Article: Serum galectin-1 in patients with multiple myeloma: associations with survival, angiogenesis, and biomarkers of macrophage activation.
2017 Volume 10, Page(s) 1977–1982
Abstract: ... the macrophage activation biomarkers soluble CD163 (sCD163) and soluble mannose receptor. Serum Gal-1 levels were not ... However, serum levels of Gal-1 have never been investigated in patients with multiple myeloma (MM). We measured ... and after treatment (n=24) and examined associations of serum Gal-1 with clinicopathological ...
| Abstract | Galectin-1 (Gal-1) is known to regulate cell signaling within the immune system and may be a target for new anticancer immune therapy. In patients with chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), high levels of Gal-1 within the tumor microenvironment were associated with worse disease state or poor outcome. Gal-1 can be secreted from cells by an unknown mechanism, and levels in blood samples were associated with high tumor burden and worse disease state in cHL and CLL patients. However, serum levels of Gal-1 have never been investigated in patients with multiple myeloma (MM). We measured serum Gal-1 levels in samples from patients with treatment demanding MM at the time of diagnosis (n=102) and after treatment (n=24) and examined associations of serum Gal-1 with clinicopathological information obtained from patient medical records, as well as data on bone marrow angiogenesis and the macrophage activation biomarkers soluble CD163 (sCD163) and soluble mannose receptor. Serum Gal-1 levels were not elevated in patients with MM at diagnosis compared with healthy donors (median values 8.48 vs 11.93 ng/mL, |
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| Language | English |
| Publishing date | 2017-04-04 |
| Publishing country | New Zealand |
| Document type | Journal Article |
| ZDB-ID | 2495130-4 |
| ISSN | 1178-6930 |
| ISSN | 1178-6930 |
| DOI | 10.2147/OTT.S124321 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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