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  1. Article ; Online: Anti-NMDA receptor encephalitis secondary to SARS-CoV-2 infection

    Alvarez Bravo, G. / Ramió i Torrentà, L.

    Neurología (English Edition) ; ISSN 2173-5808

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.nrleng.2020.07.011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Possible temporal relationship between SARS-CoV-2 infection and anti-NMDA receptor encephalitis: a meta-analysis.

    Vasilevska, Veronika / Guest, Paul C / Szardenings, Michael / Benros, Michael E / Steiner, Johann

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 139

    Abstract: ... of NMDA receptor encephalitis associated with SARS-CoV-2 infection or vaccination by a systematic ... causal relationship exists between SARS-CoV-2 infection or vaccination and manifestation of NMDA receptor ... The global impact of SARS-CoV-2 infection has raised concerns about secondary diseases beyond acute ...

    Abstract The global impact of SARS-CoV-2 infection has raised concerns about secondary diseases beyond acute illness. This review explores the significance and potential underlying mechanisms of how SARS-CoV-2 infection might elicit an immune response targeting N-methyl-D-aspartate (NMDA) receptors, and its implications for autoimmune-driven neuropsychiatric manifestations. We identified 19 published case reports of NMDA receptor encephalitis associated with SARS-CoV-2 infection or vaccination by a systematic literature search. The significance of these reports was limited since it is not clear if a coincidental or causal relationship exists between SARS-CoV-2 infection or vaccination and manifestation of NMDA receptor encephalitis. The included studies were hampered by difficulties in establishing if these patients had pre-existing NMDA receptor antibodies which entered the brain by infection- or vaccination-associated transient blood-brain barrier leakage. In addition, four cases had comorbid ovarian teratoma, which is a known trigger for development of NMDA receptor encephalitis. Considering that billions of people have contracted COVID-19 or have been vaccinated against this virus, the publication of only 19 case reports with a possible link to NMDA receptor encephalitis, indicates that it is rare. In conclusion, these findings do not support the case that SARS-CoV-2 infection or vaccination led to an increase of existing or de novo encephalitis mediated by an autoimmune response targeting NMDA receptor function. Nevertheless, this work underscores the importance of ongoing vigilance in monitoring viral outbreaks and their potential impact on the central nervous system through basic, epidemiological and translational research.
    MeSH term(s) Humans ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Antibodies ; COVID-19/complications ; Receptors, N-Methyl-D-Aspartate ; SARS-CoV-2
    Chemical Substances Antibodies ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02831-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Possible temporal relationship between SARS-CoV-2 infection and anti-NMDA receptor encephalitis

    Vasilevska, Veronika / Guest, Paul C. / Szardenings, Michael / Benros, Michael E. / Steiner, Johann

    a meta-analysis

    2024  

    Abstract: ... of NMDA receptor encephalitis associated with SARS-CoV-2 infection or vaccination by a systematic ... causal relationship exists between SARS-CoV-2 infection or vaccination and manifestation of NMDA receptor ... The global impact of SARS-CoV-2 infection has raised concerns about secondary diseases beyond acute ...

    Abstract The global impact of SARS-CoV-2 infection has raised concerns about secondary diseases beyond acute illness. This review explores the significance and potential underlying mechanisms of how SARS-CoV-2 infection might elicit an immune response targeting N-methyl-D-aspartate (NMDA) receptors, and its implications for autoimmune-driven neuropsychiatric manifestations. We identified 19 published case reports of NMDA receptor encephalitis associated with SARS-CoV-2 infection or vaccination by a systematic literature search. The significance of these reports was limited since it is not clear if a coincidental or causal relationship exists between SARS-CoV-2 infection or vaccination and manifestation of NMDA receptor encephalitis. The included studies were hampered by difficulties in establishing if these patients had pre-existing NMDA receptor antibodies which entered the brain by infection- or vaccination-associated transient blood-brain barrier leakage. In addition, four cases had comorbid ovarian teratoma, which is a known trigger for development of NMDA receptor encephalitis. Considering that billions of people have contracted COVID-19 or have been vaccinated against this virus, the publication of only 19 case reports with a possible link to NMDA receptor encephalitis, indicates that it is rare. In conclusion, these findings do not support the case that SARS-CoV-2 infection or vaccination led to an increase of existing or de novo encephalitis mediated by an autoimmune response targeting NMDA receptor function. Nevertheless, this work underscores the importance of ongoing vigilance in monitoring viral outbreaks and their potential impact on the central nervous system through basic, epidemiological and translational research.

    14

    1
    Subject code 616
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  4. Article ; Online: Encefalitis anti-NMDA-R secundaria a infección por SARS-CoV-2.

    Álvarez Bravo, G / Ramió I Torrentà, L

    Neurologia (Barcelona, Spain)

    2020  Volume 35, Issue 9, Page(s) 699–700

    Title translation Anti-NMDA receptor encephalitis secondary to SARS-CoV-2 infection.
    Language Spanish
    Publishing date 2020-08-03
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1056021-x
    ISSN 1578-1968 ; 0213-4853
    ISSN (online) 1578-1968
    ISSN 0213-4853
    DOI 10.1016/j.nrl.2020.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Encefalitis anti-NMDA-R secundaria a infección por SARS-CoV-2.

    Álvarez Bravo, G / Ramió I Torrentà, L

    Neurologia (Barcelona, Spain)

    2020  Volume 35, Issue 9, Page(s) 699–700

    Title translation Anti-NMDA receptor encephalitis secondary to SARS-CoV-2 infection.
    MeSH term(s) Adult ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/virology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/physiopathology ; Drug Combinations ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Lopinavir/therapeutic use ; Mental Disorders/virology ; Pandemics ; Ritonavir/therapeutic use ; SARS-CoV-2/drug effects
    Chemical Substances Drug Combinations ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language Spanish
    Publishing date 2020-08-03
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 2654369-2
    ISSN 2173-5808 ; 2173-5808
    ISSN (online) 2173-5808
    ISSN 2173-5808
    DOI 10.1016/j.nrl.2020.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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