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  1. Article ; Online: COVID-19 and Lipid Disorders.

    Julius, Ulrich / Schatz, Ulrike / Tselmin, Sergey / Morawietz, Henning

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 8, Page(s) 514–521

    Abstract: ... In contrast, higher HDL-cholesterol levels seem to be protective. During COVID-19 disease, LDL-cholesterol and ... formation. The same is suspected for the SARS-COV-2 infection itself. COVID-19 patients are at increased ... the COVID-19 disease, though the impact of lipid-lowering drugs or the extracorporeal therapy on prognosis ...

    Abstract An elevated cholesterol concentration has been suspected to increase the susceptibility for SARS-COV-2 infection. Cholesterol plays a central role in the mechanisms of the SARS-COV-2 infection. In contrast, higher HDL-cholesterol levels seem to be protective. During COVID-19 disease, LDL-cholesterol and HDL-cholesterol appear to be decreased. On the other hand, triglycerides (also in different lipoprotein fractions) were elevated. Lipoprotein(a) may increase during this disease and is most probably responsible for thromboembolic events. This lipoprotein can induce a progression of atherosclerotic lesion formation. The same is suspected for the SARS-COV-2 infection itself. COVID-19 patients are at increased risk of incident cardiovascular diseases, including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, and thromboembolic disorders. An ongoing lipid-lowering therapy, including lipoprotein apheresis, is recommended to be continued during the COVID-19 disease, though the impact of lipid-lowering drugs or the extracorporeal therapy on prognosis should be studied in further investigations.
    MeSH term(s) COVID-19/complications ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Lipoproteins ; Risk Factors ; SARS-CoV-2 ; Triglycerides
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-07-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1860-2610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiac MRI in Suspected Acute Myocarditis After COVID-19 mRNA Vaccination.

    Kravchenko, Dmitrij / Isaak, Alexander / Mesropyan, Narine / Endler, Christoph / Bischoff, Leon / Vollbrecht, Thomas / Pieper, Claus Christian / Sedaghat, Alexander / Kuetting, Daniel / Hart, Christopher / Feisst, Andreas / Attenberger, Ulrike / Luetkens, Julian Alexander

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2022  Volume 194, Issue 9, Page(s) 1003–1011

    Abstract: ... myocarditis following mRNA COVID-19 vaccination.: Materials and methods: Patients clinically suspected ... of acute myocarditis after COVID-19 vaccination were retrospectively analyzed and compared against ... Myocarditis After COVID-19 mRNA Vaccination. Fortschr Röntgenstr 2022; 194: 1003 - 1011. ...

    Title translation Befunde der kardialen MRT bei Patienten mit Verdacht auf eine akute Myokarditis nach COVID-19-mRNA-Impfung.
    Abstract Purpose: To evaluate cardiac MRI characteristics in patients with suspected hypersensitivity myocarditis following mRNA COVID-19 vaccination.
    Materials and methods: Patients clinically suspected of acute myocarditis after COVID-19 vaccination were retrospectively analyzed and compared against a healthy control group. Cardiac MRI protocol included parameters such as T1 and T2 relaxation times, extracellular volume (ECV), T2 signal intensity ratio, and late gadolinium enhancement (LGE). Lymph node size was assessed in the patient group on the injection side. Student t-test, analyses of variance (ANOVA) with Tukey post-hoc test, and χ
    Results: 20 patients with clinically suspected post-vaccine myocarditis (28 ± 12 years; 12 men) and 40 controls (31 ± 11 years; 25 men) were evaluated. According to the 2018 Lake Louise criteria (LLC), patients with clinically suspected myocarditis were further subdivided into an LLC-positive group (n = 9) and an LLC-negative group (n = 11). The mean time of symptom onset after vaccination was 1.1 ± 1.2 days (LLC-positive) and 6.5 ± 9.2 days (LLC-negative). Group differences in inflammatory variables between myocarditis patients and control subjects were more pronounced in the LLC-positive group (e. g., T1 relaxation time: 1041 ± 61 ms [LLC positive] vs. 1008 ± 79 ms [LLC-negative] vs. 970 ± 25 ms [control]; p <.001; or T2 signal intensity ratio 2.0 ± 0.3 vs. 1.6 ± 0.3 [LLC-negative] and vs. 1.6 ± 0.3 [control], p = .012). LLC-positive patients were significantly faster in receiving an MRI after initial symptom onset (8.8 ± 6.1 days vs. 52.7 ± 33.4 days; p = .001) and had higher troponin T levels (3938 ± 5850 ng/l vs. 9 ± 11 ng/l; p <.001). LGE lesions were predominantly located at the subepicardium of the lateral wall. Axillary lymphadenopathy was more frequent in the LLC-positive group compared to the LLC-negative group (8/9 [89 %] vs. 0/11 [0 %], p < 0.001).
    Conclusion: Vaccine-induced myocarditis should be considered in patients with acute symptom onset after mRNA vaccination, especially if elevated serum troponin T is observed. Imaging findings of vaccine-induced myocarditis are similar to virus-induced myocarditis, allowing for the use of the Lake Louise Criteria for diagnostic purposes.
    Key points: · Vaccine-induced hypersensitivity myocarditis can be confirmed with cardiac MRI. · Especially patients with sudden onset of symptoms and elevated serum troponin T had positive cardiac MRI findings. · Cardiac MRI characteristics of vaccine-induced myocarditis are similar to those in virus-induced myocarditis.
    Citation format: · Kravchenko D, Isaak A, Mesropyan N et al. Cardiac MRI in Suspected Acute Myocarditis After COVID-19 mRNA Vaccination. Fortschr Röntgenstr 2022; 194: 1003 - 1011.
    MeSH term(s) Adolescent ; Adult ; COVID-19 ; COVID-19 Vaccines ; Contrast Media ; Female ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Male ; Myocarditis ; Predictive Value of Tests ; RNA, Messenger ; Retrospective Studies ; Troponin T ; Vaccination ; Young Adult
    Chemical Substances COVID-19 Vaccines ; Contrast Media ; RNA, Messenger ; Troponin T ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2022-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-1752-0951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The sequel to COVID-19

