Article ; Online: TIMP-1 Promotes the Immune Response in Influenza-Induced Acute Lung Injury.
2018 Volume 196, Issue 6, Page(s) 737–743
Abstract: ... in the host response to influenza-induced lung injury.: Methods: Wild-type (WT) and Timp1-deficient (Timp1 ... suggest that Timp1 promotes the immune response in the lungs after influenza infection facilitating ... for influenza related complications. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a secreted protein ...
| Abstract | Introduction: Influenza infects millions of people each year causing respiratory distress and death in severe cases. On average, 200,000 people annually are hospitalized in the United States for influenza related complications. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a secreted protein that inhibits MMPs, has been found to be involved in lung inflammation. Here, we evaluated the role of TIMP-1 in the host response to influenza-induced lung injury. Methods: Wild-type (WT) and Timp1-deficient (Timp1 Results: WT mice experienced significantly more weight loss compared to Timp1 Conclusion: The data suggest that Timp1 promotes the immune response in the lungs after influenza infection facilitating an injurious phenotype as a result of influenza infection. |
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| MeSH term(s) | Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Acute Lung Injury/pathology ; Acute Lung Injury/virology ; Animals ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Disease Models, Animal ; Erythrocyte Count ; Erythrocytes ; Hemorrhage/genetics ; Hemorrhage/virology ; Influenza A Virus, H1N1 Subtype ; Leukocyte Count ; Macrophages ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils ; Orthomyxoviridae Infections/complications ; Orthomyxoviridae Infections/virology ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Viral Load/genetics ; Weight Loss/genetics | |||||
| Chemical Substances | Timp1 protein, mouse ; Tissue Inhibitor of Metalloproteinase-1 | |||||
| Language | English | |||||
| Publishing date | 2018-08-30 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 6165-7 | |||||
| ISSN | 1432-1750 ; 0341-2040 | |||||
| ISSN (online) | 1432-1750 | |||||
| ISSN | 0341-2040 | |||||
| DOI | 10.1007/s00408-018-0154-2 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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