Article ; Online: Prognostic Value of Antithrombin Levels in COVID-19 Patients and Impact of Fresh Frozen Plasma Treatment: A Retrospective Study
Turkish journal of haematology : official journal of Turkish Society of Haematology
2021 Volume 38, Issue 1, Page(s) 15–21
Abstract: ... the prognostic values of antithrombin (AT) activity levels and the impact of fresh frozen plasma (FFP ... used as a prognostic marker for survival and organ failure in COVID-19-associated ARDS patients ... of intravascular coagulation and organ dysfunction in coronavirus disease-19 (COVID-19) patients. Abnormal ...
| Abstract | Objective: The defective interplay between coagulation and inflammation may be the leading cause of intravascular coagulation and organ dysfunction in coronavirus disease-19 (COVID-19) patients. Abnormal coagulation profiles were reported to be associated with poor outcomes. In this study, we assessed the prognostic values of antithrombin (AT) activity levels and the impact of fresh frozen plasma (FFP) treatment on outcome. Materials and methods: Conventional coagulation parameters as well as AT activity levels and outcomes of 104 consecutive critically ill acute respiratory distress syndrome (ARDS) patients with laboratory-confirmed COVID-19 disease were retrospectively analyzed. Patients with AT activity below 75% were treated with FFP. Maximum AT activity levels achieved in those patients were recorded. Results: AT activity levels at admission were significantly lower in nonsurvivors than survivors (73% vs. 81%). The cutoff level for admission AT activity was 79% and 58% was the lowest AT for survival. The outcome in those patients who had AT activity levels above 75% after FFP treatment was better than that of the nonresponding group. As well as AT, admission values of D-dimer, C-reactive protein, and procalcitonin were coagulation and inflammatory parameters among the mortality risk factors. Conclusion: AT activity could be used as a prognostic marker for survival and organ failure in COVID-19-associated ARDS patients. AT supplementation therapy with FFP in patients with COVID-19-induced hypercoagulopathy may improve thrombosis prophylaxis and thus have an impact on survival. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Antithrombins/blood ; Antithrombins/physiology ; Antithrombins/therapeutic use ; Blood Coagulation Tests/methods ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/therapy ; Case-Control Studies ; Critical Illness/mortality ; Disseminated Intravascular Coagulation/etiology ; Disseminated Intravascular Coagulation/prevention & control ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Middle Aged ; Multiple Organ Failure/etiology ; Multiple Organ Failure/prevention & control ; Plasma ; Procalcitonin/analysis ; Prognosis ; Retrospective Studies ; SARS-CoV-2/genetics ; Thrombophilia/complications ; Thrombophilia/physiopathology ; Turkey/epidemiology |
| Chemical Substances | Antithrombins ; Fibrin Fibrinogen Degradation Products ; Procalcitonin ; fibrin fragment D ; C-Reactive Protein (9007-41-4) |
| Language | English |
| Publishing date | 2021-01-25 |
| Publishing country | Turkey |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2185903-6 |
| ISSN | 1308-5263 ; 1300-7777 |
| ISSN (online) | 1308-5263 |
| ISSN | 1300-7777 |
| DOI | 10.4274/tjh.galenos.2021.2020.0695 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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