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  1. Article: Outcomes of COVID-19 in Hematopoietic Stem Cell Transplant Recipients: Multicenter Retrospective Analysis.

    Agrawal, Narendra / Singh, Reema / Sharma, Sanjeev Kumar / Naithani, Rahul / Bhargava, Rahul / Choudhary, Dharma / Jeyaraman, Preethi / Bansal, Sachin / Doval, Divya / Khandelwal, Vipin / Bansal, Nitin / Ahmed, Rayaz / Bhurani, Dinesh

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2021  Volume 38, Issue 2, Page(s) 388–393

    Abstract: ... within a year of HSCT. We studied a cohort of 28 hematopoietic stem cell transplant recipients (male 17, M:F ... a pandemic by the World Health Organization on March 9, 2020. Hematopoietic stem-cell transplantation (HSCT ... ratio of 1.5) with COVID-19 infection from 1st June 2020, through 31st December 2020 for outcome. Fever ...

    Abstract COVID-19, caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization on March 9, 2020. Hematopoietic stem-cell transplantation (HSCT) recipients may be highly susceptible to infection and related pulmonary complications due to nascent immune systems or organ damage from treatment-related toxicities. Poor outcomes in such group of patients were linked to older age, steroid therapy at the time of COVID-19 infection, and COVID-19 infection within a year of HSCT. We studied a cohort of 28 hematopoietic stem cell transplant recipients (male 17, M:F ratio of 1.5) with COVID-19 infection from 1st June 2020, through 31st December 2020 for outcome. Fever was the most common symptom at the time of presentation in 22 (78.5%) patients. Mortality rate at Day 28 and Day 42 was found to be 4/28 (14.3%) and 7/28 (25%) respectively. Patients within one year of HSCT and severe infection had higher day 28 mortality (with
    Language English
    Publishing date 2021-07-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-021-01472-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry.

    Busca, Alessandro / Salmanton-García, Jon / Marchesi, Francesco / Farina, Francesca / Seval, Guldane Cengiz / Van Doesum, Jaap / De Jonge, Nick / Bahr, Nathan C / Maertens, Johan / Meletiadis, Joseph / Fracchiolla, Nicola S / Weinbergerová, Barbora / Verga, Luisa / Ráčil, Zdeněk / Jiménez, Moraima / Glenthøj, Andreas / Blennow, Ola / Tanase, Alina Daniela / Schönlein, Martin /
    Prezioso, Lucia / Khanna, Nina / Duarte, Rafael F / Žák, Pavel / Nucci, Marcio / Machado, Marina / Kulasekararaj, Austin / Espigado, Ildefonso / De Kort, Elizabeth / Ribera-Santa Susana, José-María / Marchetti, Monia / Magliano, Gabriele / Falces-Romero, Iker / Ilhan, Osman / Ammatuna, Emanuele / Zompi, Sofia / Tsirigotis, Panagiotis / Antoniadou, Anastasia / Zambrotta, Giovanni Paolo Maria / Nordlander, Anna / Karlsson, Linda Katharina / Hanakova, Michaela / Dragonetti, Giulia / Cabirta, Alba / Berg Venemyr, Caroline / Gräfe, Stefanie / Van Praet, Jens / Tragiannidis, Athanasios / Petzer, Verena / López-García, Alberto / Itri, Federico / Groh, Ana / Gavriilaki, Eleni / Dargenio, Michelina / Rahimli, Laman / Cornely, Oliver A / Pagano, Livio

    Frontiers in immunology

    2023  Volume 14, Page(s) 1125030

    Abstract: Background: The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT ... of death in 16% of the patients (n=53).: Conclusions: Mortality in HSCT recipients who develop COVID-19 ... the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection ...

    Abstract Background: The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT.
    Methods: This multicenter retrospective study promoted by the European Hematology Association - Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022.
    Results: The median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53).
    Conclusions: Mortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Retrospective Studies ; COVID-19/etiology ; Hematologic Diseases/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1125030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk factors and outcome of COVID-19 in patients with hematological malignancies

    José Luis Piñana / Rodrigo Martino / Irene García-García / Rocío Parody / María Dolores Morales / Gonzalo Benzo / Irene Gómez-Catalan / Rosa Coll / Ignacio De La Fuente / Alejandro Luna / Beatriz Merchán / Anabelle Chinea / Dunia de Miguel / Ana Serrano / Carmen Pérez / Carola Diaz / José Luis Lopez / Adolfo Jesús Saez / Rebeca Bailen /
    Teresa Zudaire / Diana Martínez / Manuel Jurado / María Calbacho / Lourdes Vázquez / Irene Garcia-Cadenas / Laura Fox / Ana I. Pimentel / Guiomar Bautista / Agustin Nieto / Pascual Fernandez / Juan Carlos Vallejo / Carlos Solano / Marta Valero / Ildefonso Espigado / Raquel Saldaña / Luisa Sisinni / Josep Maria Ribera / Maria Jose Jimenez / Maria Trabazo / Marta Gonzalez-Vicent / Noemí Fernández / Carme Talarn / Maria Carmen Montoya / Angel Cedillo / Anna Sureda / Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)

    Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-

    2020  Volume 16

    Abstract: ... and COVID-19 are poorly defined. Patients and methods This was a Spanish transplant group and cell ... including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n ... In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids ...

    Abstract Abstract Background Prognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defined. Patients and methods This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. Results We included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n = 65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1–93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p = 0.02). Prognostic factors identified for day 45 overall mortality (OM) by logistic regression multivariate analysis included age > 70 years [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2–3.8, p = 0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6–5.2, p < 0.0001); ECOG 3–4 (OR, 2.56, 95% CI 1.4–4.7, p = 0.003); neutropenia (< 0.5 × 109/L) (OR 2.8, 95% CI 1.3–6.1, p = 0.01); and a C-reactive protein (CRP) > 20 mg/dL (OR 3.3, 95% CI 1.7–6.4, p < 0.0001). In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2–0.89 and OR 0.31, 95% CI 0.11–0.87, respectively, p = 0.02) whereas the use of hidroxycloroquine did not show significant improvement in OM (OR 0.64, 95% CI 0.37–1.1, P = 0.1). Conclusions In most patients with hematological malignancies COVID-19 mortality was directly driven by older age, disease status, performance status, as well as by immune (neutropenia) parameters and level of inflammation (high CRP). Use of azithromycin and low dose corticosteroids may be of value in very severe COVID-19.
    Keywords Diseases of the blood and blood-forming organs ; RC633-647.5 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Subject code 610 ; 616
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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