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  1. Article: Prevalence and mortality of lung comorbidities among patients with COVID-19: A systematic review and meta-analysis.

    Alkhathami, Mohammed G / Advani, Shailesh M / Abalkhail, Adil A / Alkhathami, Fahad M / Alshehri, Mohammed K / Albeashy, Ebtisam E / Alsalamah, Jihad A

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue Supplement, Page(s) S31–S40

    Abstract: ... to assess other lung comorbidities and associated mortality among patients diagnosed with COVID-19. ... that reported prevalence of chronic lung conditions among COVID-19 patients. Among those, 26 were from China and ... among patients with COVID-19. Asthma, followed by COPD and lung cancer, was the most common lung comorbidity ...

    Abstract COVID-19 infections are seen across all age groups, but they have shown to have a predisposition for the elderly and those with underlying comorbidities. Patients with severe COVID-19 infections and comorbidities are more prone to respiratory distress syndrome, mechanical ventilator use, and ultimately succumb to these complications. Little evidence exists of the prevalence of underlying lung comorbidities among COVID-19 patients and associated mortality. We performed a systematic review of the literature including PubMed (Medline), Embase (Ovid), Google Scholar, and Cochrane Library. The last date for our search was April 29, 2020. We included all original research articles on COVID-19 and calculated prevalence of chronic lung disease patients among COVID-19 patients using random effects model. Further, we assessed for mortality rates among COVID-19 patients associated with these lung comorbidities. The authors identified 29 articles that reported prevalence of chronic lung conditions among COVID-19 patients. Among those, 26 were from China and 3 from the United States. The pooled prevalence of lung comorbidities including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer was 3% (95% confidence interval [CI] = 0%-14%), 2.2% (95% CI = 0.02%-0.03%), and 2.1% (95% CI = 0.00%-0.21%), respectively. Mortality rates associated with these comorbidities was 30% (41/137) for COPD and 19% (7/37) for lung cancer respectively. No mortality rates were reported for patients with asthma. This study offers latest evidence of prevalence of chronic lung conditions among patients with COVID-19. Asthma, followed by COPD and lung cancer, was the most common lung comorbidity associated with COVID-19, while the higher mortality rate was found in COPD. Future studies are needed to assess other lung comorbidities and associated mortality among patients diagnosed with COVID-19.
    Language English
    Publishing date 2021-03-08
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_497_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence and mortality of Lung Comorbidities Among Patients with COVID-19: A systematic review and meta-analysis

    Alkhathami, M. G. / Advani, S. / Al Shehri, M. K. / Abalkhail, A. / Alkhathami, F. / Al Salamah, J. A. / Albeashy, E.

    Abstract: ... evidence exists of the prevalence of underlying lung comorbidities among COVID-19 patients and associated ... are needed to assess other lung comorbidities and associated mortality among patients diagnosed ... among COVID-19 patients associated with these lung comorbidities. We calculated pooled prevalence ...

    Abstract Abstract Background The World Health Organization declared COVID-19 associated infections as a global health public emergency that has led to more than 3,50,000 deaths worldwide. COVID-19 infections are seen across all age groups but they have shown to have a predisposition for the elderly and those with underlying comorbidities. Specifically, these include cardiovascular diseases, diabetes and underlying lung conditions. Further, patients with severe COVID-19 infections and comorbidities are more prone to respiratory distress syndrome (ARDS), mechanical ventilator use and ultimately succumb to these complications. Little evidence exists of the prevalence of underlying lung comorbidities among COVID-19 patients and associated mortality. Methods We performed a systematic review of the literature including PubMed (Medline), Embase (Ovid), Google Scholar and Cochrane Library. The last date for our search was 29th April 2020. We included all original research articles on COVID-19 and calculated prevalence of chronic lung disease patients among COVID-19 patients using random effects model. Further we assessed for mortality rates among COVID-19 patients associated with these lung comorbidities. We calculated pooled prevalence of these conditions among COVID-19 patients using random effects model. Results The authors identified 29 articles that reported the prevalence of chronic lung conditions among COVID-19 patients. Among those, 26 were from China and 3 from the United States. The pooled prevalence of lung comorbidities including Asthma, COPD, and lung cancer was 3% (95% CI=0-14%), 2.2% (95% CI=0.02-0.03%) and 2.1% (95% CI=0.00-0.21%) respectively. Mortality rates associated with these comorbidities was 30% (41/137) for COPD and 19% (7/37) for lung cancer respectively. No mortality rates were reported for patients with asthma. Conclusion This study provides preliminary evidence of the prevalence of chronic lung conditions among patients with COVID-19. Future studies are needed to assess other lung comorbidities and associated mortality among patients diagnosed with COVID-19.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.06.01.20119271
    Database COVID19

