Article ; Online: Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with
2017 Volume 9, Issue 4, Page(s) 498–507
Abstract: Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated ... selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common ... with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model ...
| Abstract | Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large-scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common, occurring in about 43% of 10,744 cancer specimens and cell lines. Consistent with p53-dependent negative selection, such lesions are underrepresented in |
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| MeSH term(s) | Cell Line, Tumor ; Gene Deletion ; Gene Expression Regulation, Neoplastic ; Humans ; Mutation ; Neoplasms/pathology ; Ribosomal Proteins/genetics ; Tumor Suppressor Protein p53/genetics | |||||
| Chemical Substances | Ribosomal Proteins ; TP53 protein, human ; Tumor Suppressor Protein p53 | |||||
| Language | English | |||||
| Publishing date | 2017-03-06 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2467145-9 | |||||
| ISSN | 1757-4684 ; 1757-4676 | |||||
| ISSN (online) | 1757-4684 | |||||
| ISSN | 1757-4676 | |||||
| DOI | 10.15252/emmm.201606660 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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