    Bhandari, Sudhir / Shaktawat, Ajit Singh / Patel, Bhoopendra / Dube, Amitabh / Kakkar, Shivankan / Tak, Amit / Gupta, Jitendra / Rankawat, Govind

    Journal of Ideas in Health; Vol 3 No Special; 205-212 ; 2645-9248

    the antithesis to life

    2020  Volume 1, Issue : COVID-19 Related Special Issue- September 2020

    Abstract: ... A, Subramanyan A, et al. Psychological impact of COVID19 lockdown: An online survey from India. Indian J ... The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or ... their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath ...

    Abstract The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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    Keywords covid19
    Subject code 360
    Language English
    Publishing date 2020-10-01
    Publisher Saad Ahmed Ali Al-EZZI
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.

    Săndulescu, Maria Sidonia / Văduva, Constantin Cristian / Siminel, Mirela Anişoara / Dijmărescu, Anda Lorena / Vrabie, Sidonia Cătălina / Camen, Ioana Victoria / Tache, Daniela Elise / Neamţu, Simona Daniela / Nagy, Rodica Daniela / Carp-Velişcu, Andreea / Manolea, Maria Magdalena

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2023  Volume 63, Issue 3, Page(s) 503–510

    Abstract: ... in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage ... The appearance of coronavirus disease 2019 (COVID-19) caused ... activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical ...

    Abstract The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical, social, economic, and political instability. The aim of this study was to make an analysis of the scientific data obtained by so far to highlight the impact that COVID-19 has had on fertility and assisted reproductive technology (ART). Infection with SARS-CoV-2 alters the normal immune response by local and systemic damage to tissues and organs. After the virus enters the body, the first lesions are produced in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage, hepatocellular lesions, neurological diseases, myocardial dysfunction and arrhythmia, gastrointestinal diseases but also genital impairment. The possible impairment of the male reproductive system is because angiotensin-converting enzyme 2 (ACE2) receptors are in an increased number in the testes, seminiferous duct cells, spermatogonia, Leydig cells and Sertoli cells. Many published studies to date have pointed out that COVID-19 could also affect female fertility and disrupt the functions of the female reproductive system. The theory that this virus can also be transmitted sexually and can cause infertility or testicular damage is supported by the fact that the virus can be isolated in the semen of COVID-19 patients but only during the disease. Choosing the best method of treating infertility during the COVID-19 pandemic is multifactorial, but the risk of infection and compliance with specific ART hygiene protocols must always be considered. Currently, there is no scientific basis regarding the fact that the COVID-19 vaccination would influence fertility.
    MeSH term(s) Humans ; Male ; Female ; COVID-19/complications ; SARS-CoV-2 ; Pandemics ; COVID-19 Vaccines ; Peptidyl-Dipeptidase A ; Fertility ; Infertility
    Chemical Substances COVID-19 Vaccines ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2023-01-19
    Publishing country Romania
    Document type Systematic Review ; Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.63.3.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cardiac MRI in Suspected Acute Myocarditis After COVID-19 mRNA Vaccination

