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  1. Article ; Online: Correction: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.

    Annals of internal medicine

    2021  Volume 174, Issue 6, Page(s) 888

    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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  2. Article ; Online: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.

    Al-Samkari, Hanny / Gupta, Shruti / Leaf, Rebecca Karp / Wang, Wei / Rosovsky, Rachel P / Brenner, Samantha K / Hayek, Salim S / Berlin, Hanna / Kapoor, Rajat / Shaefi, Shahzad / Melamed, Michal L / Sutherland, Anne / Radbel, Jared / Green, Adam / Garibaldi, Brian T / Srivastava, Anand / Leonberg-Yoo, Amanda / Shehata, Alexandre M / Flythe, Jennifer E /
    Rashidi, Arash / Goyal, Nitender / Chan, Lili / Mathews, Kusum S / Hedayati, S Susan / Dy, Rajany / Toth-Manikowski, Stephanie M / Zhang, Jingjing / Mallappallil, Mary / Redfern, Roberta E / Bansal, Amar D / Short, Samuel A P / Vangel, Mark G / Admon, Andrew J / Semler, Matthew W / Bauer, Kenneth A / Hernán, Miguel A / Leaf, David E

    Annals of internal medicine

    2021  Volume 174, Issue 5, Page(s) 622–632

    Abstract: ... major bleeding in critically ill patients with COVID-19 and examine the observational effect ... of early therapeutic anticoagulation on survival.: Design: In a multicenter cohort study of 3239 critically ill ... to examine the observational effect of early therapeutic anticoagulation on survival. A Cox model ...

    Abstract Background: Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).
    Objective: To evaluate the incidence of venous thromboembolism (VTE) and major bleeding in critically ill patients with COVID-19 and examine the observational effect of early therapeutic anticoagulation on survival.
    Design: In a multicenter cohort study of 3239 critically ill adults with COVID-19, the incidence of VTE and major bleeding within 14 days after intensive care unit (ICU) admission was evaluated. A target trial emulation in which patients were categorized according to receipt or no receipt of therapeutic anticoagulation in the first 2 days of ICU admission was done to examine the observational effect of early therapeutic anticoagulation on survival. A Cox model with inverse probability weighting to adjust for confounding was used.
    Setting: 67 hospitals in the United States.
    Participants: Adults with COVID-19 admitted to a participating ICU.
    Measurements: Time to death, censored at hospital discharge, or date of last follow-up.
    Results: Among the 3239 patients included, the median age was 61 years (interquartile range, 53 to 71 years), and 2088 (64.5%) were men. A total of 204 patients (6.3%) developed VTE, and 90 patients (2.8%) developed a major bleeding event. Independent predictors of VTE were male sex and higher D-dimer level on ICU admission. Among the 2809 patients included in the target trial emulation, 384 (11.9%) received early therapeutic anticoagulation. In the primary analysis, during a median follow-up of 27 days, patients who received early therapeutic anticoagulation had a similar risk for death as those who did not (hazard ratio, 1.12 [95% CI, 0.92 to 1.35]).
    Limitation: Observational design.
    Conclusion: Among critically ill adults with COVID-19, early therapeutic anticoagulation did not affect survival in the target trial emulation.
    Primary funding source: None.
    MeSH term(s) Aged ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/mortality ; Blood Coagulation Disorders/virology ; COVID-19/complications ; COVID-19/mortality ; Critical Illness ; Female ; Hemorrhage/chemically induced ; Hemorrhage/mortality ; Hemorrhage/virology ; Humans ; Intensive Care Units ; Male ; Middle Aged ; SARS-CoV-2 ; Survival Rate ; United States/epidemiology ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/mortality ; Venous Thromboembolism/virology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-6739
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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