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  1. Article: Coronavirus disease 2019: Implications of severe acute respiratory syndrome coronavirus 2 in acute kidney injury.

    Alenazi, Abeer Ageel / AlDkhil, Lujain Mohammad Dkhil

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2021  Volume 31, Issue 6, Page(s) 1456–1457

    MeSH term(s) Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Acute Kidney Injury/virology ; COVID-19/complications ; China ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-10
    Publishing country Saudi Arabia
    Document type Letter
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    DOI 10.4103/1319-2442.308374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4735: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.

    Gilbert, Richard E / Caldwell, Lauren / Misra, Paraish S / Chan, Kin / Burns, Kevin D / Wrana, Jeffrey L / Yuen, Darren A

    Canadian journal of diabetes

    2020  Volume 45, Issue 2, Page(s) 162–166.e1

    Abstract: ... disease 19 (COVID-19) infection. Beyond the lungs, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS ... the kidney, potentially contributing to acute kidney injury in those with severe disease. We hypothesized ... of kidney infection with SARS-CoV-2 in the setting of COVID-19 disease. Further studies are needed ...

    Abstract Objectives: Diabetes is associated with adverse outcomes, including death, after coronavirus disease 19 (COVID-19) infection. Beyond the lungs, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of the COVID-19 pandemic, can infect a range of other tissues, including the kidney, potentially contributing to acute kidney injury in those with severe disease. We hypothesized that the renal abundance of angiotensin-converting enzyme (ACE) 2, the cell surface receptor for SARS-CoV-2, may be modulated by diabetes and agents that block the renin-angiotensin-aldosterone system (RAAS).
    Methods: The expression of ACE 2 was examined in 49 archival kidney biopsies from patients with diabetic kidney disease and from 12 healthy, potential living allograft donors using next-generation sequencing technology (RNA Seq).
    Results: Mean ACE 2 messenger RNA was increased approximately 2-fold in diabetes when compared with healthy control subjects (mean ± SD, 13.2±7.9 vs 7.7±3.6 reads per million reads, respectively; p=0.001). No difference in transcript abundance was noted between recipients and nonrecipients of agents that block the RAAS (12.2±6.7 vs 16.2±10.7 reads per million reads, respectively; p=0.25).
    Conclusions: Increased ACE 2 messenger RNA in the diabetic kidney may increase the risk and/or severity of kidney infection with SARS-CoV-2 in the setting of COVID-19 disease. Further studies are needed to ascertain whether this diabetes-related overexpression is generalizable to other tissues, most notably the lungs.
    MeSH term(s) Acute Kidney Injury/virology ; Adult ; Aged ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/complications ; COVID-19/virology ; Case-Control Studies ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/metabolism ; Female ; Host-Pathogen Interactions ; Humans ; Male ; Middle Aged ; SARS-CoV-2/metabolism
    Chemical Substances ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-18
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2020.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019

    Gilbert, Richard E / Caldwell, Lauren / Misra, Paraish S / Chan, Kin / Burns, Kevin D / Wrana, Jeffrey L / Yuen, Darren A

    Abstract: ... disease 19 (COVID-19) infection. Beyond the lungs, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS ... the kidney, potentially contributing to acute kidney injury in those with severe disease. We hypothesized ... of kidney infection with SARS-CoV-2 in the setting of COVID-19 disease. Further studies are needed ...

    Abstract OBJECTIVES: Diabetes is associated with adverse outcomes, including death, after coronavirus disease 19 (COVID-19) infection. Beyond the lungs, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of the COVID-19 pandemic, can infect a range of other tissues, including the kidney, potentially contributing to acute kidney injury in those with severe disease. We hypothesized that the renal abundance of angiotensin-converting enzyme (ACE) 2, the cell surface receptor for SARS-CoV-2, may be modulated by diabetes and agents that block the renin-angiotensin-aldosterone system (RAAS). METHODS: The expression of ACE 2 was examined in 49 archival kidney biopsies from patients with diabetic kidney disease and from 12 healthy, potential living allograft donors using next-generation sequencing technology (RNA Seq). RESULTS: Mean ACE 2 messenger RNA was increased approximately 2-fold in diabetes when compared with healthy control subjects (mean ± SD, 13.2±7.9 vs 7.7±3.6 reads per million reads, respectively; p=0.001). No difference in transcript abundance was noted between recipients and nonrecipients of agents that block the RAAS (12.2±6.7 vs 16.2±10.7 reads per million reads, respectively; p=0.25). CONCLUSIONS: Increased ACE 2 messenger RNA in the diabetic kidney may increase the risk and/or severity of kidney infection with SARS-CoV-2 in the setting of COVID-19 disease. Further studies are needed to ascertain whether this diabetes-related overexpression is generalizable to other tissues, most notably the lungs.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #764996
    Database COVID19

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  4. Article ; Online: Coronavirus disease 2019

    Abeer Ageel Alenazi / Lujain Mohammad Dkhil AlDkhil

    Saudi Journal of Kidney Diseases and Transplantation, Vol 31, Iss 6, Pp 1456-

    Implications of severe acute respiratory syndrome coronavirus 2 in acute kidney injury

    2020  Volume 1457

    Keywords Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes.

    Bärreiter, Valentin A / Meister, Toni L

    Current opinion in microbiology

    2024  Volume 79, Page(s) 102475

    Abstract: ... severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients ... can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 ... exhibited a variety of symptoms such as acute proximal tubular injury, ischemic collapse, and severe acute ...

    Abstract In recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibited a variety of symptoms such as acute proximal tubular injury, ischemic collapse, and severe acute tubular necrosis resulting in irreversible kidney failure. This review summarizes the current knowledge on how it is believed that SARS-CoV-2 influences the renal environment and induces kidney disease, as well as current therapy approaches.
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2024.102475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

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  6. Article ; Online: The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.

    Ning, Qin / Wu, Di / Wang, Xiaojing / Xi, Dong / Chen, Tao / Chen, Guang / Wang, Hongwu / Lu, Huiling / Wang, Ming / Zhu, Lin / Hu, Junjian / Liu, Tingting / Ma, Ke / Han, Meifang / Luo, Xiaoping

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 57

    Abstract: ... by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 ... primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome ... The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused ...

    Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/immunology ; Acute Kidney Injury/virology ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; Clinical Trials as Topic ; Cytokine Release Syndrome/complications ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Disseminated Intravascular Coagulation/complications ; Disseminated Intravascular Coagulation/drug therapy ; Disseminated Intravascular Coagulation/immunology ; Disseminated Intravascular Coagulation/virology ; Endothelial Cells/drug effects ; Endothelial Cells/immunology ; Endothelial Cells/virology ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/therapeutic use ; Lymphopenia/complications ; Lymphopenia/drug therapy ; Lymphopenia/immunology ; Lymphopenia/virology ; Myocarditis/complications ; Myocarditis/drug therapy ; Myocarditis/immunology ; Myocarditis/virology ; Pulmonary Embolism/complications ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/immunology ; Pulmonary Embolism/virology ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/growth & development ; SARS-CoV-2/pathogenicity
    Chemical Substances Anticoagulants ; Antiviral Agents ; Immunologic Factors
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-00907-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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