    Kravchenko, Dmitrij / Isaak, Alexander / Mesropyan, Narine / Endler, Christoph / Bischoff, Leon / Vollbrecht, Thomas / Pieper, Claus Christian / Sedaghat, Alexander / Kuetting, Daniel / Hart, Christopher / Feisst, Andreas / Attenberger, Ulrike / Luetkens, Julian Alexander

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2022  Volume 194, Issue 09, Page(s) 1003–1011

    Abstract: ... myocarditis following mRNA COVID-19 vaccination.: Materials and Methods: Patients clinically suspected ... of acute myocarditis after COVID-19 vaccination were retrospectively analyzed and compared against ... in Suspected Acute Myocarditis After COVID-19 mRNA Vaccination. Fortschr Röntgenstr 2022; 194: 1003 – 1011 ...

    Abstract Purpose: To evaluate cardiac MRI characteristics in patients with suspected hypersensitivity myocarditis following mRNA COVID-19 vaccination.
    Materials and Methods: Patients clinically suspected of acute myocarditis after COVID-19 vaccination were retrospectively analyzed and compared against a healthy control group. Cardiac MRI protocol included parameters such as T1 and T2 relaxation times, extracellular volume (ECV), T2 signal intensity ratio, and late gadolinium enhancement (LGE). Lymph node size was assessed in the patient group on the injection side. Student t-test, analyses of variance (ANOVA) with Tukey post-hoc test, and χ 2 test were used for statistical analysis.
    Results: 20 patients with clinically suspected post-vaccine myocarditis (28 ± 12 years; 12 men) and 40 controls (31 ± 11 years; 25 men) were evaluated. According to the 2018 Lake Louise criteria (LLC), patients with clinically suspected myocarditis were further subdivided into an LLC-positive group (n = 9) and an LLC-negative group (n = 11). The mean time of symptom onset after vaccination was 1.1 ± 1.2 days (LLC-positive) and 6.5 ± 9.2 days (LLC-negative). Group differences in inflammatory variables between myocarditis patients and control subjects were more pronounced in the LLC-positive group (e. g., T1 relaxation time: 1041 ± 61 ms [LLC positive] vs. 1008 ± 79 ms [LLC-negative] vs. 970 ± 25 ms [control]; p <.001; or T2 signal intensity ratio 2.0 ± 0.3 vs. 1.6 ± 0.3 [LLC-negative] and vs. 1.6 ± 0.3 [control], p = .012). LLC-positive patients were significantly faster in receiving an MRI after initial symptom onset (8.8 ± 6.1 days vs. 52.7 ± 33.4 days; p = .001) and had higher troponin T levels (3938 ± 5850 ng/l vs. 9 ± 11 ng/l; p <.001). LGE lesions were predominantly located at the subepicardium of the lateral wall. Axillary lymphadenopathy was more frequent in the LLC-positive group compared to the LLC-negative group (8/9 [89 %] vs. 0/11 [0 %], p < 0.001).
    Conclusion: Vaccine-induced myocarditis should be considered in patients with acute symptom onset after mRNA vaccination, especially if elevated serum troponin T is observed. Imaging findings of vaccine-induced myocarditis are similar to virus-induced myocarditis, allowing for the use of the Lake Louise Criteria for diagnostic purposes.
    Key Points: Vaccine-induced hypersensitivity myocarditis can be confirmed with cardiac MRI Especially patients with sudden onset of symptoms and elevated serum troponin T had positive cardiac MRI findings Cardiac MRI characteristics of vaccine-induced myocarditis are similar to those in virus-induced myocarditis
    Citation Format: Kravchenko D, Isaak A, Mesropyan N et al. Cardiac MRI in Suspected Acute Myocarditis After COVID-19 mRNA Vaccination. Fortschr Röntgenstr 2022; 194: 1003 – 1011
    Keywords vaccine ; myocarditis ; cardiac MRI ; COVID-19
    Language English
    Publishing date 2022-03-10
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/a-1752-0951
    Database Thieme publisher's database

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