Article: Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders.
2021 Volume 9, Page(s) 20503121211002996
Abstract: ... leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism ... Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe ... behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding ...
| Abstract | Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding, cytokine storm, and direct viral endothelial damage. SARS-CoV-2 has also been recently found to bind to CLEC4M receptor, a receptor that participates in the clearance of von Willebrand Factor and Factor VIII. The competitive binding of SARS-CoV-2 to CLEC4M could lead to decreased clearance, and therefore a promotion of a pro-coagulative state; however, an experimental study needs to be done to prove such an association. |
|---|---|
| Language | English |
| Publishing date | 2021-03-21 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2735399-0 |
| ISSN | 2050-3121 |
| ISSN | 2050-3121 |
| DOI | 10.1177/20503121211002996 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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