Article ; Online: How Could This Happen? : Narrowing Down the Contagion of COVID-19 and Preventing Acute Respiratory Distress Syndrome (ARDS).
2020 Volume 68, Issue 4, Page(s) 441–452
Abstract: ... distress syndrome (ARDS). The available knowledge on the viral genomics, molecular biology and ... the etiology and epidemiology of the new coronavirus 2019-nCoV and the risks for developing Acute respiratory ... ARDS, fatal cardiac and renal failures, associated with a number of important comorbidity factors ...
| Abstract | In this rapid commentary, a mini-review is given of the present state-of-knowledge regarding the etiology and epidemiology of the new coronavirus 2019-nCoV and the risks for developing Acute respiratory distress syndrome (ARDS). The available knowledge on the viral genomics, molecular biology and pathogenicity of viruses of the Coronaviridae family and other Nidovirales, forms a helpful template for understanding the present pandemic outbreak. However, important questions remain unanswered about the underlying mechanism causing the very high case fatality ratios (CFR) and mechanisms regarding severe reactions like ARDS, fatal cardiac and renal failures, associated with a number of important comorbidity factors. Immunological reactions to lung alveoles in particular (involving lung macrophages and alveolar epithelial cell damage) in late phase ARDS in SARS-like CoV diseases, so far may not have received enough attention. Finally a shortlist of questions for high priority further research is suggested. |
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| MeSH term(s) | Acute Kidney Injury/complications ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Disease Outbreaks ; Epithelial Cells/metabolism ; Heart Failure/complications ; Humans ; Lung/metabolism ; Lung/virology ; Macrophages/metabolism ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/prevention & control ; Respiratory Distress Syndrome/virology ; Risk Factors ; SARS-CoV-2 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-25 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ZDB-ID | 63-2 |
| ISSN | 1572-8358 ; 0001-5342 |
| ISSN (online) | 1572-8358 |
| ISSN | 0001-5342 |
| DOI | 10.1007/s10441-020-09382-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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