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Article ; Online: COVID-19 in a Cohort of Patients with Congenital Myasthenic Syndrome.

Alabaf, Setareh / O'Connell, Karen / Ramdas, Sithara / Beeson, David / Palace, Jacqueline

Journal of neuromuscular diseases

2021  Volume 8, Issue 6, Page(s) 1003–1005

Abstract: ... may therefore be at high risk of developing a severe disease from COVID-19. We screened 73 patients ... of confirmed COVID-19. None of the infected patients developed a severe disease, and there were no signals ... Severe Acute Respiratory Syndrome Corona Virus 2 infection and their clinical outcome. Of 73 patients, seven had history ...

Abstract Congenital Myasthenic Syndromes (CMS) are a rare group of genetic disorders of neuromuscular transmission. Some subtypes of CMS can be associated with respiratory and bulbar weakness and these patients may therefore be at high risk of developing a severe disease from COVID-19. We screened 73 patients with genetically confirmed CMS who were attending the UK national referral centre for evidence of previous Severe Acute Respiratory Syndrome Corona Virus 2 infection and their clinical outcome. Of 73 patients, seven had history of confirmed COVID-19. None of the infected patients developed a severe disease, and there were no signals that CMS alone carries a high risk of severe disease from COVID-19.
MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; Child ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Myasthenic Syndromes, Congenital/complications ; Treatment Outcome ; United Kingdom ; Young Adult
Language English
Publishing date 2021-06-13
Publishing country Netherlands
Document type Journal Article
ISSN 2214-3602
ISSN (online) 2214-3602
DOI 10.3233/JND-210699
Database MEDical Literature Analysis and Retrieval System OnLINE

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