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  3. Article ; Online: Prevalence of underlying diseases in died cases of COVID-19

    Fatemeh Javanmardi / Abdolkhalegh Keshavarzi / Ali Akbari / Amir Emami / Neda Pirbonyeh

    PLoS ONE, Vol 15, Iss 10, p e

    A systematic review and meta-analysis.

    2020  Volume 0241265

    Abstract: ... mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes should be ... morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating ... underlying disease in died cases of COVID-19 were included in the analysis. Results After screening and ...

    Abstract Introduction Underlying disease have a critical role in vulnerability of populations for a greater morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating the prevalence of underlying disease in died people with COVID-19. Methods The current study have been conducted according to PRISMA guideline. International database including PubMed, Scopus, Web of Science, Cochrane and google scholar were searched for relevant studies up to 1 June. All relevant articles that reported underlying disease in died cases of COVID-19 were included in the analysis. Results After screening and excluding duplicated and irrelevant studies, 32 articles included in the analysis. The most prevalent comorbidities were hypertension, diabetes, cardiovascular disease, liver disease, lung disease, malignancy, cerebrovascular disease, COPD and asthma. Among all reported underlying disease, highest and lowest prevalence was related to hypertension and asthma which were estimated 46% (37% - 55%) and 3% (2%- 6%), respectively. Conclusion In summary, underlying disease have a critical role in poor outcomes, severity of disease and high mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes should be carefully monitored and be aware of health protocols.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Prevalence of comorbidity in Chinese patients with COVID-19: systematic review and meta-analysis of risk factors.

    Yin, Tingxuan / Li, Yuanjun / Ying, Ying / Luo, Zhijun

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 200

    Abstract: ... the prevalence of comorbidities in severe and non-severe COVID-19 patients. A total of 41 studies comprising 12 ... a systematic review with a meta-analysis on the relationship of COVID-19 severity with 8 different underlying ... mortality among COVID-19 patients. To assess the role of comorbidity in COVID-19 progression, we performed ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is an infectious disease characterized by cough, fever, and fatigue and 20% of cases will develop into severe conditions resulting from acute lung injury with the manifestation of the acute respiratory distress syndrome (ARDS) that accounts for more than 50% of mortality. Currently, it has been reported that some comorbidities are linked with an increased rate of severity and mortality among COVID-19 patients. To assess the role of comorbidity in COVID-19 progression, we performed a systematic review with a meta-analysis on the relationship of COVID-19 severity with 8 different underlying diseases.
    Methods: PubMed, Web of Science, and CNKI were searched for articles investigating the prevalence of comorbidities in severe and non-severe COVID-19 patients. A total of 41 studies comprising 12,526 patients were included.
    Results: Prevalence of some commodities was lower than that in general population such as hypertension (19% vs 23.2%), diabetes (9% vs 10.9%), chronic kidney disease (CKD) (2% vs 9.5%), chronic liver diseases (CLD) (3% vs 24.8%) and chronic obstructive pulmonary disease (COPD) (3% vs 8.6%), while some others including cancer (1% vs 0.6%), cardiovascular disease (6% vs 1.8%) and cerebrovascular disease (2% vs 0.9%) exhibited greater percentage in COVID-19. Cerebrovascular disease (OR = 3.70, 95%CI 2.51-5.45) was found to be the strongest risk factor in disease exacerbation, followed by CKD (OR = 3.60, 95%CI 2.18-5.94), COPD (OR = 3.14, 95% CI 2.35-4.19), cardiovascular disease (OR = 2.76, 95% CI 2.18-3.49), malignancy (OR = 2.63, 95% CI 1.75-3.95), diabetes (OR = 2.49, 95% CI 2.10-2.96) and hypertension (OR = 2.13, 95% CI 1.81-2.51). We found no correlation between CLD and increased disease severity (OR = 1.32, 95% CI 0.96-1.82).
    Conclusion: The impact of all eight underlying diseases on COVID-19 deterioration seemed to be higher in patients outside Hubei. Based on different comorbidities, COVID-19 patients tend to be at risk of developing poor outcomes to a varying degree. Thus, tailored infection prevention and monitoring and treatment strategies targeting these high-risk subgroups might improve prognosis during the COVID-19 pandemic.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Cardiovascular Diseases/epidemiology ; Cerebrovascular Disorders/epidemiology ; China/epidemiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Humans ; Neoplasms/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05915-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis.

