Article ; Online: Role of matrix metalloproteinases and their inhibitor in the development of early pulmonary fibrosis in mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus.
Bulletin of experimental biology and medicine
2013 Volume 156, Issue 1, Page(s) 11–14
Abstract: ... Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance ... I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose ... the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type ...
| Abstract | High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2. |
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| MeSH term(s) | Animals ; Collagen/metabolism ; Fibroblasts/enzymology ; Influenza A Virus, H5N1 Subtype ; Macrophages, Alveolar/enzymology ; Male ; Matrix Metalloproteinases, Secreted/metabolism ; Mice ; Mice, Inbred C57BL ; Pulmonary Fibrosis/enzymology ; Pulmonary Fibrosis/virology ; Respiratory Tract Infections/enzymology ; Respiratory Tract Infections/virology ; Tissue Inhibitor of Metalloproteinase-2/metabolism | |||||
| Chemical Substances | Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Collagen (9007-34-5) ; Matrix Metalloproteinases, Secreted (EC 3.4.24.-) | |||||
| Language | English | |||||
| Publishing date | 2013-06-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 390407-6 | |||||
| ISSN | 1573-8221 ; 0007-4888 ; 0365-9615 | |||||
| ISSN (online) | 1573-8221 | |||||
| ISSN | 0007-4888 ; 0365-9615 | |||||
| DOI | 10.1007/s10517-013-2265-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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