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  1. Article ; Online: Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection.

    Anderson, Michaela R / Ferrante, Anthony W / Baldwin, Matthew R

    Annals of internal medicine

    2021  Volume 174, Issue 6, Page(s) 886

    MeSH term(s) Body Mass Index ; COVID-19 ; Humans ; Intubation, Intratracheal/adverse effects ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection.

    Sanchis-Gomar, Fabian / Lavie, Carl J / Sharma, Abhishek / Henry, Brandon M / Lippi, Giuseppe

    Annals of internal medicine

    2021  Volume 174, Issue 6, Page(s) 885–886

    MeSH term(s) Body Mass Index ; COVID-19 ; Humans ; Intubation, Intratracheal/adverse effects ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection : A Retrospective Cohort Study.

    Anderson, Michaela R / Geleris, Joshua / Anderson, David R / Zucker, Jason / Nobel, Yael R / Freedberg, Daniel / Small-Saunders, Jennifer / Rajagopalan, Kartik N / Greendyk, Richard / Chae, Sae-Rom / Natarajan, Karthik / Roh, David / Edwin, Ethan / Gallagher, Dympna / Podolanczuk, Anna / Barr, R Graham / Ferrante, Anthony W / Baldwin, Matthew R

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) 782–790

    Abstract: ... higher risk for intubation or death, with the highest risk among those with class 3 obesity (hazard ratio ... with increased risk for intubation or death from COVID-19 in adults younger than 65 years, but not in adults aged ... Body mass index (BMI), admission biomarkers of inflammation (C-reactive protein [CRP] level and ...

    Abstract Background: Obesity is a risk factor for pneumonia and acute respiratory distress syndrome.
    Objective: To determine whether obesity is associated with intubation or death, inflammation, cardiac injury, or fibrinolysis in coronavirus disease 2019 (COVID-19).
    Design: Retrospective cohort study.
    Setting: A quaternary academic medical center and community hospital in New York City.
    Participants: 2466 adults hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection over a 45-day period with at least 47 days of in-hospital observation.
    Measurements: Body mass index (BMI), admission biomarkers of inflammation (C-reactive protein [CRP] level and erythrocyte sedimentation rate [ESR]), cardiac injury (troponin level), and fibrinolysis (D-dimer level). The primary end point was a composite of intubation or death in time-to-event analysis.
    Results: Over a median hospital length of stay of 7 days (interquartile range, 3 to 14 days), 533 patients (22%) were intubated, 627 (25%) died, and 59 (2%) remained hospitalized. Compared with overweight patients, patients with obesity had higher risk for intubation or death, with the highest risk among those with class 3 obesity (hazard ratio, 1.6 [95% CI, 1.1 to 2.1]). This association was primarily observed among patients younger than 65 years and not in older patients (
    Limitations: Body mass index was missing for 28% of patients. The primary analyses were conducted with multiple imputation for missing BMI. Upper bounding factor analysis suggested that the results are robust to possible selection bias.
    Conclusion: Obesity is associated with increased risk for intubation or death from COVID-19 in adults younger than 65 years, but not in adults aged 65 years or older.
    Primary funding source: National Institutes of Health.
    MeSH term(s) Academic Medical Centers ; Age Factors ; Aged ; Betacoronavirus ; Biomarkers/blood ; Blood Sedimentation ; Body Mass Index ; C-Reactive Protein/analysis ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Hospitalization ; Hospitals, Community ; Humans ; Intubation, Intratracheal/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; New York City/epidemiology ; Obesity/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Proportional Hazards Models ; Retrospective Studies ; SARS-CoV-2 ; Troponin/blood
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; Troponin ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-3214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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  4. Article ; Online: Impact of body mass index on the outcome of Japanese patients with cardiovascular diseases and/or risk factors hospitalized with COVID-19 infection.

    Saito, Takafumi / Yamaguchi, Tetsuo / Kuroda, Shunsuke / Kitai, Takeshi / Yonetsu, Taishi / Kohsaka, Shun / Torii, Sho / Node, Koichi / Matsumoto, Shingo / Matsue, Yuya / Kodama, Takahide

    Journal of cardiology

    2021  Volume 79, Issue 4, Page(s) 476–481

    Abstract: ... and in-hospital outcomes in 580 Japanese patients with cardiovascular disease and/or risk factors and ... with Cardiovascular Disease and/or Risk Factors (CLAVIS-COVID) registry. BMI was classified into four groups accordance ... In-hospital death occurred in 15.0% (n=87) of the patients and intubation was performed for 139 (24.0 ...

    Abstract Background: Obesity is reported to be a predictor of adverse clinical events in coronavirus disease 2019 (COVID-19) in Western countries. However, there are limited data reported regarding the prognostic impact of obesity in Asian patients. We investigated the relationship between body mass index (BMI) and in-hospital outcomes in 580 Japanese patients with cardiovascular disease and/or risk factors and who were admitted for COVID-19 infection using data from 49 hospitals in Japan.
    Methods: We analyzed data from the Clinical Outcomes of COVID-19 Infection in Hospitalized Patients with Cardiovascular Disease and/or Risk Factors (CLAVIS-COVID) registry. BMI was classified into four groups accordance with the definition of the Japan Society for the Study of Obesity, as follows: underweight, <18.5 kg/m
    Results: In-hospital death occurred in 15.0% (n=87) of the patients and intubation was performed for 139 (24.0%) patients. In a multivariate analysis, we found a significant association between higher BMI and in-hospital mortality [underweight: hazard ratio (HR) 0.47, 95% confidence interval (CI) 0.23-0.97; p=0.041; pre-obese: HR 1.46, 95%CI 0.84-2.55; p=0.18; and obese: HR 3.28, 95%CI 1.34-8.02; p=0.009 vs. normal range]. In contrast, the association between BMI and the intubation rate was not statistically significant.
    Conclusions: Obesity was associated with a stepwise increase in the risk of in-hospital mortality in Japanese patients with COVID-19 infection. The threshold BMI for the increased risk of a worse outcome was 30, which was much lower in comparison to Western countries.
    MeSH term(s) Body Mass Index ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Hospital Mortality ; Humans ; Japan/epidemiology ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-09-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2021.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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