    Javanmardi, Fatemeh / Keshavarzi, Abdolkhalegh / Akbari, Ali / Emami, Amir / Pirbonyeh, Neda

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0241265

    Abstract: ... outcomes, severity of disease and high mortality rate of COVID-19 cases. Patients with hypertension ... for a greater morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating ... that reported underlying disease in died cases of COVID-19 were included in the analysis.: Results: After ...

    Abstract Introduction: Underlying disease have a critical role in vulnerability of populations for a greater morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating the prevalence of underlying disease in died people with COVID-19.
    Methods: The current study have been conducted according to PRISMA guideline. International database including PubMed, Scopus, Web of Science, Cochrane and google scholar were searched for relevant studies up to 1 June. All relevant articles that reported underlying disease in died cases of COVID-19 were included in the analysis.
    Results: After screening and excluding duplicated and irrelevant studies, 32 articles included in the analysis. The most prevalent comorbidities were hypertension, diabetes, cardiovascular disease, liver disease, lung disease, malignancy, cerebrovascular disease, COPD and asthma. Among all reported underlying disease, highest and lowest prevalence was related to hypertension and asthma which were estimated 46% (37% - 55%) and 3% (2%- 6%), respectively.
    Conclusion: In summary, underlying disease have a critical role in poor outcomes, severity of disease and high mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes should be carefully monitored and be aware of health protocols.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Diabetes Mellitus/epidemiology ; Humans ; Hypertension/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Prevalence ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0241265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis

    Javanmardi, Fatemeh / Keshavarzi, Abdolkhalegh / Akbari, Ali / Emami, Amir / Pirbonyeh, Neda

    PLoS One

    Abstract: ... high mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes ... morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating ... underlying disease in died cases of COVID-19 were included in the analysis. RESULTS: After screening and ...

    Abstract INTRODUCTION: Underlying disease have a critical role in vulnerability of populations for a greater morbidity and mortality when they suffer from COVID-19. The aim of current study is evaluating the prevalence of underlying disease in died people with COVID-19. METHODS: The current study have been conducted according to PRISMA guideline. International database including PubMed, Scopus, Web of Science, Cochrane and google scholar were searched for relevant studies up to 1 June. All relevant articles that reported underlying disease in died cases of COVID-19 were included in the analysis. RESULTS: After screening and excluding duplicated and irrelevant studies, 32 articles included in the analysis. The most prevalent comorbidities were hypertension, diabetes, cardiovascular disease, liver disease, lung disease, malignancy, cerebrovascular disease, COPD and asthma. Among all reported underlying disease, highest and lowest prevalence was related to hypertension and asthma which were estimated 46% (37% - 55%) and 3% (2%- 6%), respectively. CONCLUSION: In summary, underlying disease have a critical role in poor outcomes, severity of disease and high mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes should be carefully monitored and be aware of health protocols.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #890196
    Database COVID19

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