Article ; Online: Hyper-reactive malarial splenomegaly (HMS) in a patient with β thalassaemia syndrome.
The Pan African medical journal
2014 Volume 19, Page(s) 310
Abstract: This report describes a case of hyper-reactive malarial splenomegaly in a patient ... and is common in malaria endemic areas. Hyper-reactive malarial splenomegaly is also a common cause ... with a thalassaemia syndrome. Increased haemoglobin A2 is valuable for the diagnosis of common forms of β-thalassemia ...
| Abstract | This report describes a case of hyper-reactive malarial splenomegaly in a patient with a thalassaemia syndrome. Increased haemoglobin A2 is valuable for the diagnosis of common forms of β-thalassemia, while haemoglobin F (HbF) helps in diagnosis of the rarer δβ- forms. Thalassemia is characterised by splenomegaly and is common in malaria endemic areas. Hyper-reactive malarial splenomegaly is also a common cause of massive splenomegaly in malaria endemic areas. Splenic enlargement regresses with prolonged antimalarial therapy. |
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| MeSH term(s) | Adolescent ; Antimalarials/therapeutic use ; Female ; Humans ; Malaria/complications ; Malaria/drug therapy ; Splenomegaly/drug therapy ; Splenomegaly/parasitology ; beta-Thalassemia/physiopathology |
| Chemical Substances | Antimalarials |
| Language | English |
| Publishing date | 2014 |
| Publishing country | Uganda |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2514347-5 |
| ISSN | 1937-8688 ; 1937-8688 |
| ISSN (online) | 1937-8688 |
| ISSN | 1937-8688 |
| DOI | 10.11604/pamj.2014.19.310.5576 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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