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Article ; Online: Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.

Amorim, Inês S / Graham, Laura C / Carter, Roderick N / Morton, Nicholas M / Hammachi, Fella / Kunath, Tilo / Pennetta, Giuseppa / Carpanini, Sarah M / Manson, Jean C / Lamont, Douglas J / Wishart, Thomas M / Gillingwater, Thomas H

Journal of cell science

2017  Volume 130, Issue 2, Page(s) 325–331

Abstract: ... of synapses to degeneration. However, the downstream mechanisms through which α-synuclein controls synaptic ... α-Synuclein plays a central role in Parkinson's disease, where it contributes to the vulnerability ... from α-synuclein ...

Abstract α-Synuclein plays a central role in Parkinson's disease, where it contributes to the vulnerability of synapses to degeneration. However, the downstream mechanisms through which α-synuclein controls synaptic stability and degeneration are not fully understood. Here, comparative proteomics on synapses isolated from α-synuclein
MeSH term(s) Animals ; Cation Transport Proteins/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Energy Metabolism ; Gene Ontology ; Humans ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/metabolism ; Neuromuscular Junction/metabolism ; Synapses/metabolism ; alpha-Synuclein/metabolism
Chemical Substances Cation Transport Proteins ; Drosophila Proteins ; Membrane Proteins ; Mitochondrial Proteins ; Sfxn2 protein, Drosophila ; Sfxn3 protein, mouse ; alpha-Synuclein
Language English
Publishing date 2017-01-03
Publishing country England
Document type Journal Article
ZDB-ID 2993-2
ISSN 1477-9137 ; 0021-9533
ISSN (online) 1477-9137
ISSN 0021-9533
DOI 10.1242/jcs.194241
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