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  1. Article: Molecular Evidence of Helicobacter Pylori Infection in Prostate Tumors.

    Al-Marhoon, Mohammed S / Ouhtit, Allal / Al-Abri, Aisha O / Venkiteswaran, Krishna P / Al-Busaidi, Qassim / Mathew, Josephkunju / Al-Haddabi, Ibrahim / Shareef, Omar / Aquil, Shahid / Rahman, Khalid / Al-Hashmi, Intisar / Gupta, Ishita / Ganguly, Shyam S

    Current urology

    2015  Volume 8, Issue 3, Page(s) 138–143

    Abstract: ... evidence of the presence of H. pylori DNA in prostatic tissue of patients with BPH and PCa. It paves ... with prostate diseases were enrolled in the study. Detection of H. pylori DNA in prostate tissue from patients with BPH ... no positive sample for H. pylori, PCR combined with sequencing detected H. pylori DNA in prostate ...

    Abstract Objectives: To determine whether Helicobacter pylori (H. pylori) is detectable in both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma. Many bacteria have been found in the prostate of patients with chronic prostatitis, BPH, and PCa.
    Methods: One hundred consecutive patients with prostate diseases were enrolled in the study. Detection of H. pylori DNA in prostate tissue from patients with BPH and PCa was performed using both immunohistochemistry and PCR, and the results were confirmed by DNA sequencing. Odds ratios and the Fisher Exact test were used for the analysis of the associations between the variables.
    Results: Among the patients, 78% had BPH and 19% had PCa. While immunohistochemistry showed no positive sample for H. pylori, PCR combined with sequencing detected H. pylori DNA in prostate tissue samples from 5 patients. However, statistical analysis of the data showed that BPH and PCa are not significantly associated with the presence of H. pylori DNA in prostate tissue (odds ratio = 0.94, 95% confidence interval = 0.09-23.34, one-tailed Chi-square value = 0.660, p > 0.05). The limitation of this study was the small number of PCa patients.
    Conclusions: This study provides, for the first time, molecular evidence of the presence of H. pylori DNA in prostatic tissue of patients with BPH and PCa. It paves the way for further comprehensive studies to examine the association of H. pylori infection with BPH and PCa.
    Language English
    Publishing date 2015-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2253664-4
    ISSN 1661-7657 ; 1661-7649
    ISSN (online) 1661-7657
    ISSN 1661-7649
    DOI 10.1159/000365705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6628: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Molecular Evidence of ; Infection in Prostate Tumors

    Al-Marhoon, Mohammed S. / Ouhtit, Allal / Al-Abri, Aisha O. / Venkiteswaran, Krishna P. / Al-Busaidi, Qassim / Mathew, Josephkunju / Al-Haddabi, Ibrahim / Shareef, Omar / Aquil, Shahid / Rahman, Khalid / Al-Hashmi, Intisar / Gupta, Ishita / Ganguly, Shyam S.

    Current Urology

    2015  Volume 8, Issue 3, Page(s) 138–143

    Abstract: ... with prostate diseases were enrolled in the study. Detection of H. pylori DNA in prostate tissue from patients with BPH ... positive sample for H. pylori, PCR combined with sequencing detected H. pylori DNA in prostate tissue ... significantly associated with the presence of H. pylori DNA in prostate tissue (odds ratio = 0.94, 95 ...

    Institution Department of Surgery Department of Genetics Department of Pathology; and Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoudh, Oman
    Abstract Objectives: To determine whether Helicobacter pylori (H. pylori) is detectable in both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma. Many bacteria have been found in the prostate of patients with chronic prostatitis, BPH, and PCa. Methods: One hundred consecutive patients with prostate diseases were enrolled in the study. Detection of H. pylori DNA in prostate tissue from patients with BPH and PCa was performed using both immunohistochemistry and PCR, and the results were confirmed by DNA sequencing. Odds ratios and the Fisher Exact test were used for the analysis of the associations between the variables. Results: Among the patients, 78% had BPH and 19% had PCa. While immunohistochemistry showed no positive sample for H. pylori, PCR combined with sequencing detected H. pylori DNA in prostate tissue samples from 5 patients. However, statistical analysis of the data showed that BPH and PCa are not significantly associated with the presence of H. pylori DNA in prostate tissue (odds ratio = 0.94, 95% confidence interval = 0.09-23.34, one-tailed Chi-square value = 0.660, p > 0.05). The limitation of this study was the small number of PCa patients. Conclusions: This study provides, for the first time, molecular evidence of the presence of H. pylori DNA in prostatic tissue of patients with BPH and PCa. It paves the way for further comprehensive studies to examine the association of H. pylori infection with BPH and PCa.
    Keywords Helicobacter pylori infection ; Prostate cancer ; Benign prostate hyperplasia ; PCR
    Language English
    Publishing date 2015-09-04
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 2253664-4
    ISSN 1661-7657 ; 1661-7649
    ISSN (online) 1661-7657
    ISSN 1661-7649
    DOI 10.1159/000365705
    Database Karger publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6628: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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