-19 can cause inflammation and damage to various parts of the body, including the bones and joints, which could lead to pain, stiffness, and other symptoms. Materials and Methods: A retrospective analysis is done with ten patients admitted to the hospital due to COVID-19 and later complained of hip pain. Magnetic resonance imaging (MRI) was performed on the patients, and it was found that they had degenerative changes characterized by avascular necrosis (AVN) of the head of the femur. One of the patients had a history of previous surgery on the femur with a plate and screws and was doing well but developed AVN after contracting COVID-19. Results: Observation among these groups shows a strong association between the history of COVID-19, high levels of IgG antibodies, the presence of joint abnormalities, and moderately severe symptoms. There is no evidence of identifying autoimmune, degenerative, or AVN diseases. This set of patients responded positively to supportive therapy and anti-inflammatory drugs used in empirical treatment, which subsided joint pain and acute inflammatory symptoms. Conclusions: It has been determined that there are significant musculoskeletal complications in COVID-19 patients, including AVN, which may be caused by the high use of steroids and microembolism leading to bone necrosis. Therefore, further studies and long-term follow-up are recommended.
    Keywords avascular necrosis bone ; corticosteroids ; osteonecrosis ; sars-cov-2 infections ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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