Article ; Online: Gene expressions of TRP channels in glioblastoma multiforme and relation with survival.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
2015 Volume 36, Issue 12, Page(s) 9209–9213
Abstract: ... with glioblastoma multiforme and to evaluate the relationship between TRP gene expressions and survival ... demonstrate for the first time that TRP channels contribute to the progression and survival ... relationship between the overexpression of TRP genes and the survival of the patients. These results ...
| Abstract | Glioblastoma multiforme (GBM) is one of the most lethal forms of cancer in humans, with a median survival of 10 to 12 months. Glioblastoma is highly malignant since the cells are supported by a great number of blood vessels. Although new treatments have been developed by increasing knowledge of molecular nature of the disease, surgical operation remains the standard of care. The TRP (transient receptor potential) superfamily consists of cation-selective channels that have roles in sensory physiology such as thermo- and osmosensation and in several complex diseases such as cancer, cardiovascular, and neuronal diseases. The aim of this study was to investigate the expression levels of TRP channel genes in patients with glioblastoma multiforme and to evaluate the relationship between TRP gene expressions and survival of the patients. Thirty-three patients diagnosed with glioblastoma were enrolled to the study. The expression levels of 21 TRP genes were quantified by using qRT-PCR with dynamic array 48 × 48 chip (BioMark HD System, Fluidigm, South San Francisco, CA, USA). TRPC1, TRPC6, TRPM2, TRPM3, TRPM7, TRPM8, TRPV1, and TRPV2 were found significantly higher in glioblastoma patients. Moreover, there was a significant relationship between the overexpression of TRP genes and the survival of the patients. These results demonstrate for the first time that TRP channels contribute to the progression and survival of the glioblastoma patients. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Aged ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Male ; Middle Aged ; Multigene Family/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Survival Analysis ; Transient Receptor Potential Channels/biosynthesis ; Transient Receptor Potential Channels/genetics | |||||
| Chemical Substances | RNA, Messenger ; Transient Receptor Potential Channels | |||||
| Language | English | |||||
| Publishing date | 2015-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 605825-5 | |||||
| ISSN | 1423-0380 ; 0289-5447 ; 1010-4283 | |||||
| ISSN (online) | 1423-0380 | |||||
| ISSN | 0289-5447 ; 1010-4283 | |||||
| DOI | 10.1007/s13277-015-3577-x | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1598: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.